format-version: 1.2
data-version: go/releases/2024-03-08/imports/cl_import.owl
ontology: go/imports/cl_import
[Term]
id: CL:0000000
name: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." []
is_a: UBERON:0000061
relationship: RO:0002160 NCBITaxon:131567
[Term]
id: CL:0000005
name: fibroblast neural crest derived
def: "Any fibroblast that is deriived from the neural crest." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell
relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell
[Term]
id: CL:0000006
name: neuronal receptor cell
synonym: "neuronal receptor cell (sensu Animalia)" EXACT []
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050906
[Term]
id: CL:0000007
name: early embryonic cell (metazoa)
def: "A cell found in the embryo before the formation of all the gem layers is complete." []
is_a: CL:0002321 ! embryonic cell (metazoa)
[Term]
id: CL:0000008
name: migratory cranial neural crest cell
def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." []
is_a: CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000011
name: migratory trunk neural crest cell
def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." []
is_a: CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000014
name: germ line stem cell
def: "A stem cell that is the precursor of gametes." []
synonym: "germline stem cell" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:0000039 ! germ line cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: RO:0002215 GO:0017145
[Term]
id: CL:0000015
name: male germ cell
def: "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." []
is_a: CL:0000586 ! germ cell
relationship: RO:0002216 GO:0007283
[Term]
id: CL:0000016
name: male germ line stem cell
def: "A stem cell that is the precursor of male gametes." []
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000015 ! male germ cell
[Term]
id: CL:0000017
name: spermatocyte
def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." []
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: RO:0002215 GO:0048137
relationship: RO:0002202 CL:0000020 ! spermatogonium
[Term]
id: CL:0000018
name: spermatid
def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." []
synonym: "nematoblast" EXACT []
is_a: CL:0000015 ! male germ cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: RO:0000053 PATO:0001375
intersection_of: RO:0002215 GO:0001675
intersection_of: RO:0002215 GO:0007288
intersection_of: RO:0002215 GO:0007289
relationship: RO:0002202 CL:0000657 ! secondary spermatocyte
[Term]
id: CL:0000019
name: sperm
def: "A mature male germ cell that develops from a spermatid." []
synonym: "sperm cell" EXACT []
synonym: "spermatozoid" EXACT []
synonym: "spermatozoon" EXACT []
is_a: CL:0000408 ! male gamete
relationship: RO:0002202 CL:0000018 ! spermatid
[Term]
id: CL:0000020
name: spermatogonium
def: "An euploid male germ cell of an early stage of spermatogenesis." []
synonym: "spermatogonial cell" EXACT []
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: RO:0000053 PATO:0001394
intersection_of: RO:0000053 PATO:0001501
[Term]
id: CL:0000021
name: female germ cell
def: "Female germ cell is a germ cell that supports female gamete production." []
is_a: CL:0000586 ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: RO:0002215 GO:0048477
[Term]
id: CL:0000022
name: female germ line stem cell
def: "A stem cell that is the precursor of female gametes." []
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000021 ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: RO:0002215 GO:0017145
[Term]
id: CL:0000023
name: oocyte
def: "A female germ cell that has entered meiosis." []
synonym: "oogonium" RELATED []
is_a: CL:0000021 ! female germ cell
relationship: RO:0000056 GO:0007143
relationship: RO:0002160 NCBITaxon:33208
[Term]
id: CL:0000024
name: oogonial cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." []
is_a: CL:0000021 ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: RO:0002215 GO:0000278
relationship: RO:0002202 CL:0000670 ! primordial germ cell
[Term]
id: CL:0000025
name: egg cell
def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." []
synonym: "mature oocyte" EXACT []
synonym: "ovum" EXACT []
is_a: CL:0000675 ! female gamete
relationship: RO:0000056 GO:0007143
relationship: RO:0002202 CL:0000023 ! oocyte
[Term]
id: CL:0000026
name: invertebrate nurse cell
def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." []
synonym: "nurse cell" RELATED []
is_a: CL:0000412 ! polyploid cell
is_a: CL:4029002 ! germline-derived nurse cell
relationship: RO:0002202 CL:0000722 ! cystoblast
[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
def: "A smooth muscle cell derived from the neural crest." []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell
relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell
[Term]
id: CL:0000029
name: neural crest derived neuron
synonym: "neuron neural crest derived" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell
relationship: RO:0002202 CL:0002676 ! neural crest derived neuroblast
[Term]
id: CL:0000030
name: glioblast
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: RO:0002202 CL:0000133 ! neurectodermal cell
[Term]
id: CL:0000031
name: neuroblast (sensu Vertebrata)
def: "A cell that will develop into a neuron often after a migration phase." []
synonym: "neuroblast" EXACT []
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: RO:0002160 NCBITaxon:7742
[Term]
id: CL:0000034
name: stem cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." []
synonym: "animal stem cell" EXACT []
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0017145
relationship: RO:0002162 NCBITaxon:33208
relationship: RO:0002215 GO:0030154
[Term]
id: CL:0000035
name: single fate stem cell
def: "A stem cell that self-renews as well as give rise to a single mature cell type." []
synonym: "unipotent stem cell" EXACT []
synonym: "unipotential stem cell" EXACT []
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001400
intersection_of: RO:0002215 GO:0017145
[Term]
id: CL:0000036
name: epithelial fate stem cell
synonym: "epithelial stem cell" EXACT []
is_a: CL:0000035 ! single fate stem cell
[Term]
id: CL:0000037
name: hematopoietic stem cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." []
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
synonym: "HSC" RELATED []
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002215 GO:0002244
intersection_of: RO:0002215 GO:0048103
relationship: RO:0002202 CL:0000566 ! angioblastic mesenchymal cell
[Term]
id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." []
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell
[Term]
id: CL:0000039
name: germ line cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." []
is_a: CL:0000000 ! cell
relationship: RO:0002215 GO:0022414
[Term]
id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." []
synonym: "CFU-M" RELATED []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
is_a: CL:0002194 ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000791
intersection_of: BFO:0000051 GO:0005730
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002215 GO:0030224
relationship: RO:0002202 CL:0002009 ! macrophage dendritic cell progenitor
[Term]
id: CL:0000042
name: neutrophilic myeloblast
def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." []
synonym: "neutrophilic granuloblast" RELATED []
is_a: CL:0000834 ! neutrophil progenitor cell
is_a: CL:0000835 ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: BFO:0000051 PR:000001944
intersection_of: BFO:0000051 PR:000005307
intersection_of: BFO:0000051 PR:000007857
intersection_of: BFO:0000051 PR:000010799
intersection_of: BFO:0000051 PR:000014362
intersection_of: RO:0002215 GO:0030223
relationship: RO:0002202 CL:0000834 ! neutrophil progenitor cell
[Term]
id: CL:0000043
name: mature basophil
def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." []
synonym: "mature basophil leucocyte" EXACT []
synonym: "mature basophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000767 ! basophil
is_a: CL:0002274 ! histamine secreting cell
relationship: RO:0002202 CL:0000770 ! band form basophil
[Term]
id: CL:0000047
name: neural stem cell
def: "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." []
synonym: "neuronal stem cell" EXACT []
synonym: "NSC" EXACT []
is_a: CL:0002319 ! neural cell
relationship: RO:0002202 CL:0000133 ! neurectodermal cell
[Term]
id: CL:0000048
name: multi fate stem cell
def: "A stem cell that can give rise to multiple lineages of cells." []
synonym: "multi-fate stem cell" EXACT []
synonym: "multifate stem cell" EXACT []
synonym: "multipotent cell" EXACT []
synonym: "multipotent stem cell" EXACT []
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001402
intersection_of: RO:0002215 GO:0017145
[Term]
id: CL:0000049
name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." []
synonym: "CFU-GEMM" RELATED []
synonym: "CFU-S" RELATED []
synonym: "CMP" RELATED []
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED []
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED []
synonym: "myeloid stem cell" RELATED []
synonym: "pluripotent stem cell (bone marrow)" RELATED []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell
disjoint_from: CL:0000051 ! common lymphoid progenitor
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell
[Term]
id: CL:0000050
name: megakaryocyte-erythroid progenitor cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." []
synonym: "CFU-EM" EXACT []
synonym: "CFU-MegE" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "Meg/E progenitor" EXACT []
synonym: "megakaryocyte/erythrocyte progenitor" EXACT []
synonym: "megakaryocyte/erythroid progenitor cell" EXACT []
synonym: "MEP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: RO:0002215 GO:0030218
intersection_of: RO:0002215 GO:0030219
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell
disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor
relationship: RO:0002202 CL:0000049 ! common myeloid progenitor
[Term]
id: CL:0000051
name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." []
synonym: "CLP" RELATED []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "ELP" RELATED []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: RO:0002215 GO:0030098
[Term]
id: CL:0000055
name: non-terminally differentiated cell
def: "A precursor cell with a limited number of potential fates." []
synonym: "blast cell" EXACT []
is_a: CL:0011115 ! precursor cell
relationship: RO:0002215 GO:0030154
[Term]
id: CL:0000056
name: myoblast
def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." []
is_a: CL:0000680 ! muscle precursor cell
[Term]
id: CL:0000057
name: fibroblast
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." []
is_a: CL:0002320 ! connective tissue cell
relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000058
name: chondroblast
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." []
synonym: "chrondoplast" EXACT []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: RO:0002202 CL:0007009 ! prechondroblast
relationship: RO:0003000 UBERON:0002418
[Term]
id: CL:0000059
name: ameloblast
def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." []
synonym: "amelocyte" EXACT []
synonym: "enamel secreting cell" EXACT []
is_a: CL:0000146 ! simple columnar epithelial cell
is_a: CL:0000151 ! secretory cell
relationship: BFO:0000050 UBERON:0005176
relationship: RO:0002202 CL:0007000 ! preameloblast
relationship: RO:0002215 GO:0097186
relationship: RO:0002220 UBERON:0001763
relationship: RO:0003000 UBERON:0001752
[Term]
id: CL:0000060
name: odontoblast
def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002148 ! dental pulp cell
relationship: BFO:0000050 UBERON:0005176
relationship: RO:0002202 CL:0007003 ! preodontoblast
relationship: RO:0003000 UBERON:0001751
[Term]
id: CL:0000062
name: osteoblast
def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: RO:0002202 CL:0007010 ! preosteoblast
relationship: RO:0003000 UBERON:0008883
[Term]
id: CL:0000064
name: ciliated cell
def: "A cell that has a filiform extrusion of the cell surface." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000051 GO:0005929
[Term]
id: CL:0000066
name: epithelial cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." []
synonym: "epitheliocyte" EXACT []
is_a: CL:0000000 ! cell
disjoint_from: CL:0000738 ! leukocyte
relationship: BFO:0000050 UBERON:0000483
[Term]
id: CL:0000067
name: ciliated epithelial cell
def: "An epithelial cell that has a cilia." []
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000051 GO:0005929
[Term]
id: CL:0000068
name: duct epithelial cell
def: "An epithelial cell that is part of a duct." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000058
[Term]
id: CL:0000069
name: branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell
[Term]
id: CL:0000071
name: blood vessel endothelial cell
def: "An endothelial cell that lines the vasculature." []
synonym: "cuboidal endothelial cell of vascular tree" EXACT []
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: BFO:0000050 UBERON:0004638
relationship: RO:0002202 CL:0002546 ! embryonic blood vessel endothelial progenitor cell
[Term]
id: CL:0000072
name: non-branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: RO:0002202 CL:0000222 ! mesodermal cell
[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." []
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000076
name: squamous epithelial cell
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000077
name: mesothelial cell
def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." []
synonym: "mesotheliocyte" EXACT []
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: RO:0002202 CL:0000222 ! mesodermal cell
[Term]
id: CL:0000079
name: stratified epithelial cell
is_a: CL:0000066 ! epithelial cell
relationship: RO:0002202 CL:0000357 ! stratified epithelial stem cell
[Term]
id: CL:0000081
name: blood cell
def: "A cell found predominately in the blood." []
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0002215 GO:0008015
[Term]
id: CL:0000082
name: epithelial cell of lung
def: "An epithelial cell of the lung." []
synonym: "lung epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002048
relationship: BFO:0000050 UBERON:0000115
[Term]
id: CL:0000083
name: epithelial cell of pancreas
def: "An epithelial cell of the pancreas." []
synonym: "pancreas epithelial cell" EXACT []
synonym: "pancreatic epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001264
relationship: RO:0002202 CL:0000223 ! endodermal cell
[Term]
id: CL:0000084
name: T cell
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." []
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: RO:0002215 GO:0002456
disjoint_from: CL:0000945 ! lymphocyte of B lineage
relationship: RO:0002202 CL:0000827 ! pro-T cell
[Term]
id: CL:0000092
name: osteoclast
def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." []
synonym: "chondroclast" RELATED []
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000050 UBERON:0001474
intersection_of: BFO:0000051 PR:000001850
intersection_of: BFO:0000051 PR:000001937
intersection_of: BFO:0000051 PR:000001944
intersection_of: BFO:0000051 PR:000007597
intersection_of: BFO:0000051 PR:000011178
intersection_of: RO:0002104 PR:000001954
intersection_of: RO:0002104 PR:000002062
intersection_of: RO:0002215 GO:0045453
relationship: RO:0002202 CL:0000576 ! monocyte
[Term]
id: CL:0000094
name: granulocyte
def: "A leukocyte with abundant granules in the cytoplasm." []
synonym: "granular leucocyte" EXACT []
synonym: "granular leukocyte" EXACT []
synonym: "polymorphonuclear leukocyte" EXACT []
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000051 GO:0030141
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001332
intersection_of: RO:0002104 PR:000001969
intersection_of: RO:0002215 GO:0008015
[Term]
id: CL:0000095
name: neuron associated cell
is_a: CL:0002319 ! neural cell
relationship: RO:0002202 CL:0000133 ! neurectodermal cell
[Term]
id: CL:0000096
name: mature neutrophil
def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." []
synonym: "mature neutrocyte" EXACT []
synonym: "mature neutrophil leucocyte" EXACT []
synonym: "mature neutrophil leukocyte" EXACT []
synonym: "mature neutrophilic leucocyte" EXACT []
synonym: "mature neutrophilic leukocyte" EXACT []
synonym: "PMN" EXACT []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" EXACT []
synonym: "polynuclear neutrophilic leucocyte" EXACT []
synonym: "polynuclear neutrophilic leukocyte" EXACT []
is_a: CL:0000234 ! phagocyte
is_a: CL:0000775 ! neutrophil
[Term]
id: CL:0000097
name: mast cell
def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." []
synonym: "histaminocyte" EXACT []
synonym: "labrocyte" EXACT []
synonym: "mastocyte" EXACT []
synonym: "tissue basophil" RELATED []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0002274 ! histamine secreting cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000051 GO:0030141
intersection_of: lacks_plasma_membrane_part PR:000001865
intersection_of: RO:0002104 PR:000001255
intersection_of: RO:0002104 PR:000006169
intersection_of: RO:0002215 GO:0002349
intersection_of: RO:0002215 GO:0002539
intersection_of: RO:0002215 GO:0002660
intersection_of: RO:0002215 GO:0002690
intersection_of: RO:0002215 GO:0002830
intersection_of: RO:0002215 GO:0030210
intersection_of: RO:0015015 PR:000002065
intersection_of: RO:0015015 PR:000007431
relationship: RO:0002202 CL:0000831 ! mast cell progenitor
[Term]
id: CL:0000098
name: sensory epithelial cell
def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." []
synonym: "neuroepithelial cell" BROAD []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002215 GO:0050906
[Term]
id: CL:0000099
name: interneuron
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." []
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000100
name: motor neuron
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." []
synonym: "motoneuron" EXACT []
is_a: CL:0000527 ! efferent neuron
[Term]
id: CL:0000101
name: sensory neuron
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." []
is_a: CL:0000526 ! afferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050906
[Term]
id: CL:0000103
name: bipolar neuron
def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." []
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0000053 PATO:0070006
[Term]
id: CL:0000106
name: unipolar neuron
def: "Neuron with one neurite that extends from the cell body." []
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000107
name: autonomic neuron
def: "A neuron whose cell body is within an autonomic ganglion." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002410
[Term]
id: CL:0000108
name: cholinergic neuron
def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0014055
[Term]
id: CL:0000113
name: mononuclear phagocyte
def: "A vertebrate phagocyte with a single nucleus." []
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000842 ! mononuclear cell
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: RO:0000053 PATO:0001407
[Term]
id: CL:0000114
name: surface ectodermal cell
synonym: "cell of surface ectoderm" EXACT []
synonym: "surface ectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell
[Term]
id: CL:0000115
name: endothelial cell
def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." []
synonym: "endotheliocyte" EXACT []
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0000117
name: CNS neuron (sensu Vertebrata)
is_a: CL:0000540 ! neuron
relationship: BFO:0000050 UBERON:0001017
relationship: RO:0002202 CL:0000031 ! neuroblast (sensu Vertebrata)
[Term]
id: CL:0000119
name: cerebellar Golgi cell
def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." []
synonym: "cerebellar Golgi neuron" EXACT []
synonym: "cerebellum Golgi cell" EXACT []
synonym: "Golgi cell" EXACT []
synonym: "Golgi neuron" EXACT []
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
relationship: RO:0002100 UBERON:0002129
[Term]
id: CL:0000120
name: granule cell
def: "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
[Term]
id: CL:0000121
name: Purkinje cell
def: "The output neuron of the cerebellar cortex." []
synonym: "cerebellar Purkinje cell" EXACT []
synonym: "cerebellum Purkinje cell" EXACT []
synonym: "Purkinje neuron" EXACT []
synonym: "Purkinje's cell" EXACT []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
is_a: CL:0000527 ! efferent neuron
relationship: RO:0002100 UBERON:0002129
[Term]
id: CL:0000122
name: stellate neuron
def: "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: RO:0000053 PATO:0070010
[Term]
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
is_a: CL:0000095 ! neuron associated cell
relationship: RO:0002160 NCBITaxon:7742
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000125
name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." []
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
is_a: CL:0000095 ! neuron associated cell
[Term]
id: CL:0000126
name: macroglial cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." []
synonym: "macroglia" RELATED []
synonym: "macrogliocyte" EXACT []
is_a: CL:0000125 ! glial cell
relationship: RO:0002202 CL:0000339 ! glioblast (sensu Vertebrata)
[Term]
id: CL:0000127
name: astrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." []
synonym: "astrocytic glia" EXACT []
is_a: CL:0000126 ! macroglial cell
[Term]
id: CL:0000128
name: oligodendrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." []
synonym: "oligodendroglia" RELATED []
synonym: "OLs" EXACT []
is_a: CL:0000126 ! macroglial cell
is_a: CL:4023154 ! myelinating glial cell
relationship: BFO:0000050 UBERON:0001017
relationship: BFO:0000051 GO:0043209
relationship: RO:0002202 CL:0002453 ! oligodendrocyte precursor cell
[Term]
id: CL:0000129
name: microglial cell
def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." []
synonym: "brain macrophage" BROAD []
synonym: "brain-resident macrophage" EXACT []
synonym: "hortega cells" EXACT []
synonym: "MF.microglia.CNS" RELATED []
synonym: "microglia" RELATED []
synonym: "microgliocyte" EXACT []
is_a: CL:0000125 ! glial cell
is_a: CL:0000878 ! central nervous system macrophage
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0001017
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001813
intersection_of: RO:0002104 PR:000002064
intersection_of: RO:0002215 GO:0045087
relationship: RO:0002202 CL:0000222 ! mesodermal cell
[Term]
id: CL:0000133
name: neurectodermal cell
def: "Ectoderm destined to be nervous tissue." []
synonym: "neurectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell
[Term]
id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." []
synonym: "BMSC" RELATED []
synonym: "bone marrow stromal cells" NARROW []
synonym: "CFU-F" RELATED []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW []
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal progenitor cells" RELATED []
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED []
synonym: "MSC" RELATED []
synonym: "stem cells, mesenchymal" RELATED []
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000135
name: fibrocyte
def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." []
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: RO:0002215 GO:0002495
intersection_of: RO:0002215 GO:0045766
relationship: RO:0002202 CL:0000057 ! fibroblast
[Term]
id: CL:0000136
name: adipocyte
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." []
synonym: "adipose cell" EXACT []
synonym: "fat cell" EXACT []
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000138
name: chondrocyte
def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." []
synonym: "cartilage cell" EXACT []
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000667 ! collagen secreting cell
relationship: RO:0001025 UBERON:0002418
relationship: RO:0002202 CL:0000058 ! chondroblast
[Term]
id: CL:0000145
name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." []
synonym: "APC" RELATED []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: RO:0002215 GO:0002504
[Term]
id: CL:0000146
name: simple columnar epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
[Term]
id: CL:0000147
name: pigment cell
def: "A pigment cell is a cell that contains pigment granules." []
synonym: "chromatocyte" EXACT []
synonym: "chromatophore" EXACT []
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000148
name: melanocyte
def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." []
synonym: "melanophore" NARROW []
is_a: CL:0000147 ! pigment cell
intersection_of: CL:0000147 ! pigment cell
intersection_of: BFO:0000051 GO:0042470
intersection_of: RO:0002202 CL:0000541 ! melanoblast
[Term]
id: CL:0000149
name: visual pigment cell
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000150
name: glandular epithelial cell
def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000151 ! secretory cell
relationship: BFO:0000050 UBERON:0006799
[Term]
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0032940
[Term]
id: CL:0000153
name: glycosaminoglycan secreting cell
def: "A cell that secretes glycosaminoglycans." []
synonym: "GAG secreting cell" EXACT []
synonym: "hyaluronic acid secreting cell" NARROW []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000447 ! carbohydrate secreting cell
[Term]
id: CL:0000154
name: protein secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0009306
[Term]
id: CL:0000157
name: surfactant secreting cell
def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0043129
[Term]
id: CL:0000158
name: club cell
def: "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." []
synonym: "Clara cell" EXACT []
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002104 GO:0005902
relationship: RO:0002215 GO:0032940
relationship: RO:0002215 GO:0043129
[Term]
id: CL:0000159
name: seromucus secreting cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000160
name: goblet cell
def: "A cell of the epithelial lining that produce and secrete mucins." []
synonym: "chalice cell" EXACT []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000319 ! mucus secreting cell
relationship: RO:0002215 GO:0070254
[Term]
id: CL:0000163
name: endocrine cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." []
synonym: "endocrinocyte" EXACT []
is_a: CL:0000000 ! cell
is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="BFO:0000050"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="BFO:0000050"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0000945", gci_relation="BFO:0000050"} ! enteroendocrine cell
relationship: BFO:0000050 UBERON:0000949
[Term]
id: CL:0000164
name: enteroendocrine cell
def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000163 ! endocrine cell
[Term]
id: CL:0000165
name: neuroendocrine cell
def: "A neuron that is capable of some hormone secretion in response to neuronal signals." []
synonym: "neurosecretory cell" RELATED []
synonym: "neurosecretory neuron" RELATED []
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000527 ! efferent neuron
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0046879
[Term]
id: CL:0000166
name: chromaffin cell
def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." []
synonym: "phaeochromocyte" EXACT []
is_a: CL:0000029 ! neural crest derived neuron
is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000167
name: peptide hormone secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0030072
[Term]
id: CL:0000168
name: insulin secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0030073
[Term]
id: CL:0000169
name: type B pancreatic cell
def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." []
synonym: "B-cell of pancreatic islet" EXACT []
synonym: "beta cell" BROAD []
synonym: "beta cell islet" RELATED []
synonym: "beta cell of pancreatic islet" EXACT []
synonym: "insulin-secreting cell" EXACT []
synonym: "pancreatic B cell" EXACT []
synonym: "pancreatic B-cell" EXACT []
synonym: "pancreatic beta cell" EXACT []
synonym: "pancreatic islet core" EXACT []
synonym: "type B enteroendocrine cell" EXACT []
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000168 ! insulin secreting cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0000006
intersection_of: RO:0002215 GO:0030073
relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas
[Term]
id: CL:0000170
name: glucagon secreting cell
def: "A cell that secretes glucagon." []
synonym: "glucagon-secreting cell" EXACT []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0070091
[Term]
id: CL:0000171
name: pancreatic A cell
def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." []
synonym: "alpha cell of islet of Langerhans" EXACT []
synonym: "pancreatic alpha cell" EXACT []
is_a: CL:0002067 ! type A enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0002067 ! type A enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0001264
relationship: BFO:0000050 UBERON:0000006
relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas
relationship: RO:0002215 GO:0070091
[Term]
id: CL:0000172
name: somatostatin secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0070253
[Term]
id: CL:0000173
name: pancreatic D cell
def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." []
synonym: "D-cell of pancreatic islet" EXACT []
synonym: "delta cell of islet" EXACT []
synonym: "delta cell of pancreatic islet" EXACT []
synonym: "pancreatic D-cell" EXACT []
synonym: "pancreatic delta cell" EXACT []
synonym: "somatostatin-secreting pancreatic cell" EXACT []
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0001264
relationship: BFO:0000050 UBERON:0000006
relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas
[Term]
id: CL:0000174
name: steroid hormone secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035929
[Term]
id: CL:0000175
name: luteal cell
def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." []
synonym: "corpus luteum cell" EXACT []
synonym: "lutein cell" EXACT []
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0000179 ! progesterone secreting cell
is_a: CL:0002132 ! stromal cell of ovary
relationship: BFO:0000050 UBERON:0002512
relationship: RO:0002215 GO:0042701
[Term]
id: CL:0000176
name: ecdysteroid secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0045457
[Term]
id: CL:0000177
name: testosterone secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035936
[Term]
id: CL:0000178
name: Leydig cell
def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." []
synonym: "interstitial cell" BROAD []
synonym: "interstitial cell of Leydig" EXACT []
is_a: CL:0000177 ! testosterone secreting cell
relationship: BFO:0000050 UBERON:0005212
relationship: RO:0002202 CL:0009091 ! Leydig stem cell
[Term]
id: CL:0000179
name: progesterone secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0042701
[Term]
id: CL:0000180
name: estradiol secreting cell
def: "A steroid hormone secreting cell that secretes estradiol." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035938
[Term]
id: CL:0000182
name: hepatocyte
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000417 ! endopolyploid cell
relationship: BFO:0000050 UBERON:0002107
relationship: RO:0002202 CL:0005026 ! hepatoblast
relationship: RO:0002215 GO:0006699
relationship: RO:0002215 GO:0044237
relationship: RO:0002215 GO:0098754
[Term]
id: CL:0000183
name: contractile cell
def: "A cell whose primary function is to shorten." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000186
name: myofibroblast cell
def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." []
synonym: "MFB" EXACT []
is_a: CL:0000183 ! contractile cell
is_a: CL:0002320 ! connective tissue cell
relationship: BFO:0000050 UBERON:0002384
[Term]
id: CL:0000187
name: muscle cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." []
synonym: "muscle fiber" EXACT []
synonym: "myocyte" EXACT []
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: RO:0002202 CL:0000056 ! myoblast
[Term]
id: CL:0000188
name: cell of skeletal muscle
def: "A somatic cell located in skeletal muscle." []
synonym: "skeletal muscle cell" EXACT []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001134
[Term]
id: CL:0000189
name: slow muscle cell
def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." []
synonym: "slow muscle fiber" RELATED []
is_a: CL:0008046 ! extrafusal muscle fiber
relationship: RO:0002202 CL:0000857 ! slow muscle myoblast
[Term]
id: CL:0000192
name: smooth muscle cell
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." []
synonym: "myocytes, smooth muscle" EXACT []
synonym: "non-striated muscle cell" BROAD []
synonym: "SMCs" EXACT []
synonym: "smooth muscle fiber" EXACT []
is_a: CL:0008000 ! non-striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
relationship: RO:0002202 CL:0000514 ! smooth muscle myoblast
[Term]
id: CL:0000197
name: sensory receptor cell
def: "A cell that is capable of detection of a stimulus involved in sensory perception." []
synonym: "receptor cell" EXACT []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001032
intersection_of: RO:0002215 GO:0050906
[Term]
id: CL:0000199
name: mechanoreceptor cell
def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." []
synonym: "mechanoreceptor" RELATED []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050974
[Term]
id: CL:0000200
name: touch receptor cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050976
[Term]
id: CL:0000202
name: auditory hair cell
def: "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." []
synonym: "auditory receptor cell" RELATED []
is_a: CL:0000855 ! sensory hair cell
relationship: RO:0002215 GO:0050910
[Term]
id: CL:0000203
name: gravity sensitive cell
is_a: CL:0000006 ! neuronal receptor cell
intersection_of: CL:0000006 ! neuronal receptor cell
intersection_of: RO:0002215 GO:0070999
[Term]
id: CL:0000205
name: thermoreceptor cell
def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." []
is_a: CL:0000006 ! neuronal receptor cell
intersection_of: CL:0000006 ! neuronal receptor cell
intersection_of: RO:0002215 GO:0050960
[Term]
id: CL:0000206
name: chemoreceptor cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." []
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: RO:0002215 GO:0050907
[Term]
id: CL:0000207
name: olfactory receptor cell
synonym: "odorant receptor cell" EXACT []
synonym: "olfactory receptor neuron" EXACT []
synonym: "olfactory sensory neuron" EXACT []
synonym: "Schultze's cell" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050911
relationship: BFO:0000050 UBERON:0005725
[Term]
id: CL:0000209
name: taste receptor cell
def: "A specialized cell involved in gustatory sensory perception." []
synonym: "taste bud cell" EXACT []
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000206 ! chemoreceptor cell
intersection_of: RO:0002215 GO:0050912
[Term]
id: CL:0000210
name: photoreceptor cell
def: "A cell specialized to detect and transduce light." []
is_a: CL:0000006 ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050962
[Term]
id: CL:0000211
name: electrically active cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000213
name: lining cell
def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." []
synonym: "boundary cell" EXACT []
is_a: CL:0000215 ! barrier cell
[Term]
id: CL:0000214
name: synovial cell
def: "A cell located in the synovial joint." []
synonym: "synoviocyte" EXACT []
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: BFO:0000050 UBERON:0002217
[Term]
id: CL:0000215
name: barrier cell
def: "A cell whose primary function is to prevent the transport of stuff across compartments." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000216
name: Sertoli cell
def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." []
is_a: CL:0000511 ! androgen binding protein secreting cell
is_a: CL:0000630 ! supporting cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
intersection_of: CL:0000630 ! supporting cell
intersection_of: BFO:0000050 UBERON:0001343
[Term]
id: CL:0000217
name: insulating cell
is_a: CL:0000215 ! barrier cell
[Term]
id: CL:0000218
name: myelinating Schwann cell
def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." []
synonym: "neurilemmal cell" EXACT []
synonym: "peripheral neuroglial cell" BROAD []
synonym: "Schwann cell" BROAD []
is_a: CL:0000217 ! insulating cell
is_a: CL:0002573 ! Schwann cell
is_a: CL:4023154 ! myelinating glial cell
relationship: BFO:0000051 GO:0043209
relationship: RO:0002202 CL:0002377 ! immature Schwann cell
[Term]
id: CL:0000219
name: motile cell
def: "A cell that moves by its own activities." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0048870
[Term]
id: CL:0000221
name: ectodermal cell
def: "A cell of the outer of the three germ layers of the embryo." []
synonym: "ectoderm cell" EXACT []
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000924
[Term]
id: CL:0000222
name: mesodermal cell
def: "A cell of the middle germ layer of the embryo." []
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000926
[Term]
id: CL:0000223
name: endodermal cell
def: "A cell of the inner of the three germ layers of the embryo." []
synonym: "endoderm cell" EXACT []
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000925
[Term]
id: CL:0000225
name: anucleate cell
def: "A cell that lacks a nucleus." []
synonym: "non-nucleated cell" EXACT []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001405
disjoint_from: CL:0002242 ! nucleate cell
[Term]
id: CL:0000226
name: single nucleate cell
def: "A cell with a single nucleus." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001407
[Term]
id: CL:0000227
name: binucleate cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001406
[Term]
id: CL:0000228
name: multinucleate cell
def: "A cell with more than one nucleus." []
synonym: "syncitium" EXACT []
synonym: "syncytial cell" EXACT []
synonym: "syncytium" EXACT []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001908
[Term]
id: CL:0000232
name: erythrocyte
def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." []
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: lacks_part GO:0005840
intersection_of: lacks_plasma_membrane_part PR:000001945
intersection_of: RO:0000053 PATO:0002039
intersection_of: RO:0002215 GO:0008015
intersection_of: RO:0002215 GO:0015671
relationship: RO:0002202 CL:0000558 ! reticulocyte
[Term]
id: CL:0000233
name: platelet
def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." []
synonym: "anucleate thrombocyte" EXACT []
synonym: "blood platelet" EXACT []
synonym: "enucleate thrombocyte" EXACT []
is_a: CL:0000081 ! blood cell
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000763 ! myeloid cell
relationship: RO:0000053 PATO:0001405
relationship: RO:0000053 PATO:0001874
relationship: RO:0002202 CL:0000556 ! megakaryocyte
relationship: RO:0002215 GO:0001820
relationship: RO:0002216 GO:0007596
[Term]
id: CL:0000234
name: phagocyte
def: "Any cell capable of ingesting particulate matter via phagocytosis." []
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000473 ! defensive cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0006909
[Term]
id: CL:0000235
name: macrophage
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." []
synonym: "histiocyte" EXACT []
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: RO:0002215 GO:0002504
intersection_of: RO:0002215 GO:0006909
intersection_of: RO:0002215 GO:0031268
relationship: RO:0002202 CL:0000576 ! monocyte
[Term]
id: CL:0000236
name: B cell
def: "A lymphocyte of B lineage that is capable of B cell mediated immunity." []
synonym: "B lymphocyte" EXACT []
synonym: "B-cell" EXACT []
synonym: "B-lymphocyte" EXACT []
is_a: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: RO:0002215 GO:0019724
relationship: RO:0002202 CL:0000826 ! pro-B cell
[Term]
id: CL:0000237
name: keratinizing barrier epithelial cell
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:0000311 ! keratin accumulating cell
is_a: CL:0002077 ! ecto-epithelial cell
relationship: RO:0002202 CL:0000114 ! surface ectodermal cell
[Term]
id: CL:0000239
name: brush border epithelial cell
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: BFO:0000051 GO:0005929
[Term]
id: CL:0000240
name: stratified squamous epithelial cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000079 ! stratified epithelial cell
[Term]
id: CL:0000244
name: transitional epithelial cell
def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." []
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000247
name: Rohon-Beard neuron
def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." []
synonym: "RB neuron" RELATED []
synonym: "Rohon Beard cell" EXACT []
synonym: "Rohon-Beard cell" EXACT []
is_a: CL:0000531 ! primary sensory neuron (sensu Teleostei)
is_a: CL:4023168 ! somatosensory neuron
[Term]
id: CL:0000253
name: eurydendroid cell
is_a: CL:0000527 ! efferent neuron
[Term]
id: CL:0000255
name: eukaryotic cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002160 NCBITaxon:2759
disjoint_from: CL:0000520 ! prokaryotic cell
[Term]
id: CL:0000287
name: eye photoreceptor cell
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: BFO:0000050 UBERON:0000970
[Term]
id: CL:0000295
name: somatotropin secreting cell
def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." []
synonym: "growth hormone secreting cell" EXACT []
synonym: "somatotrophin secreting cell" EXACT []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0030252
[Term]
id: CL:0000300
name: gamete
def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." []
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
is_a: CL:0000413 ! haploid cell
is_a: CL:0000586 ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: RO:0000053 PATO:0001375
intersection_of: RO:0002215 GO:0009566
[Term]
id: CL:0000301
name: pole cell
def: "A primordial germ cell of insects. Such cells form at the posterior pole of the early embryo." []
is_a: CL:0000670 ! primordial germ cell
[Term]
id: CL:0000306
name: crystallin accumulating cell
synonym: "lens cell" EXACT []
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000311
name: keratin accumulating cell
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000312
name: keratinocyte
def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." []
synonym: "keratinized cell of epidermis" EXACT []
synonym: "malpighian cell" EXACT []
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000237 ! keratinizing barrier epithelial cell
intersection_of: BFO:0000050 UBERON:0001003
relationship: RO:0002215 GO:0002775
relationship: RO:0002215 GO:0002776
relationship: RO:0002215 GO:0090023
[Term]
id: CL:0000314
name: milk secreting cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000317
name: sebum secreting cell
def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." []
synonym: "sebocyte" EXACT []
is_a: CL:0000151 ! secretory cell
is_a: CL:2000021 ! sebaceous gland cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0001821
[Term]
id: CL:0000319
name: mucus secreting cell
synonym: "mucous cell" EXACT []
is_a: CL:0000159 ! seromucus secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0070254
relationship: RO:0002215 GO:0070254
[Term]
id: CL:0000322
name: pneumocyte
def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." []
synonym: "alveolar epithelial cell" EXACT []
synonym: "pneumonocyte" EXACT []
is_a: CL:0000066 ! epithelial cell
relationship: BFO:0000050 UBERON:0004821
[Term]
id: CL:0000325
name: stuff accumulating cell
def: "A cell that is specialised to accumulate a particular substance(s)." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000327
name: extracellular matrix secreting cell
is_a: CL:0000499 ! stromal cell
[Term]
id: CL:0000329
name: oxygen accumulating cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0015671
[Term]
id: CL:0000333
name: migratory neural crest cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." []
is_a: CL:0000219 ! motile cell
is_a: CL:0011012 ! neural crest cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0007004 ! premigratory neural crest cell
[Term]
id: CL:0000338
name: neuroblast (sensu Nematoda and Protostomia)
def: "A neural precursor of the central nervous system." []
synonym: "neuroblast" BROAD []
is_a: CL:0000047 ! neural stem cell
relationship: RO:0002160 NCBITaxon:33317
[Term]
id: CL:0000339
name: glioblast (sensu Vertebrata)
def: "An early neural cell developing from the early ependymal cell of the neural tube." []
synonym: "spongioblast" EXACT []
is_a: CL:0000030 ! glioblast
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002160 NCBITaxon:7742
[Term]
id: CL:0000341
name: pigment cell (sensu Nematoda and Protostomia)
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000349
name: extraembryonic cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000478
[Term]
id: CL:0000350
name: amnioserosal cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: BFO:0000050 UBERON:0010302
[Term]
id: CL:0000351
name: trophoblast cell
def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." []
synonym: "trophoblastic cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell
relationship: BFO:0000050 UBERON:0000358
[Term]
id: CL:0000355
name: multi-potent skeletal muscle stem cell
def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." []
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000188 ! cell of skeletal muscle
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: BFO:0000050 UBERON:0001134
[Term]
id: CL:0000357
name: stratified epithelial stem cell
is_a: CL:0000036 ! epithelial fate stem cell
[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
def: "A smooth muscle cell associated with the vasculature." []
synonym: "vascular smooth muscle cell" EXACT []
synonym: "VSMC" EXACT []
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:4033054 ! perivascular cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002049
[Term]
id: CL:0000362
name: epidermal cell
def: "An epithelial cell of the integument (the outer layer of an organism)." []
synonym: "cell of epidermis" EXACT []
synonym: "epithelial cell of skin" NARROW []
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0007376
[Term]
id: CL:0000365
name: animal zygote
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." []
synonym: "zygote" BROAD []
is_a: CL:0000007 ! early embryonic cell (metazoa)
is_a: CL:0010017 ! zygote
intersection_of: CL:0010017 ! zygote
intersection_of: RO:0002160 NCBITaxon:33208
[Term]
id: CL:0000373
name: histoblast
def: "A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis." []
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002160 NCBITaxon:50557
[Term]
id: CL:0000385
name: prohemocyte (sensu Nematoda and Protostomia)
def: "A precursor of mature hemocytes." []
is_a: CL:0008001 ! hematopoietic precursor cell
[Term]
id: CL:0000386
name: attachment cell
is_a: CL:0000630 ! supporting cell
[Term]
id: CL:0000387
name: hemocyte (sensu Arthropoda)
def: "A blood cell of the circulatory system of arthropods." []
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)
relationship: RO:0002160 NCBITaxon:6656
relationship: RO:0002202 CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000388
name: tendon cell
def: "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." []
synonym: "muscle attachment cell" EXACT []
synonym: "tenocyte" RELATED []
is_a: CL:0000135 ! fibrocyte
is_a: CL:0000386 ! attachment cell
intersection_of: CL:0000135 ! fibrocyte
intersection_of: BFO:0000050 UBERON:0000043
[Term]
id: CL:0000390
name: blood cell (sensu Nematoda and Protostomia)
is_a: CL:0000081 ! blood cell
[Term]
id: CL:0000392
name: crystal cell
def: "A hemocyte that synthesizes and secretes melanins as part of the antimicrobial immune response. It is characterized morphologically by crystal inclusions of phenoloxidases in its cytoplasm, hence its name." []
is_a: CL:0000387 ! hemocyte (sensu Arthropoda)
relationship: RO:0002202 CL:0000395 ! procrystal cell
[Term]
id: CL:0000393
name: electrically responsive cell
def: "A cell whose function is determined by its response to an electric signal." []
is_a: CL:0000211 ! electrically active cell
[Term]
id: CL:0000394
name: plasmatocyte
def: "A phagocytic hemocyte, responsible for the engulfment of small particles, microbes, and apoptotic tissue debris. It may also secretes antimicrobial peptides and contribute to the production and secretion of proteins of the hemolymph." []
synonym: "macrophage" RELATED []
is_a: CL:0000387 ! hemocyte (sensu Arthropoda)
relationship: RO:0002215 GO:0035010
[Term]
id: CL:0000395
name: procrystal cell
def: "A precursor of mature crystal cells." []
is_a: CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000396
name: lamellocyte
def: "A hemocyte found in immuno-stimulated larvae." []
is_a: CL:0000387 ! hemocyte (sensu Arthropoda)
[Term]
id: CL:0000397
name: ganglion interneuron
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000045
[Term]
id: CL:0000402
name: CNS interneuron
def: "An interneuron that has its cell body in a central nervous system." []
is_a: CL:0000099 ! interneuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0001017
[Term]
id: CL:0000404
name: electrically signaling cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." []
is_a: CL:0000211 ! electrically active cell
[Term]
id: CL:0000408
name: male gamete
is_a: CL:0000015 ! male germ cell
is_a: CL:0000300 ! gamete
intersection_of: CL:0000015 ! male germ cell
intersection_of: RO:0000053 PATO:0001375
intersection_of: RO:0002215 GO:0009566
[Term]
id: CL:0000412
name: polyploid cell
def: "A cell that contains more than two haploid sets of chromosomes." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001377
[Term]
id: CL:0000413
name: haploid cell
def: "A cell whose nucleus contains a single haploid genome." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001375
[Term]
id: CL:0000417
name: endopolyploid cell
is_a: CL:0000412 ! polyploid cell
[Term]
id: CL:0000422
name: mitogenic signaling cell
def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000423
name: tip cell
is_a: CL:0000422 ! mitogenic signaling cell
[Term]
id: CL:0000424
name: excretory cell
def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." []
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000430
name: xanthophore cell
def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." []
synonym: "xanthophore" RELATED []
is_a: CL:0000147 ! pigment cell
relationship: RO:0002202 CL:0005002 ! xanthoblast
[Term]
id: CL:0000431
name: iridophore
def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." []
synonym: "guanophore" RELATED []
is_a: CL:0000147 ! pigment cell
relationship: RO:0002202 CL:0005001 ! iridoblast
[Term]
id: CL:0000438
name: luteinizing hormone secreting cell
def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0032275
[Term]
id: CL:0000439
name: prolactin secreting cell
def: "A peptide hormone cell that secretes prolactin." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0070459
[Term]
id: CL:0000440
name: melanocyte stimulating hormone secreting cell
def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." []
synonym: "melanotrope" EXACT []
synonym: "melanotroph" EXACT []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0036160
[Term]
id: CL:0000441
name: follicle stem cell (sensu Arthropoda)
def: "A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods." []
synonym: "somatic stem cell" BROAD []
is_a: CL:0000036 ! epithelial fate stem cell
relationship: RO:0002160 NCBITaxon:6656
[Term]
id: CL:0000442
name: follicular dendritic cell
def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." []
is_a: CL:0000473 ! defensive cell
[Term]
id: CL:0000443
name: calcitonin secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0036161
[Term]
id: CL:0000447
name: carbohydrate secreting cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000448
name: white adipocyte
def: "An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." []
synonym: "white adipose cell" EXACT []
synonym: "white fat cell" RELATED []
is_a: CL:0000136 ! adipocyte
relationship: BFO:0000050 UBERON:0001347
relationship: RO:0002202 CL:0002334 ! preadipocyte
[Term]
id: CL:0000449
name: brown adipocyte
def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." []
synonym: "brown adipose cell" EXACT []
synonym: "brown fat cell" EXACT []
is_a: CL:0000136 ! adipocyte
relationship: BFO:0000050 UBERON:0001348
relationship: RO:0002202 CL:0002335 ! brown preadipocyte
[Term]
id: CL:0000451
name: dendritic cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." []
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: BFO:0000051 GO:0042613
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: RO:0000053 PATO:0001407
intersection_of: RO:0002215 GO:0001816
intersection_of: RO:0002215 GO:0002504
intersection_of: RO:0002215 GO:0019882
intersection_of: RO:0002215 GO:0045580
disjoint_from: CL:0000542 ! lymphocyte
[Term]
id: CL:0000453
name: Langerhans cell
def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." []
synonym: "LC" EXACT []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0002104 PR:000001293
intersection_of: RO:0002215 GO:0002828
relationship: RO:0002202 CL:0000763 ! myeloid cell
[Term]
id: CL:0000454
name: epinephrine secreting cell
def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." []
synonym: "adrenaline secreting cell" EXACT []
synonym: "epinephrin secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0048242
[Term]
id: CL:0000456
name: mineralocorticoid secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035931
[Term]
id: CL:0000457
name: biogenic amine secreting cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000458
name: serotonin secreting cell
def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." []
synonym: "5-HT secreting cell" EXACT []
synonym: "5-Hydroxytryptamine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0001820
[Term]
id: CL:0000459
name: noradrenergic cell
def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." []
synonym: "noradrenaline secreting cell" EXACT []
synonym: "norepinephrin secreting cell" EXACT []
synonym: "norepinephrine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0048243
[Term]
id: CL:0000460
name: glucocorticoid secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035933
[Term]
id: CL:0000467
name: adrenocorticotropic hormone secreting cell
def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." []
synonym: "ACTH secreting cell" EXACT []
synonym: "adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "corticotrophin hormone secreting cell" EXACT []
synonym: "corticotropin hormone secreting cell" EXACT []
synonym: "corticotropin secreting cell" EXACT []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0051458
[Term]
id: CL:0000469
name: ganglion mother cell
def: "A neural progenitor cell that is the daughter of a neuroblast (sensu arthopoda). The progeny of ganglion mother cells develop into neurons, glia and (occasionally) epithelial cells." []
is_a: CL:0011020 ! neural progenitor cell
relationship: RO:0002202 CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)
[Term]
id: CL:0000473
name: defensive cell
def: "A cell whose primary function is to protect the organism." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000474
name: pericardial nephrocyte
def: "An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." []
synonym: "pericardial cell" NARROW []
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte
[Term]
id: CL:0000476
name: thyrotroph
def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." []
synonym: "beta-basophil" EXACT []
synonym: "thyroid stimulating hormone secreting cell" EXACT []
synonym: "thyrotrope" EXACT []
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis
relationship: RO:0002215 GO:0070460
[Term]
id: CL:0000477
name: follicle cell of egg chamber
def: "A somatic epithelial cell of the insect egg chamber." []
synonym: "follicle cell" BROAD []
synonym: "ovarian follicle cell" BROAD []
is_a: CL:0000500 ! follicular epithelial cell
is_a: CL:2000064 ! ovarian surface epithelial cell
relationship: BFO:0000050 UBERON:0000992
relationship: RO:0002160 NCBITaxon:50557
relationship: RO:0002202 CL:0000441 ! follicle stem cell (sensu Arthropoda)
[Term]
id: CL:0000482
name: juvenile hormone secreting cell
def: "An endocrine cell that secretes juvenile hormone." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0045443
[Term]
id: CL:0000484
name: connective tissue type mast cell
def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." []
synonym: "MC(TC)" EXACT []
synonym: "MCTC" EXACT []
synonym: "TC mast cells" EXACT []
is_a: CL:0000097 ! mast cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000097 ! mast cell
intersection_of: BFO:0000050 UBERON:0002384
[Term]
id: CL:0000485
name: mucosal type mast cell
def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." []
synonym: "MC(T)" EXACT []
synonym: "MCT" EXACT []
synonym: "T mast cells" EXACT []
is_a: CL:0000097 ! mast cell
intersection_of: CL:0000097 ! mast cell
intersection_of: BFO:0000050 UBERON:0001961
intersection_of: RO:0002215 GO:0002540
[Term]
id: CL:0000486
name: garland cell
def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." []
synonym: "garland nephrocyte" BROAD []
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte
[Term]
id: CL:0000487
name: oenocyte
def: "A secretory cell of ectodermal origin. This cell may have important functions in fatty acid and hydrocarbon metabolism and is metabolically linked to the fat body and tracheae. This cell is exclusive of arthropods." []
is_a: CL:0000151 ! secretory cell
relationship: RO:0002160 NCBITaxon:6656
[Term]
id: CL:0000488
name: visible light photoreceptor cell
def: "A photoreceptor cell that detects visible light." []
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: RO:0002215 GO:0009584
[Term]
id: CL:0000492
name: CD4-positive helper T cell
def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." []
synonym: "CD4-positive helper T lymphocyte" EXACT []
synonym: "CD4-positive helper T-cell" EXACT []
synonym: "CD4-positive helper T-lymphocyte" EXACT []
synonym: "CD4-positive T-helper cell" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0002215 GO:0001816
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: RO:0002353 GO:0030217
[Term]
id: CL:0000494
name: UV sensitive photoreceptor cell
def: "A photoreceptor cell that detects ultraviolet light." []
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: RO:0002215 GO:0009589
[Term]
id: CL:0000498
name: inhibitory interneuron
def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." []
is_a: CL:0000099 ! interneuron
[Term]
id: CL:0000499
name: stromal cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." []
is_a: CL:0002320 ! connective tissue cell
relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000500
name: follicular epithelial cell
def: "An epithelial somatic cell associated with a maturing oocyte." []
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000501
name: granulosa cell
def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." []
synonym: "granulosa cell of ovary" EXACT []
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002174 ! follicular cell of ovary
[Term]
id: CL:0000502
name: type D enteroendocrine cell
def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." []
synonym: "D cell" EXACT []
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000172 ! somatostatin secreting cell
relationship: RO:0002215 GO:0070253
[Term]
id: CL:0000511
name: androgen binding protein secreting cell
def: "A peptide hormone secreting cell that secretes androgen binding protein." []
is_a: CL:0000154 ! protein secreting cell
[Term]
id: CL:0000513
name: cardiac muscle myoblast
def: "A precursor cell destined to differentiate into cardiac muscle cell." []
synonym: "cardiac muscle progenitor cell" EXACT []
synonym: "cardiomyocyte progenitor cell" EXACT []
is_a: CL:0010021 ! cardiac myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: BFO:0000050 UBERON:0001133
intersection_of: RO:0002203 CL:0000746 ! cardiac muscle cell
[Term]
id: CL:0000514
name: smooth muscle myoblast
def: "A precursor cell destined to differentiate into smooth muscle myocytes." []
synonym: "myoblast, smooth muscle" EXACT []
synonym: "satellite cell" RELATED []
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0000192 ! smooth muscle cell
[Term]
id: CL:0000515
name: skeletal muscle myoblast
def: "A myoblast that differentiates into skeletal muscle fibers." []
synonym: "skeletal myoblast" EXACT []
is_a: CL:0000056 ! myoblast
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0008002 ! skeletal muscle fiber
relationship: RO:0002202 CL:0000355 ! multi-potent skeletal muscle stem cell
[Term]
id: CL:0000517
name: macrophage derived foam cell
def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." []
synonym: "lipophage" EXACT []
is_a: CL:0000891 ! foam cell
relationship: RO:0002202 CL:0000235 ! macrophage
[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
def: "A phagocyte in vertebrates that is able to phagocytosis." []
is_a: CL:0000234 ! phagocyte
relationship: RO:0002160 NCBITaxon:7742
[Term]
id: CL:0000519
name: phagocyte (sensu Nematoda and Protostomia)
def: "A phagocyte from organisms in the Nematoda or Protostomia clades." []
is_a: CL:0000234 ! phagocyte
[Term]
id: CL:0000520
name: prokaryotic cell
is_a: CL:0000000 ! cell
[Term]
id: CL:0000521
name: fungal cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002160 NCBITaxon:4751
[Term]
id: CL:0000525
name: syncytiotrophoblast cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." []
synonym: "plasmidotrophoblast cell" RELATED []
synonym: "syncytial trophoblast cell" EXACT []
synonym: "syncytiotrophoblastic cell" EXACT []
synonym: "syntrophoblast cell" RELATED []
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: RO:0000053 PATO:0001908
relationship: BFO:0000050 UBERON:0000371
[Term]
id: CL:0000526
name: afferent neuron
def: "A neuron which conveys sensory information centrally from the periphery." []
synonym: "input neuron" EXACT []
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000527
name: efferent neuron
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." []
synonym: "output neuron" EXACT []
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000530
name: primary neuron (sensu Teleostei)
def: "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." []
is_a: CL:0000540 ! neuron
relationship: RO:0002160 NCBITaxon:32443
[Term]
id: CL:0000531
name: primary sensory neuron (sensu Teleostei)
def: "A primary neuron (sensu Teleostei) that has a sensory function." []
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000530 ! primary neuron (sensu Teleostei)
intersection_of: CL:0000101 ! sensory neuron
intersection_of: CL:0000530 ! primary neuron (sensu Teleostei)
[Term]
id: CL:0000540
name: neuron
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." []
synonym: "nerve cell" EXACT []
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: RO:0002202 CL:0000031 {gci_filler="NCBITaxon:7742", gci_relation="RO:0002162"} ! neuroblast (sensu Vertebrata)
relationship: RO:0002215 GO:0019226
[Term]
id: CL:0000541
name: melanoblast
def: "A cell that originates from the neural crest and differentiates into a pigment cell." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000542
name: lymphocyte
def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." []
is_a: CL:0000842 ! mononuclear cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: BFO:0000051 CL:0017500 ! neutrophillic cytoplasm
intersection_of: BFO:0000051 GO:0000792
intersection_of: RO:0000053 PATO:0001407
intersection_of: RO:0000053 PATO:0040072
disjoint_from: CL:0000766 ! myeloid leukocyte
relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor
[Term]
id: CL:0000545
name: T-helper 1 cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." []
synonym: "helper T cell type 1" EXACT []
synonym: "T helper cells type 1" EXACT []
synonym: "T(H)-1 cell" EXACT []
synonym: "Th1 CD4+ T cell" EXACT []
synonym: "Th1 cell" EXACT []
synonym: "Th1 T cell" EXACT []
synonym: "Th1 T lymphocyte" EXACT []
synonym: "Th1 T-cell" EXACT []
synonym: "Th1 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: BFO:0000051 PR:000001835
intersection_of: lacks_plasma_membrane_part PR:000001202
intersection_of: RO:0002104 PR:000001207
intersection_of: RO:0002215 GO:0032609
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
[Term]
id: CL:0000546
name: T-helper 2 cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." []
synonym: "helper T cell type 2" EXACT []
synonym: "T helper cells type 2" EXACT []
synonym: "T(H)-2 cell" EXACT []
synonym: "Th2 cell" EXACT []
synonym: "Th2 T cell" EXACT []
synonym: "Th2 T lymphocyte" EXACT []
synonym: "Th2 T-cell" EXACT []
synonym: "Th2 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: BFO:0000051 PR:000001941
intersection_of: lacks_plasma_membrane_part PR:000001202
intersection_of: lacks_plasma_membrane_part PR:000001207
intersection_of: RO:0002215 GO:0032633
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
[Term]
id: CL:0000547
name: proerythroblast
def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." []
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT []
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm
intersection_of: BFO:0000051 GO:0005730
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: RO:0000053 PATO:0002505
intersection_of: RO:0000053 PATO:0040072
intersection_of: RO:0002104 PR:000001945
relationship: RO:0002202 CL:0000038 ! erythroid progenitor cell
[Term]
id: CL:0000549
name: basophilic erythroblast
def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." []
synonym: "basophilic normoblast" EXACT []
synonym: "early erythroblast" EXACT []
synonym: "early normoblast" EXACT []
synonym: "prorubricyte" EXACT []
is_a: CL:0000765 ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000792
intersection_of: RO:0002104 PR:000001945
relationship: RO:0002202 CL:0000547 ! proerythroblast
[Term]
id: CL:0000550
name: polychromatophilic erythroblast
def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." []
synonym: "intermediate erythroblast" EXACT []
synonym: "intermediate normoblast" EXACT []
synonym: "polychromatic erythroblast" EXACT []
synonym: "polychromatic normoblast" EXACT []
synonym: "polychromatophilic normoblast" EXACT []
synonym: "rubricyte" EXACT []
is_a: CL:0000765 ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017504 ! polychromatophilic cytoplasm
intersection_of: BFO:0000051 GO:0000792
intersection_of: RO:0002104 PR:000001945
relationship: RO:0002202 CL:0000549 ! basophilic erythroblast
[Term]
id: CL:0000552
name: orthochromatic erythroblast
def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." []
synonym: "acidophilic erythroblast" EXACT []
synonym: "eosinophilic erythroblast" EXACT []
synonym: "late erythoblast" EXACT []
synonym: "orthochromatic normoblast" EXACT []
synonym: "pyknotic eto enrythroblast" EXACT []
is_a: CL:0000765 ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017502 ! acidophilic cytoplasm
intersection_of: RO:0000056 GO:0030263
relationship: RO:0002202 CL:0000550 ! polychromatophilic erythroblast
[Term]
id: CL:0000553
name: megakaryocyte progenitor cell
def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." []
synonym: "CFU-Meg" EXACT []
synonym: "colony-forming unit-megakaryocyte" EXACT []
synonym: "Meg-CFC" EXACT []
synonym: "megacaryoblast" EXACT []
synonym: "megacaryocyte progenitor cell" EXACT []
synonym: "megakaryoblast" EXACT []
synonym: "megakaryocytic progenitor cell" EXACT []
synonym: "MkP" EXACT []
synonym: "promegacaryocyte" RELATED []
synonym: "promegakaryocyte" RELATED []
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002215 GO:0007113
intersection_of: RO:0002215 GO:0030219
relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell
[Term]
id: CL:0000556
name: megakaryocyte
def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." []
synonym: "megacaryocyte" EXACT []
synonym: "megalocaryocyte" EXACT []
synonym: "megalokaryocyte" EXACT []
is_a: CL:0000763 ! myeloid cell
disjoint_from: CL:0000764 ! erythroid lineage cell
relationship: RO:0000053 PATO:0001393
relationship: RO:0002202 CL:0000553 ! megakaryocyte progenitor cell
[Term]
id: CL:0000557
name: granulocyte monocyte progenitor cell
def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." []
synonym: "CFU-C , Colony forming unit in culture" BROAD []
synonym: "CFU-GM" RELATED []
synonym: "colony forming unit granulocyte macrophage" EXACT []
synonym: "GMP" RELATED []
synonym: "granulocyte-macrophage progenitor" EXACT []
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: BFO:0000050 UBERON:0002371
intersection_of: BFO:0000051 PR:000001944
intersection_of: BFO:0000051 PR:000005307
intersection_of: lacks_part PR:000007857
intersection_of: lacks_part PR:000007858
intersection_of: RO:0002104 PR:000001865
intersection_of: RO:0002215 GO:0030225
intersection_of: RO:0002215 GO:0030851
relationship: RO:0002202 CL:0000049 ! common myeloid progenitor
[Term]
id: CL:0000558
name: reticulocyte
def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." []
is_a: CL:0000764 ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: RO:0002104 PR:000001945
intersection_of: RO:0002215 GO:0071971
relationship: RO:0002202 CL:0000552 ! orthochromatic erythroblast
[Term]
id: CL:0000559
name: promonocyte
def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." []
is_a: CL:0002194 ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: BFO:0000051 GO:0042582
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002215 GO:0030224
relationship: RO:0002202 CL:0000040 ! monoblast
[Term]
id: CL:0000561
name: amacrine cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." []
synonym: "AC" RELATED []
synonym: "ACs" RELATED []
synonym: "amacrine neuron" EXACT []
is_a: CL:0000099 ! interneuron
relationship: BFO:0000050 UBERON:0000966
relationship: RO:0002120 CL:0000740 ! retinal ganglion cell
relationship: RO:0002162 NCBITaxon:7742
[Term]
id: CL:0000562
name: nucleate erythrocyte
def: "An erythrocyte having a nucleus." []
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000232 ! erythrocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000232 ! erythrocyte
intersection_of: RO:0000053 PATO:0002505
relationship: RO:0002202 CL:0002421 ! nucleated reticulocyte
[Term]
id: CL:0000563
name: endospore
def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." []
synonym: "bacterial spore" EXACT []
is_a: CL:0000520 ! prokaryotic cell
[Term]
id: CL:0000564
name: neutrophilic promyelocyte
def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." []
synonym: "neutrophilic premyelocyte" EXACT []
synonym: "neutrophilic progranulocyte" EXACT []
is_a: CL:0000834 ! neutrophil progenitor cell
is_a: CL:0000836 ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: BFO:0000051 PR:000001944
intersection_of: BFO:0000051 PR:000005307
intersection_of: BFO:0000051 PR:000007857
intersection_of: BFO:0000051 PR:000010543
intersection_of: BFO:0000051 PR:000014362
intersection_of: lacks_part PR:000009978
intersection_of: RO:0002215 GO:0030223
relationship: RO:0002202 CL:0000042 ! neutrophilic myeloblast
[Term]
id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." []
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: RO:0002104 PR:000001444
intersection_of: RO:0002104 PR:000002112
intersection_of: RO:0002104 PR:000016043
relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000568
name: amine precursor uptake and decarboxylation cell
def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." []
synonym: "APUD cell" EXACT []
is_a: CL:0000165 ! neuroendocrine cell
[Term]
id: CL:0000569
name: cardiac mesenchymal cell
def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." []
is_a: CL:0008019 ! mesenchymal cell
is_a: CL:2000073 ! migratory cardiac neural crest cell
intersection_of: CL:0008019 ! mesenchymal cell
intersection_of: RO:0002203 CL:0002494 ! cardiocyte
[Term]
id: CL:0000570
name: parafollicular cell
def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." []
synonym: "C cell" EXACT []
synonym: "C cell of thyroid gland" EXACT []
synonym: "clear cell of thyroid gland" EXACT []
synonym: "parafollicular cell of thyroid gland" EXACT []
synonym: "thyroid parafollicular cell" EXACT []
is_a: CL:0000443 ! calcitonin secreting cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: RO:0002104 PR:000001024
intersection_of: RO:0002215 GO:0001820
intersection_of: RO:0002215 GO:0014046
intersection_of: RO:0002215 GO:0036161
relationship: BFO:0000050 UBERON:0001747
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000571
name: leucophore
def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." []
is_a: CL:0000147 ! pigment cell
relationship: RO:0002202 CL:0005003 ! leucoblast
[Term]
id: CL:0000573
name: retinal cone cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." []
synonym: "cone" RELATED []
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: RO:0002202 CL:0002672 ! retinal progenitor cell
[Term]
id: CL:0000574
name: erythrophore
def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." []
is_a: CL:0000147 ! pigment cell
relationship: RO:0002202 CL:0005004 ! pigment erythroblast
[Term]
id: CL:0000575
name: corneal epithelial cell
def: "An epithelial cell of the cornea." []
synonym: "epithelial cell of cornea" EXACT []
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: BFO:0000050 UBERON:0001772
[Term]
id: CL:0000576
name: monocyte
def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." []
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: RO:0000053 PATO:0001407
intersection_of: RO:0002215 GO:0030225
intersection_of: RO:0002215 GO:0030316
intersection_of: RO:0002215 GO:0043011
relationship: RO:0002202 CL:0000559 ! promonocyte
[Term]
id: CL:0000579
name: border follicle cell
def: "A follicle cell that migrates from the anterior pole of the insect egg chamber to the anterior of the oocyte where they participate in the formation of the micropyle." []
is_a: CL:0000477 ! follicle cell of egg chamber
[Term]
id: CL:0000584
name: enterocyte
def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." []
synonym: "differentiated enterocyte" NARROW []
synonym: "mature enterocyte" NARROW []
is_a: CL:0000239 ! brush border epithelial cell
is_a: CL:0000677 ! gut absorptive cell
is_a: CL:0002563 ! intestinal epithelial cell
[Term]
id: CL:0000586
name: germ cell
def: "The reproductive cell in multicellular organisms." []
is_a: CL:0000039 ! germ line cell
relationship: RO:0002216 GO:0009566
[Term]
id: CL:0000588
name: odontoclast
def: "A specialized osteoclast associated with the absorption and removal of cementum." []
is_a: CL:0000092 ! osteoclast
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0002215 GO:0042483
[Term]
id: CL:0000593
name: androgen secreting cell
def: "A steroid hormone secreting cell that secretes androgen." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035935
[Term]
id: CL:0000594
name: skeletal muscle satellite cell
def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." []
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000680 ! muscle precursor cell
relationship: BFO:0000050 UBERON:0001134
[Term]
id: CL:0000595
name: enucleate erythrocyte
def: "An erythrocyte lacking a nucleus." []
synonym: "RBC" RELATED []
synonym: "red blood cell" BROAD []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000232 ! erythrocyte
intersection_of: CL:0000232 ! erythrocyte
intersection_of: RO:0000053 PATO:0001405
relationship: RO:0002202 CL:0002422 ! enucleated reticulocyte
[Term]
id: CL:0000596
name: sexual spore
def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." []
synonym: "meiotically-derived spore" EXACT []
is_a: CL:0002369 ! fungal spore
[Term]
id: CL:0000598
name: pyramidal neuron
def: "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." []
synonym: "projection neuron" EXACT []
synonym: "pyramidal cell" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0000053 PATO:0070015
[Term]
id: CL:0000599
name: conidium
def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." []
is_a: CL:0000605 ! fungal asexual spore
[Term]
id: CL:0000601
name: cochlear outer hair cell
def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." []
is_a: CL:4023120 ! cochlea auditory hair cell
relationship: BFO:0000050 UBERON:0002227
[Term]
id: CL:0000604
name: retinal rod cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." []
synonym: "rod" RELATED []
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: RO:0002202 CL:0002672 ! retinal progenitor cell
[Term]
id: CL:0000605
name: fungal asexual spore
def: "A spore formed following mitosis or mitoses." []
is_a: CL:0002369 ! fungal spore
[Term]
id: CL:0000606
name: macroconidium
def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." []
is_a: CL:0000599 ! conidium
[Term]
id: CL:0000607
name: ascospore
def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." []
is_a: CL:0000596 ! sexual spore
[Term]
id: CL:0000608
name: zygospore
def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." []
is_a: CL:0000596 ! sexual spore
[Term]
id: CL:0000609
name: vestibular hair cell
def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." []
synonym: "vestibular receptor cell" EXACT []
is_a: CL:0002374 ! ear hair cell
[Term]
id: CL:0000611
name: eosinophil progenitor cell
synonym: "CFU-Eo" RELATED []
synonym: "colony forming unit eosinophil" RELATED []
synonym: "EoP" RELATED []
synonym: "eosinophil stem cell" RELATED []
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: BFO:0000051 PR:000001944
intersection_of: BFO:0000051 PR:000005307
intersection_of: BFO:0000051 PR:000007857
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002104 PR:000001865
intersection_of: RO:0002104 PR:000001867
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002215 GO:0030222
relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell
[Term]
id: CL:0000612
name: eosinophilic myelocyte
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." []
is_a: CL:0000772 ! immature eosinophil
is_a: CL:0002193 ! myelocyte
intersection_of: CL:0000772 ! immature eosinophil
intersection_of: BFO:0000051 GO:0042582
intersection_of: lacks_part GO:0070820
intersection_of: lacks_plasma_membrane_part PR:000001483
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001456
intersection_of: RO:0002104 PR:000001892
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002031
[Term]
id: CL:0000613
name: basophil progenitor cell
def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." []
synonym: "BaP" EXACT []
synonym: "basophilic stem cell" RELATED []
synonym: "CFU-Bas" RELATED []
synonym: "colony forming unit basophil" RELATED []
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: BFO:0000051 PR:000005307
intersection_of: BFO:0000051 PR:000007857
intersection_of: BFO:0000051 PR:000007858
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002065
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002215 GO:0030221
intersection_of: RO:0015015 PR:000007431
intersection_of: RO:0015016 PR:000016401
relationship: RO:0002202 CL:0002028 ! basophil mast progenitor cell
[Term]
id: CL:0000614
name: basophilic myelocyte
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." []
is_a: CL:0000768 ! immature basophil
intersection_of: CL:0000768 ! immature basophil
intersection_of: BFO:0000051 GO:0042582
intersection_of: lacks_part GO:0005730
intersection_of: lacks_part GO:0070820
intersection_of: lacks_plasma_membrane_part PR:000001483
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001456
intersection_of: RO:0002104 PR:000001892
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002031
relationship: RO:0002202 CL:0000830 ! basophilic promyelocyte
[Term]
id: CL:0000615
name: basidiospore
def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." []
is_a: CL:0000596 ! sexual spore
[Term]
id: CL:0000617
name: GABAergic neuron
def: "A neuron that uses GABA as a vesicular neurotransmitter" []
synonym: "GABA-ergic neuron" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061534
[Term]
id: CL:0000622
name: acinar cell
def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." []
synonym: "acinic cell" EXACT []
synonym: "acinous cell" EXACT []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000154 ! protein secreting cell
relationship: BFO:0000050 UBERON:0009842
[Term]
id: CL:0000623
name: natural killer cell
def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." []
synonym: "large granular lymphocyte" BROAD []
synonym: "NK cell" EXACT []
synonym: "null cell" BROAD []
is_a: CL:0001067 ! group 1 innate lymphoid cell
intersection_of: CL:0001067 ! group 1 innate lymphoid cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: RO:0002215 GO:0002228
intersection_of: RO:0002215 GO:0050776
relationship: RO:0002202 CL:0000825 ! pro-NK cell
[Term]
id: CL:0000624
name: CD4-positive, alpha-beta T cell
def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." []
synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta T-cell" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000025402
intersection_of: RO:0002104 PR:000001004
disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell
[Term]
id: CL:0000625
name: CD8-positive, alpha-beta T cell
def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." []
synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta T-cell" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: RO:0002104 PR:000025402
[Term]
id: CL:0000630
name: supporting cell
def: "A cell whose primary function is to support other cell types." []
synonym: "supportive cell" EXACT []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000632
name: hepatic stellate cell
def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." []
synonym: "fat-storing cell" RELATED []
synonym: "hepatic perisinusoidal cell" EXACT []
synonym: "Ito cell" EXACT []
synonym: "lipocyte" RELATED []
synonym: "perisinusoidal cell" EXACT []
synonym: "vitamin A-storing cells" RELATED []
is_a: CL:0000057 ! fibroblast
is_a: CL:0000327 ! extracellular matrix secreting cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: BFO:0000050 UBERON:0002107
intersection_of: RO:0002104 PR:000007939
[Term]
id: CL:0000637
name: chromophil cell of anterior pituitary gland
def: "A cell that stains readily in the anterior pituitary gland." []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000166 ! chromaffin cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0002196
relationship: RO:0002215 GO:0030072
[Term]
id: CL:0000639
name: basophil cell of pars distalis of adenohypophysis
def: "A basophilic chromophil cell that of the anterior pituitary gland." []
synonym: "basophil cell of anterior lobe of hypophysis" EXACT []
synonym: "beta cell" RELATED []
synonym: "pituitary beta cell" RELATED []
is_a: CL:0000637 ! chromophil cell of anterior pituitary gland
[Term]
id: CL:0000644
name: Bergmann glial cell
def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." []
synonym: "Bergmann astrocyte" EXACT []
synonym: "Bergmann glial cell of cerebellum" EXACT []
is_a: CL:0000127 ! astrocyte
[Term]
id: CL:0000646
name: basal cell
def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." []
is_a: CL:0000036 ! epithelial fate stem cell
[Term]
id: CL:0000647
name: multinucleated giant cell
def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." []
synonym: "foreign body giant cell" EXACT []
synonym: "Langerhans giant cell" EXACT []
synonym: "macrophage polykaryon" EXACT []
synonym: "multinucleate giant cell" EXACT []
synonym: "syncytial giant cell" EXACT []
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: RO:0000053 PATO:0001908
intersection_of: RO:0000056 GO:0002432
intersection_of: RO:0000056 GO:0002544
relationship: RO:0002202 CL:0000235 ! macrophage
[Term]
id: CL:0000648
name: kidney granular cell
def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." []
synonym: "JG cell" EXACT []
synonym: "juxtaglomerular cell" BROAD []
synonym: "renin secreting cell" EXACT []
is_a: CL:0000151 ! secretory cell
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:1000497 ! kidney cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0002113
intersection_of: RO:0002215 GO:0002001
relationship: BFO:0000050 UBERON:0002303
[Term]
id: CL:0000650
name: mesangial cell
def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." []
synonym: "kidney mesangial cell" EXACT []
is_a: CL:0000669 ! pericyte
relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000653
name: podocyte
def: "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes." []
synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD []
synonym: "glomerular podocyte" EXACT []
synonym: "glomerular visceral epithelial cell" EXACT []
synonym: "kidney podocyte" EXACT []
synonym: "renal podocyte" EXACT []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002522 ! renal filtration cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005751
[Term]
id: CL:0000654
name: primary oocyte
def: "A primary oocyte is an oocyte that has not completed female meosis I." []
synonym: "primary oogonium" RELATED []
is_a: CL:0000023 ! oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: has_not_completed GO:0051321
relationship: RO:0002202 CL:0000024 ! oogonial cell
[Term]
id: CL:0000655
name: secondary oocyte
def: "A secondary oocyte is an oocyte that has not completed meiosis II." []
synonym: "primary oogonium" RELATED []
is_a: CL:0000023 ! oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: has_not_completed GO:0007147
relationship: RO:0002202 CL:0000654 ! primary oocyte
[Term]
id: CL:0000656
name: primary spermatocyte
def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." []
is_a: CL:0000017 ! spermatocyte
intersection_of: CL:0000017 ! spermatocyte
intersection_of: RO:0000053 PATO:0001394
intersection_of: RO:0002215 GO:0007140
[Term]
id: CL:0000657
name: secondary spermatocyte
def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." []
is_a: CL:0000017 ! spermatocyte
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: RO:0000053 PATO:0001375
intersection_of: RO:0002215 GO:0007142
relationship: RO:0002202 CL:0000656 ! primary spermatocyte
[Term]
id: CL:0000661
name: distal tip cell (sensu Nematoda)
is_a: CL:0000422 ! mitogenic signaling cell
[Term]
id: CL:0000666
name: fenestrated cell
synonym: "window cell" EXACT []
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000667
name: collagen secreting cell
def: "An extracellular matrix secreting cell that secretes collagen." []
is_a: CL:0000327 ! extracellular matrix secreting cell
[Term]
id: CL:0000669
name: pericyte
def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." []
synonym: "adventitial cell" RELATED []
synonym: "adventitial reticular cell" EXACT []
synonym: "ARC" EXACT []
synonym: "cell of Rouget" EXACT []
synonym: "pericyte cell" EXACT []
synonym: "pericyte of Rouget" EXACT []
is_a: CL:0000183 ! contractile cell
is_a: CL:0000630 ! supporting cell
is_a: CL:0002320 ! connective tissue cell
is_a: CL:0008034 ! mural cell
[Term]
id: CL:0000670
name: primordial germ cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." []
synonym: "gonocyte" EXACT []
synonym: "primitive germ cell" EXACT []
is_a: CL:0000039 ! germ line cell
is_a: CL:0000219 ! motile cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: BFO:0000050 UBERON:0000922
intersection_of: RO:0002215 GO:0048870
[Term]
id: CL:0000671
name: centripetally migrating follicle cell
def: "A follicle cell that migrates from the dorso-anterior part of the oocyte associated follicular epithelium, in between the nurse cells and the oocyte, and participates in the formation of the operculum." []
synonym: "centripetal follicle cell" EXACT []
is_a: CL:0000477 ! follicle cell of egg chamber
[Term]
id: CL:0000675
name: female gamete
def: "A mature sexual reproductive cell of the female germline." []
is_a: CL:0000021 ! female germ cell
is_a: CL:0000300 ! gamete
[Term]
id: CL:0000677
name: gut absorptive cell
def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." []
is_a: CL:0000000 ! cell
relationship: BFO:0000050 UBERON:0001277
[Term]
id: CL:0000678
name: commissural neuron
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000679
name: glutamatergic neuron
def: "A neuron that is capable of some neurotansmission by glutamate secretion." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061535
[Term]
id: CL:0000680
name: muscle precursor cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." []
is_a: CL:0000055 ! non-terminally differentiated cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: RO:0002203 CL:0000187 ! muscle cell
relationship: RO:0002202 CL:0000222 ! mesodermal cell
[Term]
id: CL:0000681
name: radial glial cell
def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." []
synonym: "forebrain radial glial cell" NARROW []
is_a: CL:0000125 ! glial cell
relationship: RO:0002202 CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000683
name: ependymoglial cell
def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." []
synonym: "ependymal astrocyte" EXACT []
is_a: CL:0000127 ! astrocyte
[Term]
id: CL:0000686
name: cerebrospinal fluid secreting cell
def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." []
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0033326
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000691
name: stellate interneuron
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0000053 PATO:0070010
[Term]
id: CL:0000695
name: Cajal-Retzius cell
def: "A neuron of the human embryonic marginal zone which display, as a salient feature, radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. One feature of these cells in mammals is that they express the Reelin gene." []
synonym: "CR cells" EXACT []
synonym: "Horizontal cells of Cajal" EXACT []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
relationship: RO:0000053 PATO:0070006
relationship: RO:0002100 UBERON:0010403
[Term]
id: CL:0000696
name: PP cell
def: "A cell that stores and secretes pancreatic polypeptide hormone." []
synonym: "type F enteroendocrine cell" EXACT []
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000700
name: dopaminergic neuron
def: "A neuron that releases dopamine as a neurotransmitter." []
synonym: "dopaminergic cell" EXACT []
is_a: CL:4033050 ! catecholaminergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061527
[Term]
id: CL:0000704
name: endothelial tip cell
def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." []
is_a: CL:0000071 ! blood vessel endothelial cell
[Term]
id: CL:0000707
name: R7 photoreceptor cell
synonym: "R7 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000494 ! UV sensitive photoreceptor cell
[Term]
id: CL:0000708
name: leptomeningeal cell
def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." []
synonym: "leptomemingeal cell" RELATED []
is_a: CL:0000327 ! extracellular matrix secreting cell
intersection_of: CL:0000327 ! extracellular matrix secreting cell
intersection_of: BFO:0000050 UBERON:0003210
[Term]
id: CL:0000709
name: R8 photoreceptor cell
synonym: "R8 cell" EXACT []
is_a: CL:0000488 ! visible light photoreceptor cell
relationship: BFO:0000050 UBERON:0000971
[Term]
id: CL:0000710
name: neurecto-epithelial cell
def: "Epithelial cells derived from neural plate and neural crest." []
synonym: "neuroepithelial cell" BROAD []
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002077 ! ecto-epithelial cell
intersection_of: CL:0002077 ! ecto-epithelial cell
intersection_of: RO:0002202 CL:0000133 ! neurectodermal cell
[Term]
id: CL:0000711
name: cumulus cell
def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." []
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0002174 ! follicular cell of ovary
relationship: RO:0002202 CL:0000501 ! granulosa cell
[Term]
id: CL:0000715
name: embryonic crystal cell
def: "A crystal cell that derives from the embryonic head mesoderm." []
is_a: CL:0000392 ! crystal cell
is_a: CL:0011008 ! embryonic hemocyte
[Term]
id: CL:0000716
name: lymph gland crystal cell
def: "A crystal cell that derives from the larval lymph gland." []
is_a: CL:0000392 ! crystal cell
is_a: CL:0000735 ! lymph gland hemocyte
[Term]
id: CL:0000718
name: compound eye cone cell
def: "A cell of an ommatidium that secretes lens materials." []
synonym: "cone cell (sensu Endopterygota)" RELATED []
synonym: "Semper cell" EXACT []
is_a: CL:0000306 ! crystallin accumulating cell
relationship: BFO:0000050 UBERON:0000971
[Term]
id: CL:0000722
name: cystoblast
is_a: CL:0000586 ! germ cell
relationship: RO:0002160 NCBITaxon:6656
[Term]
id: CL:0000723
name: somatic stem cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." []
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000034 ! stem cell
intersection_of: RO:0002215 GO:0048103
[Term]
id: CL:0000724
name: heterocyst
def: "A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." []
is_a: CL:0000520 ! prokaryotic cell
is_a: CL:0000725 ! nitrogen fixing cell
[Term]
id: CL:0000725
name: nitrogen fixing cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0009399
[Term]
id: CL:0000726
name: chlamydospore
def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." []
is_a: CL:0000605 ! fungal asexual spore
[Term]
id: CL:0000730
name: leading edge cell
def: "A cell at the front of a migrating epithelial sheet." []
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000731
name: urothelial cell
def: "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria." []
synonym: "urinary tract transitional epithelial cell" NARROW []
is_a: CL:0000244 ! transitional epithelial cell
intersection_of: CL:0000244 ! transitional epithelial cell
intersection_of: BFO:0000050 UBERON:0000365
[Term]
id: CL:0000733
name: lymph gland plasmatocyte
def: "A plasmatocyte that derives from the larval lymph gland." []
is_a: CL:0000394 ! plasmatocyte
is_a: CL:0000735 ! lymph gland hemocyte
[Term]
id: CL:0000735
name: lymph gland hemocyte
def: "A hemocyte that derives from the larval lymph gland." []
is_a: CL:0000387 ! hemocyte (sensu Arthropoda)
[Term]
id: CL:0000737
name: striated muscle cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." []
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000051 GO:0030017
intersection_of: RO:0000053 PATO:0001410
disjoint_from: CL:0008000 ! non-striated muscle cell
[Term]
id: CL:0000738
name: leukocyte
def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." []
synonym: "immune cell" RELATED []
synonym: "leucocyte" EXACT []
synonym: "white blood cell" EXACT []
is_a: CL:0000988 ! hematopoietic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0002505
intersection_of: RO:0002215 GO:0001667
relationship: BFO:0000050 UBERON:0002405
relationship: RO:0002160 NCBITaxon:7742
relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell
[Term]
id: CL:0000740
name: retinal ganglion cell
def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." []
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
synonym: "RGC" RELATED []
synonym: "RGCs" RELATED []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
relationship: RO:0002100 UBERON:0000966
[Term]
id: CL:0000746
name: cardiac muscle cell
def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." []
synonym: "cardiac muscle fiber" EXACT []
synonym: "cardiac myocyte" EXACT []
synonym: "cardiocyte" BROAD []
synonym: "cardiomyocyte" EXACT []
synonym: "heart muscle cell" EXACT []
is_a: CL:0000187 ! muscle cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0007100
intersection_of: BFO:0000051 GO:0030017
intersection_of: RO:0000053 PATO:0002478
intersection_of: RO:0000056 GO:0060047
relationship: RO:0002202 CL:0000513 ! cardiac muscle myoblast
[Term]
id: CL:0000747
name: cyanophore
def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." []
synonym: "blue chromatophore" RELATED []
is_a: CL:0000147 ! pigment cell
relationship: RO:0002202 CL:0005005 ! cyanoblast
[Term]
id: CL:0000748
name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." []
synonym: "BC" RELATED []
synonym: "BCs" RELATED []
synonym: "BPs" RELATED []
is_a: CL:0000103 ! bipolar neuron
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0008028 ! visual system neuron
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000103 ! bipolar neuron
intersection_of: RO:0002100 UBERON:0001791
relationship: RO:0002216 GO:0007601
[Term]
id: CL:0000749
name: ON-bipolar cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." []
is_a: CL:0000748 ! retinal bipolar neuron
[Term]
id: CL:0000751
name: rod bipolar cell
def: "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." []
is_a: CL:0000749 ! ON-bipolar cell
relationship: RO:0002102 UBERON:0008925
relationship: RO:0002102 UBERON:0008926
relationship: RO:0002103 CL:0000604 ! retinal rod cell
relationship: RO:0002160 NCBITaxon:40674
[Term]
id: CL:0000752
name: cone retinal bipolar cell
def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." []
is_a: CL:0000748 ! retinal bipolar neuron
intersection_of: CL:0000748 ! retinal bipolar neuron
intersection_of: RO:0002103 CL:0000573 ! retinal cone cell
[Term]
id: CL:0000762
name: nucleated thrombocyte
def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." []
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000763 ! myeloid cell
intersection_of: RO:0000053 PATO:0001407
intersection_of: RO:0002215 GO:0007596
relationship: RO:0002202 CL:0000828 ! thromboblast
[Term]
id: CL:0000763
name: myeloid cell
def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." []
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0002202 CL:0000049 ! common myeloid progenitor
[Term]
id: CL:0000764
name: erythroid lineage cell
def: "A immature or mature cell in the lineage leading to and including erythrocytes." []
synonym: "erythropoietic cell" EXACT []
is_a: CL:0000763 ! myeloid cell
[Term]
id: CL:0000765
name: erythroblast
def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." []
synonym: "normoblast" EXACT []
is_a: CL:0000764 ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: BFO:0000051 GO:0005634
intersection_of: lacks_part GO:0005730
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: RO:0002215 GO:0030218
relationship: RO:0002202 CL:0000547 ! proerythroblast
[Term]
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." []
is_a: CL:0000738 ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: RO:0002202 CL:0000049 ! common myeloid progenitor
[Term]
id: CL:0000767
name: basophil
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." []
synonym: "basophilic leucocyte" EXACT []
synonym: "basophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000094 ! granulocyte
intersection_of: CL:0000094 ! granulocyte
intersection_of: RO:0002104 PR:000001344
intersection_of: RO:0002104 PR:000001950
intersection_of: RO:0015015 PR:000001255
intersection_of: RO:0015015 PR:000001865
intersection_of: RO:0015015 PR:000007431
[Term]
id: CL:0000768
name: immature basophil
def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." []
synonym: "immature basophilic leucocyte" EXACT []
synonym: "immature basophilic leukocyte" EXACT []
is_a: CL:0000767 ! basophil
intersection_of: CL:0000767 ! basophil
intersection_of: BFO:0000051 CL:0017509 ! alobate nucleus
relationship: RO:0002202 CL:0000830 ! basophilic promyelocyte
[Term]
id: CL:0000769
name: basophilic metamyelocyte
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." []
is_a: CL:0000768 ! immature basophil
is_a: CL:0002192 ! metamyelocyte
intersection_of: CL:0000768 ! immature basophil
intersection_of: BFO:0000051 CL:0017507 ! reniform nucleus
intersection_of: BFO:0000051 GO:0000792
intersection_of: BFO:0000051 GO:0042582
intersection_of: BFO:0000051 GO:0070820
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001456
intersection_of: RO:0002104 PR:000001483
intersection_of: RO:0002104 PR:000001892
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002031
relationship: RO:0002202 CL:0000614 ! basophilic myelocyte
[Term]
id: CL:0000770
name: band form basophil
def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." []
is_a: CL:0000768 ! immature basophil
intersection_of: CL:0000768 ! immature basophil
intersection_of: BFO:0000051 CL:0017506 ! banded nucleus
relationship: RO:0002202 CL:0000769 ! basophilic metamyelocyte
[Term]
id: CL:0000771
name: eosinophil
def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." []
synonym: "eosinocyte" EXACT []
synonym: "eosinophilic granulocyte" EXACT []
synonym: "eosinophilic leucocyte" EXACT []
synonym: "eosinophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000094 ! granulocyte
intersection_of: CL:0000094 ! granulocyte
intersection_of: RO:0002104 PR:000001254
intersection_of: RO:0002104 PR:000001255
intersection_of: RO:0002104 PR:000001307
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002104 PR:000005178
[Term]
id: CL:0000772
name: immature eosinophil
def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." []
synonym: "immature eosinocyte" EXACT []
synonym: "immature eosinophilic leucocyte" EXACT []
synonym: "immature eosinophilic leukocyte" EXACT []
is_a: CL:0000771 ! eosinophil
intersection_of: CL:0000771 ! eosinophil
intersection_of: BFO:0000051 CL:0017509 ! alobate nucleus
relationship: RO:0002202 CL:0000833 ! eosinophilic promyelocyte
[Term]
id: CL:0000773
name: eosinophilic metamyelocyte
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." []
is_a: CL:0000772 ! immature eosinophil
is_a: CL:0002192 ! metamyelocyte
intersection_of: CL:0000772 ! immature eosinophil
intersection_of: BFO:0000051 CL:0017502 ! acidophilic cytoplasm
intersection_of: BFO:0000051 CL:0017507 ! reniform nucleus
intersection_of: BFO:0000051 GO:0000792
intersection_of: BFO:0000051 GO:0042582
intersection_of: BFO:0000051 GO:0070820
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001456
intersection_of: RO:0002104 PR:000001483
intersection_of: RO:0002104 PR:000001892
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002031
relationship: RO:0002202 CL:0000612 ! eosinophilic myelocyte
[Term]
id: CL:0000774
name: band form eosinophil
def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil." []
is_a: CL:0000772 ! immature eosinophil
intersection_of: CL:0000772 ! immature eosinophil
intersection_of: BFO:0000051 CL:0017506 ! banded nucleus
relationship: RO:0002202 CL:0000773 ! eosinophilic metamyelocyte
[Term]
id: CL:0000775
name: neutrophil
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." []
synonym: "neutrocyte" EXACT []
synonym: "neutrophil leucocyte" EXACT []
synonym: "neutrophil leukocyte" EXACT []
synonym: "neutrophilic leucocyte" EXACT []
synonym: "neutrophilic leukocyte" EXACT []
synonym: "PMN" BROAD []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" BROAD []
synonym: "polynuclear neutrophilic leucocyte" BROAD []
synonym: "polynuclear neutrophilic leukocyte" BROAD []
is_a: CL:0000094 ! granulocyte
intersection_of: CL:0000094 ! granulocyte
intersection_of: RO:0002104 PR:000001479
intersection_of: RO:0002104 PR:000001879
[Term]
id: CL:0000776
name: immature neutrophil
def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." []
synonym: "immatuer neutrophilic leukocyte" EXACT []
synonym: "immature neutrocyte" EXACT []
synonym: "immature neutrophil leucocyte" EXACT []
synonym: "immature neutrophil leukocyte" EXACT []
synonym: "immature neutrophilic leucocyte" EXACT []
is_a: CL:0000775 ! neutrophil
intersection_of: CL:0000775 ! neutrophil
intersection_of: BFO:0000051 CL:0017509 ! alobate nucleus
relationship: RO:0002202 CL:0000564 ! neutrophilic promyelocyte
[Term]
id: CL:0000777
name: mesangial phagocyte
def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." []
synonym: "mesangial cell" BROAD []
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: RO:0001025 UBERON:0002320
intersection_of: RO:0002215 GO:0019882
intersection_of: RO:0002215 GO:0048771
[Term]
id: CL:0000778
name: mononuclear osteoclast
def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." []
is_a: CL:0000092 ! osteoclast
is_a: CL:0000113 ! mononuclear phagocyte
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0000053 PATO:0001407
[Term]
id: CL:0000779
name: multinuclear osteoclast
def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." []
synonym: "multinucleated osteoclast" EXACT []
is_a: CL:0000092 ! osteoclast
is_a: CL:0000783 ! multinucleated phagocyte
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0000053 PATO:0001908
relationship: RO:0002202 CL:0000778 ! mononuclear osteoclast
[Term]
id: CL:0000780
name: multinuclear odontoclast
def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." []
synonym: "multinucleated odontoclast" EXACT []
is_a: CL:0000588 ! odontoclast
is_a: CL:0000779 ! multinuclear osteoclast
intersection_of: CL:0000588 ! odontoclast
intersection_of: RO:0000053 PATO:0001908
relationship: RO:0002202 CL:0000781 ! mononuclear odontoclast
[Term]
id: CL:0000781
name: mononuclear odontoclast
def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." []
is_a: CL:0000588 ! odontoclast
is_a: CL:0000778 ! mononuclear osteoclast
intersection_of: CL:0000588 ! odontoclast
intersection_of: RO:0000053 PATO:0001407
[Term]
id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." []
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
synonym: "veiled cell" BROAD []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001865
intersection_of: RO:0002202 CL:0000763 ! myeloid cell
[Term]
id: CL:0000783
name: multinucleated phagocyte
def: "A phagocyte formed by the fusion of mononuclear phagocytes." []
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: RO:0000053 PATO:0001908
[Term]
id: CL:0000784
name: plasmacytoid dendritic cell
def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." []
synonym: "DC2" EXACT []
synonym: "interferon-producing cell" EXACT []
synonym: "IPC" EXACT []
synonym: "lymphoid dendritic cell" EXACT []
synonym: "pDC" EXACT []
synonym: "plasmacytoid monocyte" EXACT []
synonym: "plasmacytoid T cell" EXACT []
synonym: "T-associated plasma cell" EXACT []
synonym: "type 2 DC" EXACT []
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: RO:0002215 GO:0032606
relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell
[Term]
id: CL:0000785
name: mature B cell
def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." []
synonym: "mature B lymphocyte" EXACT []
synonym: "mature B-cell" EXACT []
synonym: "mature B-lymphocyte" EXACT []
is_a: CL:0000145 ! professional antigen presenting cell
is_a: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: RO:0002215 GO:0002504
intersection_of: RO:0002215 GO:0042113
intersection_of: RO:0002353 GO:0002335
disjoint_from: CL:0000816 ! immature B cell
disjoint_from: CL:0000817 ! precursor B cell
disjoint_from: CL:0000818 ! transitional stage B cell
relationship: RO:0002202 CL:0000818 ! transitional stage B cell
[Term]
id: CL:0000786
name: plasma cell
def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." []
synonym: "effector B cell" RELATED []
synonym: "effector B-cell" RELATED []
synonym: "plasma B cell" EXACT []
synonym: "plasma B-cell" EXACT []
synonym: "plasmacyte" EXACT []
synonym: "plasmocyte" EXACT []
is_a: CL:0000946 ! antibody secreting cell
intersection_of: CL:0000946 ! antibody secreting cell
intersection_of: BFO:0000051 CL:0017508 ! cartwheel heterochromatin
intersection_of: BFO:0000051 GO:0005794
intersection_of: lacks_plasma_membrane_part GO:0019814
intersection_of: lacks_plasma_membrane_part GO:0042613
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: RO:0002104 PR:000001935
relationship: RO:0002202 CL:0000980 ! plasmablast
[Term]
id: CL:0000787
name: memory B cell
def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." []
synonym: "memory B lymphocyte" EXACT []
synonym: "memory B-cell" EXACT []
synonym: "memory B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: lacks_plasma_membrane_part PR:000001935
intersection_of: RO:0002104 GO:0042613
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0002353 GO:0002344
[Term]
id: CL:0000788
name: naive B cell
def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." []
synonym: "naive B lymphocyte" EXACT []
synonym: "naive B-cell" EXACT []
synonym: "naive B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_not_completed GO:0002344
intersection_of: lacks_plasma_membrane_part PR:000001963
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001289
relationship: RO:0002202 CL:0000818 ! transitional stage B cell
[Term]
id: CL:0000789
name: alpha-beta T cell
def: "A T cell that expresses an alpha-beta T cell receptor complex." []
synonym: "alpha-beta T lymphocyte" EXACT []
synonym: "alpha-beta T-cell" EXACT []
synonym: "alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042105
disjoint_from: CL:0000798 ! gamma-delta T cell
[Term]
id: CL:0000790
name: immature alpha-beta T cell
def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." []
synonym: "immature alpha-beta T lymphocyte" EXACT []
synonym: "immature alpha-beta T-cell" EXACT []
synonym: "immature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 ! alpha-beta T cell
is_a: CL:0002420 ! immature T cell
intersection_of: CL:0000789 ! alpha-beta T cell
intersection_of: has_not_completed GO:0045058
[Term]
id: CL:0000791
name: mature alpha-beta T cell
def: "A alpha-beta T cell that has a mature phenotype." []
synonym: "mature alpha-beta T lymphocyte" EXACT []
synonym: "mature alpha-beta T-cell" EXACT []
synonym: "mature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 ! alpha-beta T cell
intersection_of: CL:0000789 ! alpha-beta T cell
intersection_of: RO:0002353 GO:0045058
relationship: RO:0002202 CL:0000790 ! immature alpha-beta T cell
[Term]
id: CL:0000792
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell
def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
synonym: "Treg" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0002104 PR:000001380
intersection_of: RO:0002215 GO:0050777
intersection_of: RO:0015016 PR:000001869
[Term]
id: CL:0000793
name: CD4-positive, alpha-beta intraepithelial T cell
def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." []
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0001025 UBERON:0001277
intersection_of: RO:0002215 GO:0002385
relationship: RO:0002202 CL:0000810 ! CD4-positive, alpha-beta thymocyte
[Term]
id: CL:0000794
name: CD8-positive, alpha-beta cytotoxic T cell
def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." []
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
synonym: "cytotoxic T cell" BROAD []
synonym: "cytotoxic T lymphocyte" BROAD []
synonym: "cytotoxic T-cell" BROAD []
synonym: "cytotoxic T-lymphocyte" BROAD []
synonym: "killer T cell" BROAD []
synonym: "killer T lymphocyte" BROAD []
synonym: "killer T-cell" BROAD []
synonym: "killer T-lymphocyte" BROAD []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: BFO:0000051 PR:000003466
intersection_of: BFO:0000051 PR:000003499
intersection_of: RO:0002215 GO:0001913
intersection_of: RO:0002215 GO:0033380
intersection_of: RO:0002353 GO:0030217
relationship: RO:0002202 CL:0000906 ! activated CD8-positive, alpha-beta T cell
[Term]
id: CL:0000795
name: CD8-positive, alpha-beta regulatory T cell
def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." []
synonym: "CD8+ regulatory T cell" EXACT []
synonym: "CD8+ T(reg)" EXACT []
synonym: "CD8+ Treg" EXACT []
synonym: "CD8-positive T(reg)" EXACT []
synonym: "CD8-positive Treg" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta Treg" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: RO:0002215 GO:0050777
[Term]
id: CL:0000796
name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell
def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." []
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: RO:0002104 PR:000025402
[Term]
id: CL:0000797
name: alpha-beta intraepithelial T cell
def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." []
synonym: "alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "alpha-beta intraepithelial T-cell" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000791 ! mature alpha-beta T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: RO:0001025 UBERON:0001277
intersection_of: RO:0002215 GO:0002385
[Term]
id: CL:0000798
name: gamma-delta T cell
def: "A T cell that expresses a gamma-delta T cell receptor complex." []
synonym: "gamma-delta T lymphocyte" EXACT []
synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
synonym: "gd T cell" RELATED []
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042106
[Term]
id: CL:0000799
name: immature gamma-delta T cell
def: "A gamma-delta T cell that has an immature phenotype." []
synonym: "immature gamma-delta T lymphocyte" EXACT []
synonym: "immature gamma-delta T-cell" EXACT []
synonym: "immature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
is_a: CL:0002420 ! immature T cell
intersection_of: CL:0000798 ! gamma-delta T cell
intersection_of: has_not_completed GO:0042492
intersection_of: has_not_completed GO:0045058
relationship: RO:0002202 CL:0000807 ! DN3 thymocyte
[Term]
id: CL:0000800
name: mature gamma-delta T cell
def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." []
synonym: "mature gamma-delta T lymphocyte" EXACT []
synonym: "mature gamma-delta T-cell" EXACT []
synonym: "mature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
intersection_of: CL:0000798 ! gamma-delta T cell
intersection_of: RO:0002353 GO:0045058
relationship: RO:0002202 CL:0000799 ! immature gamma-delta T cell
[Term]
id: CL:0000801
name: gamma-delta intraepithelial T cell
def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." []
synonym: "gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "gamma-delta intraepithelial T-cell" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000800 ! mature gamma-delta T cell
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: RO:0001025 UBERON:0001277
intersection_of: RO:0002215 GO:0002385
[Term]
id: CL:0000802
name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." []
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 ! gamma-delta intraepithelial T cell
intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell
intersection_of: RO:0002104 PR:000001084
[Term]
id: CL:0000803
name: CD4-negative CD8-negative gamma-delta intraepithelial T cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." []
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 ! gamma-delta intraepithelial T cell
intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
[Term]
id: CL:0000805
name: immature single positive thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." []
synonym: "immature single positive T cell" EXACT []
synonym: "immature single positive T lymphocyte" EXACT []
synonym: "immature single positive T-lymphocyte" EXACT []
synonym: "ISP" EXACT []
synonym: "T.ISP.th" EXACT []
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001307
intersection_of: lacks_plasma_membrane_part PR:000001380
intersection_of: RO:0002104 GO:0043384
intersection_of: RO:0002104 PR:000025402
intersection_of: RO:0015015 PR:000001932
relationship: RO:0002202 CL:0000808 ! DN4 thymocyte
[Term]
id: CL:0000806
name: DN2 thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." []
synonym: "DN2 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN2 alpha-beta immature T-cell" EXACT []
synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN2 cell" EXACT []
synonym: "DN2 immature T cell" EXACT []
synonym: "double negative 2" EXACT []
synonym: "preT.DN2.Th" EXACT []
synonym: "TN2 cell" EXACT []
synonym: "TN2 thymocyte" EXACT []
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000025402
intersection_of: RO:0002104 PR:000001307
intersection_of: RO:0002104 PR:000001380
relationship: RO:0002202 CL:0000894 ! DN1 thymic pro-T cell
[Term]
id: CL:0000807
name: DN3 thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." []
synonym: "DN3 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN3 alpha-beta immature T-cell" EXACT []
synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN3 cell" EXACT []
synonym: "DN3 immature T cell" EXACT []
synonym: "double negative 3" EXACT []
synonym: "early cortical thymocyte" BROAD []
synonym: "preT.DN3.Th" EXACT []
synonym: "TN3 cell" EXACT []
synonym: "TN3 thymocyte" EXACT []
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001307
intersection_of: lacks_plasma_membrane_part PR:000025402
intersection_of: RO:0002104 GO:0043384
intersection_of: RO:0002104 PR:000001380
relationship: RO:0002202 CL:0000806 ! DN2 thymocyte
[Term]
id: CL:0000808
name: DN4 thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." []
synonym: "DN4 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN4 cell" EXACT []
synonym: "DN4 immature T cell" EXACT []
synonym: "DN4 immature T-cell" EXACT []
synonym: "double negative 4" EXACT []
synonym: "early cortical thymocyte" BROAD []
synonym: "T.DN4.th" EXACT []
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001307
intersection_of: lacks_plasma_membrane_part PR:000001380
intersection_of: lacks_plasma_membrane_part PR:000025402
intersection_of: RO:0002104 GO:0043384
relationship: RO:0002202 CL:0000807 ! DN3 thymocyte
[Term]
id: CL:0000809
name: double-positive, alpha-beta thymocyte
def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." []
synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "DP cell" EXACT []
synonym: "DP thymocyte" EXACT []
synonym: "late cortical thymocyte" BROAD []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: RO:0002104 PR:000001004
intersection_of: RO:0002104 PR:000025402
relationship: RO:0002202 CL:0000805 ! immature single positive thymocyte
[Term]
id: CL:0000810
name: CD4-positive, alpha-beta thymocyte
def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." []
synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD4 cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: RO:0002104 PR:000001004
relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte
[Term]
id: CL:0000811
name: CD8-positive, alpha-beta thymocyte
def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." []
synonym: "CD8-positive, alpha-beta immature T cell" RELATED []
synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD8 cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: RO:0002104 PR:000025402
relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte
[Term]
id: CL:0000813
name: memory T cell
def: "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." []
synonym: "memory T lymphocyte" EXACT []
synonym: "memory T-cell" EXACT []
synonym: "memory T-lymphocyte" EXACT []
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: RO:0000053 PATO:0001603
intersection_of: RO:0002353 GO:0002286
intersection_of: RO:0002353 GO:0043379
disjoint_from: CL:0000898 ! naive T cell
[Term]
id: CL:0000814
name: mature NK T cell
def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." []
synonym: "mature natural killer T cell" EXACT []
synonym: "mature natural killer T lymphocyte" EXACT []
synonym: "mature natural killer T-cell" EXACT []
synonym: "mature natural killer T-lymphocyte" EXACT []
synonym: "mature NK T lymphocyte" EXACT []
synonym: "mature NK T-cell" EXACT []
synonym: "mature NK T-lymphocyte" EXACT []
synonym: "mature NKT cell" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: RO:0002104 PR:000001874
intersection_of: RO:0002215 GO:0032394
intersection_of: RO:0002215 GO:0045087
intersection_of: RO:0002353 GO:0030217
relationship: RO:0002202 CL:0002042 ! immature NK T cell stage IV
[Term]
id: CL:0000815
name: regulatory T cell
def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." []
synonym: "regulatory T lymphocyte" EXACT []
synonym: "regulatory T-cell" EXACT []
synonym: "regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
synonym: "Treg" EXACT []
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: RO:0002215 GO:0050777
[Term]
id: CL:0000816
name: immature B cell
def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." []
synonym: "immature B lymphocyte" EXACT []
synonym: "immature B-cell" EXACT []
synonym: "immature B-lymphocyte" EXACT []
synonym: "newly formed B cell" EXACT []
is_a: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: has_not_completed GO:0045190
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001289
relationship: RO:0002202 CL:0000954 ! small pre-B-II cell
[Term]
id: CL:0000817
name: precursor B cell
def: "A precursor B cell is a B cell with the phenotype CD10-positive." []
synonym: "pre-B cell" RELATED []
is_a: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: lacks_plasma_membrane_part GO:0071753
intersection_of: RO:0002104 PR:000001898
disjoint_from: CL:0000826 ! pro-B cell
[Term]
id: CL:0000818
name: transitional stage B cell
def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." []
synonym: "T1 B cell" NARROW []
synonym: "T2 B cell" NARROW []
synonym: "T3 B cell" NARROW []
synonym: "transitional B cell" EXACT []
synonym: "transitional stage B lymphocyte" EXACT []
synonym: "transitional stage B-cell" EXACT []
synonym: "transitional stage B-lymphocyte" EXACT []
is_a: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: has_not_completed GO:0002335
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0015015 PR:000001408
intersection_of: RO:0015015 PR:000001932
relationship: RO:0002202 CL:0000816 ! immature B cell
[Term]
id: CL:0000819
name: B-1 B cell
def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." []
synonym: "B-1 B lymphocyte" EXACT []
synonym: "B-1 B-cell" EXACT []
synonym: "B-1 B-lymphocyte" EXACT []
synonym: "B-1 cell" EXACT []
synonym: "B1 B cell" EXACT []
synonym: "B1 B lymphocyte" EXACT []
synonym: "B1 B-cell" EXACT []
synonym: "B1 B-lymphocyte" EXACT []
synonym: "B1 cell" EXACT []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0002104 PR:000001879
intersection_of: RO:0002215 GO:0045087
intersection_of: RO:0015015 GO:0071753
[Term]
id: CL:0000820
name: B-1a B cell
def: "A B-1 B cell that has the phenotype CD5-positive." []
synonym: "B-1a B lymphocyte" EXACT []
synonym: "B-1a B-cell" EXACT []
synonym: "B-1a B-lymphocyte" EXACT []
synonym: "B1a B cell" EXACT []
synonym: "B1a B lymphocyte" EXACT []
synonym: "B1a B-cell" EXACT []
synonym: "B1a B-lymphocyte" EXACT []
synonym: "B1a cell" EXACT []
synonym: "CD5(+) B1 cell" EXACT []
synonym: "CD5+ B1 cell" EXACT []
synonym: "CD5-positive B1 cell" EXACT []
is_a: CL:0000819 ! B-1 B cell
intersection_of: CL:0000819 ! B-1 B cell
intersection_of: RO:0002104 PR:000001839
[Term]
id: CL:0000821
name: B-1b B cell
def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." []
synonym: "B-1b B lymphocyte" EXACT []
synonym: "B-1b B-cell" EXACT []
synonym: "B-1b B-lymphocyte" EXACT []
synonym: "B1b B cell" EXACT []
synonym: "B1b B lymphocyte" EXACT []
synonym: "B1b B-cell" EXACT []
synonym: "B1b B-lymphocyte" EXACT []
synonym: "B1b cell" EXACT []
is_a: CL:0000819 ! B-1 B cell
intersection_of: CL:0000819 ! B-1 B cell
intersection_of: lacks_plasma_membrane_part PR:000001839
[Term]
id: CL:0000822
name: B-2 B cell
def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." []
synonym: "B-0 B cell" RELATED []
synonym: "B-2 B lymphocyte" EXACT []
synonym: "B-2 B-cell" EXACT []
synonym: "B-2 B-lymphocyte" EXACT []
synonym: "B2 B cell" EXACT []
synonym: "B2 B lymphocyte" EXACT []
synonym: "B2 B-cell" EXACT []
synonym: "B2 B-lymphocyte" EXACT []
synonym: "B2 cell" EXACT []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: lacks_plasma_membrane_part PR:000001879
intersection_of: RO:0002104 PR:000001289
[Term]
id: CL:0000823
name: immature natural killer cell
def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." []
synonym: "immature NK cell" EXACT []
synonym: "p-NK" RELATED []
is_a: CL:0000623 ! natural killer cell
is_a: CL:0001082 ! immature innate lymphoid cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: RO:0000053 PATO:0001501
disjoint_from: CL:0000937 ! pre-natural killer cell
relationship: RO:0002202 CL:0000937 ! pre-natural killer cell
[Term]
id: CL:0000825
name: pro-NK cell
def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." []
synonym: "natural killer cell progenitor" EXACT []
synonym: "NKP" EXACT []
synonym: "null cell" RELATED []
synonym: "preNK cell" RELATED []
synonym: "pro-natural killer cell" EXACT []
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001874
intersection_of: lacks_plasma_membrane_part PR:000002065
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001381
intersection_of: RO:0002104 PR:000001898
relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor
[Term]
id: CL:0000826
name: pro-B cell
def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." []
synonym: "pre-B cell (Philadelphia nomenclature)" RELATED []
synonym: "pre-pro B cell" BROAD []
synonym: "pro-B lymphocyte" EXACT []
synonym: "pro-B-cell" EXACT []
synonym: "pro-B-lymphocyte" EXACT []
synonym: "progenitor B cell" EXACT []
synonym: "progenitor B lymphocyte" EXACT []
synonym: "progenitor B-cell" EXACT []
synonym: "progenitor B-lymphocyte" EXACT []
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: BFO:0000051 PR:000001903
intersection_of: BFO:0000051 PR:000006611
intersection_of: RO:0000056 GO:0033152
relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor
[Term]
id: CL:0000827
name: pro-T cell
def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." []
synonym: "DN1 cell" NARROW []
synonym: "DN1 thymocyte" NARROW []
synonym: "pro-T lymphocyte" EXACT []
synonym: "progenitor T cell" EXACT []
synonym: "TN1 cell" NARROW []
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030217
relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor
[Term]
id: CL:0000828
name: thromboblast
def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." []
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: RO:0000053 PATO:0001407
intersection_of: RO:0002215 GO:0002574
relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell
[Term]
id: CL:0000829
name: basophilic myeloblast
def: "A myeloblast committed to the basophil lineage." []
is_a: CL:0000835 ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: RO:0002215 GO:0030221
relationship: RO:0002202 CL:0000613 ! basophil progenitor cell
[Term]
id: CL:0000830
name: basophilic promyelocyte
def: "A promyelocyte committed to the basophil lineage." []
is_a: CL:0000836 ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: RO:0002215 GO:0030221
relationship: RO:0002202 CL:0000829 ! basophilic myeloblast
[Term]
id: CL:0000831
name: mast cell progenitor
def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." []
synonym: "CFU-Mast" RELATED []
synonym: "CFU-MC" RELATED []
synonym: "colony forming unit mast cell" RELATED []
synonym: "MCP" EXACT []
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: BFO:0000051 PR:000007857
intersection_of: BFO:0000051 PR:000007858
intersection_of: lacks_part PR:000005307
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000001963
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: lacks_plasma_membrane_part PR:000002980
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002104 PR:000005178
intersection_of: RO:0002104 PR:000016401
intersection_of: RO:0002215 GO:0060374
intersection_of: RO:0015015 PR:000009143
intersection_of: RO:0015016 PR:000002065
intersection_of: RO:0015016 PR:000007431
relationship: RO:0002202 CL:0002028 ! basophil mast progenitor cell
[Term]
id: CL:0000832
name: eosinophilic myeloblast
def: "A myeloblast committed to the eosinophil lineage." []
is_a: CL:0000835 ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: RO:0002215 GO:0030222
relationship: RO:0002202 CL:0000611 ! eosinophil progenitor cell
[Term]
id: CL:0000833
name: eosinophilic promyelocyte
def: "A promyelocyte committed to the eosinophil lineage." []
is_a: CL:0000836 ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: RO:0002215 GO:0030222
relationship: RO:0002202 CL:0000832 ! eosinophilic myeloblast
[Term]
id: CL:0000834
name: neutrophil progenitor cell
def: "A progenitor cell of the neutrophil lineage." []
synonym: "neutrophil stem cell" RELATED []
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: RO:0002215 GO:0030223
relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell
[Term]
id: CL:0000835
name: myeloblast
def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." []
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000791
intersection_of: lacks_part GO:0042582
intersection_of: RO:0000053 PATO:0040072
relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell
[Term]
id: CL:0000836
name: promyelocyte
def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." []
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm
intersection_of: BFO:0000051 GO:0005730
intersection_of: BFO:0000051 GO:0042582
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001483
intersection_of: lacks_plasma_membrane_part PR:000001932
intersection_of: RO:0000053 PATO:0040072
intersection_of: RO:0002104 PR:000001456
intersection_of: RO:0002104 PR:000001892
relationship: RO:0002202 CL:0000835 ! myeloblast
[Term]
id: CL:0000837
name: hematopoietic multipotent progenitor cell
def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." []
synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0000053 PATO:0001402
intersection_of: RO:0002104 PR:000001003
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell
[Term]
id: CL:0000838
name: lymphoid lineage restricted progenitor cell
def: "A progenitor cell restricted to the lymphoid lineage." []
synonym: "lymphoid progenitor cell" BROAD []
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030098
disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell
[Term]
id: CL:0000839
name: myeloid lineage restricted progenitor cell
def: "A progenitor cell restricted to the myeloid lineage." []
synonym: "myeloid progenitor cell" BROAD []
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030099
[Term]
id: CL:0000840
name: immature conventional dendritic cell
def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." []
synonym: "immature myeloid dendritic cell" NARROW []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0015016 GO:0042613
intersection_of: RO:0015016 PR:000001412
intersection_of: RO:0015016 PR:000001438
relationship: RO:0002202 CL:0001029 ! common dendritic progenitor
[Term]
id: CL:0000841
name: mature conventional dendritic cell
def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." []
synonym: "mature dendritic cell" BROAD []
synonym: "mature myeloid dendritic cell" NARROW []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0002104 PR:000001310
intersection_of: RO:0015015 GO:0042613
intersection_of: RO:0015015 PR:000001412
intersection_of: RO:0015015 PR:000001438
relationship: RO:0002202 CL:0000840 ! immature conventional dendritic cell
[Term]
id: CL:0000842
name: mononuclear cell
def: "A leukocyte with a single non-segmented nucleus in the mature form." []
synonym: "mononuclear leukocyte" EXACT []
synonym: "peripheral blood mononuclear cell" NARROW []
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: RO:0000053 PATO:0001407
[Term]
id: CL:0000843
name: follicular B cell
def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." []
synonym: "Fo B cell" EXACT []
synonym: "Fo B-cell" EXACT []
synonym: "follicular B lymphocyte" EXACT []
synonym: "follicular B-cell" EXACT []
synonym: "follicular B-lymphocyte" EXACT []
is_a: CL:0000822 ! B-2 B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001879
intersection_of: lacks_plasma_membrane_part PR:000002037
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0002104 PR:000001338
[Term]
id: CL:0000844
name: germinal center B cell
def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." []
synonym: "GC B cell" EXACT []
synonym: "GC B lymphocyte" EXACT []
synonym: "GC B-cell" EXACT []
synonym: "GC B-lymphocyte" EXACT []
synonym: "germinal center B lymphocyte" EXACT []
synonym: "germinal center B-cell" EXACT []
synonym: "germinal center B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: BFO:0000050 UBERON:0001745
intersection_of: RO:0002104 PR:000001289
relationship: RO:0002202 CL:0000843 ! follicular B cell
[Term]
id: CL:0000845
name: marginal zone B cell of spleen
def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." []
synonym: "B cell of marginal zone of spleen" EXACT []
synonym: "marginal zone B cell" BROAD []
synonym: "marginal zone B lymphocyte" BROAD []
synonym: "marginal zone B-cell" BROAD []
synonym: "marginal zone B-lymphocyte" BROAD []
synonym: "marginal zone of spleen B cell" EXACT []
synonym: "MZ B cell" BROAD []
synonym: "MZ B lymphocyte" BROAD []
synonym: "MZ B-cell" BROAD []
synonym: "MZ B-lymphocyte" BROAD []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: BFO:0000050 UBERON:0001251
intersection_of: lacks_plasma_membrane_part PR:000001880
intersection_of: lacks_plasma_membrane_part PR:000002037
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0002104 PR:000001338
intersection_of: RO:0002215 GO:0042742
intersection_of: RO:0015015 GO:0071753
[Term]
id: CL:0000847
name: ciliated olfactory receptor neuron
def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." []
synonym: "ciliated olfactory sensory neuron" EXACT []
synonym: "ciliated sensory neuron" EXACT []
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000207 ! olfactory receptor cell
intersection_of: CL:0000207 ! olfactory receptor cell
intersection_of: BFO:0000051 GO:0005929
[Term]
id: CL:0000850
name: serotonergic neuron
def: "A neuron that releases serotonin as a neurotransmitter." []
synonym: "5-HT neuron" EXACT []
synonym: "5-hydroxytryptamine neuron" EXACT []
synonym: "serotinergic neuron" RELATED []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0060096
[Term]
id: CL:0000851
name: neuromast mantle cell
def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." []
is_a: CL:0000151 ! secretory cell
disjoint_from: CL:0000855 ! sensory hair cell
relationship: BFO:0000050 UBERON:0008904
[Term]
id: CL:0000852
name: neuromast supporting cell
def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." []
synonym: "neuromast support cell" EXACT []
is_a: CL:0000630 ! supporting cell
disjoint_from: CL:0000855 ! sensory hair cell
relationship: BFO:0000050 UBERON:0008904
[Term]
id: CL:0000855
name: sensory hair cell
def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." []
synonym: "hair cell" BROAD []
is_a: CL:0000199 ! mechanoreceptor cell
[Term]
id: CL:0000856
name: neuromast hair cell
def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." []
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
intersection_of: BFO:0000050 UBERON:0008904
[Term]
id: CL:0000857
name: slow muscle myoblast
def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." []
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0000189 ! slow muscle cell
[Term]
id: CL:0000860
name: classical monocyte
def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." []
synonym: "inflammatory monocyte" EXACT []
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: RO:0002215 GO:0002548
intersection_of: RO:0002215 GO:0006909
intersection_of: RO:0002215 GO:0006954
intersection_of: RO:0015015 PR:000001199
[Term]
id: CL:0000861
name: elicited macrophage
def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." []
synonym: "free macrophage" EXACT []
synonym: "wandering histiocyte" EXACT []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: RO:0000056 GO:0006954
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001813
intersection_of: RO:0002104 PR:000002064
relationship: RO:0002202 CL:0000860 ! classical monocyte
[Term]
id: CL:0000862
name: suppressor macrophage
def: "A macrophage that suppresses immune responses." []
is_a: CL:0000861 ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: RO:0002215 GO:0050777
[Term]
id: CL:0000863
name: inflammatory macrophage
def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." []
synonym: "classically activated macrophage" EXACT []
synonym: "M1 macrophage" RELATED []
is_a: CL:0000861 ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: RO:0002215 GO:0032611
intersection_of: RO:0002215 GO:0032635
intersection_of: RO:0002215 GO:0032640
intersection_of: RO:0002215 GO:0042554
intersection_of: RO:0002215 GO:0042742
intersection_of: RO:0002215 GO:0051767
[Term]
id: CL:0000864
name: tissue-resident macrophage
def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." []
synonym: "fixed macrophage" EXACT []
synonym: "resting histiocyte" EXACT []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: BFO:0000050 UBERON:0000479
[Term]
id: CL:0000866
name: thymic macrophage
def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." []
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: RO:0002215 GO:0043277
[Term]
id: CL:0000875
name: non-classical monocyte
def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." []
synonym: "patrolling monocyte" EXACT []
synonym: "resident monocyte" EXACT []
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: RO:0000053 PATO:0000587
intersection_of: RO:0002215 GO:0031294
intersection_of: RO:0002353 GO:0030224
intersection_of: RO:0015015 PR:000001206
relationship: RO:0002202 CL:0002393 ! intermediate monocyte
[Term]
id: CL:0000878
name: central nervous system macrophage
def: "A tissue-resident macrophage found in the central nervous system." []
synonym: "CNS macrophage" EXACT []
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: BFO:0000050 UBERON:0001017
[Term]
id: CL:0000889
name: myeloid suppressor cell
def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." []
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: RO:0000053 PATO:0001501
intersection_of: RO:0002104 PR:000001006
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002215 GO:0050777
[Term]
id: CL:0000891
name: foam cell
def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000892
name: smooth muscle cell derived foam cell
def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." []
is_a: CL:0000891 ! foam cell
relationship: RO:0002202 CL:0000192 ! smooth muscle cell
[Term]
id: CL:0000893
name: thymocyte
def: "An immature T cell located in the thymus." []
synonym: "immature T cell" BROAD []
synonym: "immature T lymphocyte" BROAD []
synonym: "immature T-cell" BROAD []
synonym: "immature T-lymphocyte" BROAD []
synonym: "thymic lymphocyte" EXACT []
is_a: CL:0002420 ! immature T cell
intersection_of: CL:0000084 ! T cell
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: has_not_completed GO:0045058
[Term]
id: CL:0000894
name: DN1 thymic pro-T cell
def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." []
synonym: "DN1 thymic pro-T lymphocyte" EXACT []
synonym: "DN1 thymic pro-T-cell" EXACT []
synonym: "DN1 thymic pro-T-lymphocyte" EXACT []
synonym: "DN1 thymic progenitor T cell" EXACT []
synonym: "DN1 thymocyte" EXACT []
synonym: "double negative 1" EXACT []
synonym: "preT.DN1.Th" EXACT []
is_a: CL:0000827 ! pro-T cell
intersection_of: CL:0000827 ! pro-T cell
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001380
intersection_of: RO:0002104 PR:000001307
relationship: RO:0002202 CL:0002425 ! early T lineage precursor
[Term]
id: CL:0000895
name: naive thymus-derived CD4-positive, alpha-beta T cell
def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." []
synonym: "naive CD4+ T cell" BROAD []
synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT []
synonym: "T.4Nve.Sp" EXACT []
synonym: "Th0" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001380
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001203
intersection_of: RO:0002104 PR:000001869
intersection_of: RO:0015015 PR:000001318
intersection_of: RO:0015016 PR:000001307
relationship: RO:0002202 CL:0002436 ! mature CD4 single-positive thymocyte
[Term]
id: CL:0000896
name: activated CD4-positive, alpha-beta T cell
def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." []
synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD4-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001318
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002104 PR:000001380
relationship: RO:0002202 CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell
[Term]
id: CL:0000897
name: CD4-positive, alpha-beta memory T cell
def: "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." []
synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "T4.Mem.Sp" RELATED []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0000053 PATO:0001603
intersection_of: RO:0002353 GO:0002286
intersection_of: RO:0002353 GO:0043379
[Term]
id: CL:0000898
name: naive T cell
def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." []
synonym: "naive T lymphocyte" EXACT []
synonym: "naive T-cell" EXACT []
synonym: "naive T-lymphocyte" EXACT []
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001203
intersection_of: RO:0002104 PR:000001869
intersection_of: RO:0002353 GO:0045058
intersection_of: RO:0015015 PR:000001318
intersection_of: RO:0015016 PR:000001307
[Term]
id: CL:0000899
name: T-helper 17 cell
def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." []
synonym: "helper T cell type 17" EXACT []
synonym: "IL-17-producing CD4+ T helper" EXACT []
synonym: "T helper cells type 17" EXACT []
synonym: "T(H)-17 cell" EXACT []
synonym: "Th17 CD4+ T cell" EXACT []
synonym: "Th17 cell" EXACT []
synonym: "Th17 T cell" EXACT []
synonym: "Th17 T lymphocyte" EXACT []
synonym: "Th17 T-cell" EXACT []
synonym: "Th17 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: BFO:0000051 PR:000003455
intersection_of: lacks_plasma_membrane_part PR:000001207
intersection_of: RO:0002104 PR:000001202
intersection_of: RO:0002215 GO:0032620
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
[Term]
id: CL:0000900
name: naive thymus-derived CD8-positive, alpha-beta T cell
def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." []
synonym: "naive CD8+ T cell" BROAD []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT []
synonym: "T.8Nve.Sp" NARROW []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001380
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001203
intersection_of: RO:0002104 PR:000001869
intersection_of: RO:0015015 PR:000001318
intersection_of: RO:0015016 PR:000001307
relationship: RO:0002202 CL:0002437 ! mature CD8 single-positive thymocyte
[Term]
id: CL:0000901
name: Tr1 cell
def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." []
synonym: "T-regulatory T cell type 1" EXACT []
synonym: "Tr1 T cell" EXACT []
synonym: "Tr1 T lymphocyte" EXACT []
synonym: "Tr1 T-cell" EXACT []
synonym: "Tr1 T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0002215 GO:0032613
intersection_of: RO:0002215 GO:0050777
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
[Term]
id: CL:0000906
name: activated CD8-positive, alpha-beta T cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." []
synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD8-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001203
intersection_of: lacks_plasma_membrane_part PR:000001318
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002104 PR:000001380
relationship: RO:0002202 CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell
[Term]
id: CL:0000908
name: CD8-positive, alpha-beta cytokine secreting effector T cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001318
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002104 PR:000001380
intersection_of: RO:0002215 GO:0001816
intersection_of: RO:0002353 GO:0030217
relationship: RO:0002202 CL:0000906 ! activated CD8-positive, alpha-beta T cell
[Term]
id: CL:0000909
name: CD8-positive, alpha-beta memory T cell
def: "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." []
synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "T.8Mem.Sp" RELATED []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: RO:0000053 PATO:0001603
intersection_of: RO:0002353 GO:0002286
intersection_of: RO:0002353 GO:0043379
[Term]
id: CL:0000910
name: cytotoxic T cell
def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." []
synonym: "cytotoxic T lymphocyte" EXACT []
synonym: "cytotoxic T-cell" EXACT []
synonym: "cytotoxic T-lymphocyte" EXACT []
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: RO:0002215 GO:0001913
[Term]
id: CL:0000911
name: effector T cell
def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." []
synonym: "effector T lymphocyte" EXACT []
synonym: "effector T-cell" EXACT []
synonym: "effector T-lymphocyte" EXACT []
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: RO:0000053 PATO:0045026
intersection_of: RO:0002353 GO:0030217
intersection_of: RO:0002353 GO:0045058
[Term]
id: CL:0000912
name: helper T cell
def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." []
synonym: "helper T lymphocyte" EXACT []
synonym: "helper T-cell" EXACT []
synonym: "helper T-lymphocyte" EXACT []
synonym: "T-helper cell" EXACT []
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: RO:0002215 GO:0001816
[Term]
id: CL:0000914
name: immature NK T cell
def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." []
synonym: "immature NK T lymphocyte" EXACT []
synonym: "immature NK T-cell" EXACT []
synonym: "immature NK T-lymphocyte" EXACT []
synonym: "immature NKT cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: BFO:0000051 PR:000003469
relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte
[Term]
id: CL:0000915
name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell
def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: RO:0002104 PR:000001084
relationship: RO:0002202 CL:0000811 ! CD8-positive, alpha-beta thymocyte
[Term]
id: CL:0000916
name: dendritic epidermal T cell
def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." []
synonym: "dendritic epidermal T lymphocyte" EXACT []
synonym: "dendritic epidermal T-cell" EXACT []
synonym: "dendritic epidermal T-lymphocyte" EXACT []
synonym: "DETC" EXACT []
is_a: CL:0000800 ! mature gamma-delta T cell
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: RO:0001025 UBERON:0001003
intersection_of: RO:0002215 GO:0060054
relationship: RO:0002202 CL:0002401 ! mature dendritic epithelial T cell precursor
[Term]
id: CL:0000918
name: Tc2 cell
def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." []
synonym: "CD8-positive Th2 cell" EXACT []
synonym: "T-cytotoxic T cell type 2" EXACT []
synonym: "Tc2 T cell" EXACT []
synonym: "Tc2 T lymphocyte" EXACT []
synonym: "Tc2 T-cell" EXACT []
synonym: "Tc2 T-lymphocyte" EXACT []
synonym: "Th2 CD8-positive T cell" EXACT []
synonym: "Th2 non-TFH CD8-positive T cell" EXACT []
is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell
is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell
intersection_of: BFO:0000051 PR:000001941
intersection_of: lacks_plasma_membrane_part PR:000001202
intersection_of: lacks_plasma_membrane_part PR:000001207
intersection_of: RO:0002215 GO:0032633
[Term]
id: CL:0000921
name: type I NK T cell
def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." []
synonym: "classical NK T cell" EXACT []
synonym: "invariant NK T cell" RELATED []
synonym: "type I NK T lymphocyte" EXACT []
synonym: "type I NK T-cell" EXACT []
synonym: "type I NK T-lymphocyte" EXACT []
synonym: "type I NKT cell" EXACT []
is_a: CL:0000814 ! mature NK T cell
intersection_of: CL:0000814 ! mature NK T cell
intersection_of: RO:0002215 GO:0043208
[Term]
id: CL:0000922
name: type II NK T cell
def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." []
synonym: "type II NK T lymphocyte" EXACT []
synonym: "type II NK T-cell" EXACT []
synonym: "type II NK T-lymphocyte" EXACT []
synonym: "type II NKT cell" EXACT []
is_a: CL:0000814 ! mature NK T cell
intersection_of: CL:0000814 ! mature NK T cell
intersection_of: RO:0002215 GO:0002288
[Term]
id: CL:0000923
name: CD4-positive type I NK T cell
def: "A type I NK T cell that has the phenotype CD4-positive." []
synonym: "CD4-positive type I NK T lymphocyte" EXACT []
synonym: "CD4-positive type I NK T-cell" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "CD4-positive type I NKT cell" EXACT []
synonym: "NKT.4+.SP" NARROW []
is_a: CL:0000921 ! type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: RO:0002104 PR:000001004
[Term]
id: CL:0000924
name: CD4-negative, CD8-negative type I NK T cell
def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT []
synonym: "NKT.4-.Sp" NARROW []
is_a: CL:0000921 ! type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
[Term]
id: CL:0000925
name: activated CD4-positive type I NK T cell
def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." []
synonym: "activated CD4-positive type I NK T lymphocyte" EXACT []
synonym: "activated CD4-positive type I NK T-cell" EXACT []
synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-positive type I NKT cell" EXACT []
is_a: CL:0000923 ! CD4-positive type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: RO:0002104 PR:000001004
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002215 GO:0032609
intersection_of: RO:0002215 GO:0032633
relationship: RO:0002202 CL:0000923 ! CD4-positive type I NK T cell
[Term]
id: CL:0000926
name: CD4-positive type I NK T cell secreting interferon-gamma
def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." []
synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000923 ! CD4-positive type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: RO:0002104 PR:000001004
intersection_of: RO:0002215 GO:0002827
intersection_of: RO:0002215 GO:0032609
relationship: RO:0002202 CL:0000925 ! activated CD4-positive type I NK T cell
[Term]
id: CL:0000927
name: CD4-positive type I NK T cell secreting interleukin-4
def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." []
synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000923 ! CD4-positive type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: RO:0002104 PR:000001004
intersection_of: RO:0002215 GO:0002830
intersection_of: RO:0002215 GO:0032616
intersection_of: RO:0002215 GO:0032633
relationship: RO:0002202 CL:0000925 ! activated CD4-positive type I NK T cell
[Term]
id: CL:0000928
name: activated CD4-negative, CD8-negative type I NK T cell
def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." []
synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT []
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002215 GO:0002369
relationship: RO:0002202 CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
[Term]
id: CL:0000929
name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma
def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." []
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: RO:0002215 GO:0002827
intersection_of: RO:0002215 GO:0032609
relationship: RO:0002202 CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell
[Term]
id: CL:0000930
name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4
def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." []
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: RO:0002215 GO:0002830
intersection_of: RO:0002215 GO:0032633
relationship: RO:0002202 CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell
[Term]
id: CL:0000931
name: activated type II NK T cell
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." []
synonym: "activated type II NK T lymphocyte" EXACT []
synonym: "activated type II NK T-cell" EXACT []
synonym: "activated type II NK T-lymphocyte" EXACT []
synonym: "activated type II NKT cell" EXACT []
is_a: CL:0000922 ! type II NK T cell
intersection_of: CL:0000922 ! type II NK T cell
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002215 GO:0002369
[Term]
id: CL:0000932
name: type II NK T cell secreting interferon-gamma
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." []
synonym: "type II NK T cell secreting IFN-gamma" EXACT []
synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NK T-cell secreting interferon-gamma" EXACT []
synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000922 ! type II NK T cell
intersection_of: CL:0000922 ! type II NK T cell
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002215 GO:0032609
relationship: RO:0002202 CL:0000931 ! activated type II NK T cell
[Term]
id: CL:0000933
name: type II NK T cell secreting interleukin-4
def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." []
synonym: "type II NK T cell secreting IL-4" EXACT []
synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NK T-cell secreting interleukin-4" EXACT []
synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000922 ! type II NK T cell
intersection_of: CL:0000922 ! type II NK T cell
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0002215 GO:0032633
relationship: RO:0002202 CL:0000931 ! activated type II NK T cell
[Term]
id: CL:0000934
name: CD4-positive, alpha-beta cytotoxic T cell
def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." []
synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0002215 GO:0001913
intersection_of: RO:0002353 GO:0030217
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
[Term]
id: CL:0000936
name: early lymphoid progenitor
def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." []
synonym: "ELP" RELATED []
synonym: "GMLP" RELATED []
synonym: "LMPP" RELATED []
synonym: "lymphoid-primed multipotent progenitor" EXACT []
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001460
intersection_of: RO:0002104 PR:000002001
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002104 PR:000002979
intersection_of: RO:0002215 GO:0030098
relationship: RO:0002202 CL:0002035 ! Slamf1-negative multipotent progenitor cell
[Term]
id: CL:0000937
name: pre-natural killer cell
def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." []
synonym: "pre-NK cell" EXACT []
is_a: CL:0000623 ! natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001381
intersection_of: RO:0002104 PR:000002065
[Term]
id: CL:0000940
name: mucosal invariant T cell
def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." []
synonym: "mucosal invariant T lymphocyte" EXACT []
synonym: "mucosal invariant T-cell" EXACT []
synonym: "mucosal invariant T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: RO:0002215 GO:0002227
intersection_of: RO:0002215 GO:0032394
intersection_of: RO:0002353 GO:0030217
[Term]
id: CL:0000941
name: thymic conventional dendritic cell
def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001015
intersection_of: RO:0002104 PR:000001013
relationship: RO:0002202 CL:0000894 ! DN1 thymic pro-T cell
[Term]
id: CL:0000942
name: thymic plasmacytoid dendritic cell
def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." []
is_a: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001865
relationship: RO:0002202 CL:0000894 ! DN1 thymic pro-T cell
[Term]
id: CL:0000943
name: Be1 Cell
def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." []
synonym: "B effector 1 cell" EXACT []
synonym: "B effector cell type 1" RELATED []
is_a: CL:0000968 ! Be cell
intersection_of: CL:0000968 ! Be cell
intersection_of: RO:0002215 GO:0032609
intersection_of: RO:0002215 GO:0032623
intersection_of: RO:0002215 GO:0032640
intersection_of: RO:0002215 GO:0045627
[Term]
id: CL:0000944
name: Be2 cell
def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." []
synonym: "B effector 2 cell" EXACT []
synonym: "B effector cell type 2" RELATED []
is_a: CL:0000968 ! Be cell
intersection_of: CL:0000968 ! Be cell
intersection_of: RO:0002215 GO:0032613
intersection_of: RO:0002215 GO:0032623
intersection_of: RO:0002215 GO:0032633
intersection_of: RO:0002215 GO:0032635
intersection_of: RO:0002215 GO:0045630
[Term]
id: CL:0000945
name: lymphocyte of B lineage
def: "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." []
is_a: CL:0000542 ! lymphocyte
relationship: RO:0002202 CL:0000826 ! pro-B cell
[Term]
id: CL:0000946
name: antibody secreting cell
def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." []
is_a: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: RO:0003000 GO:0042571
[Term]
id: CL:0000947
name: IgE plasma cell
def: "A long lived plasma cell that secretes IgE." []
is_a: CL:0000974 ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: RO:0003000 GO:0071743
[Term]
id: CL:0000948
name: IgE memory B cell
def: "A class switched memory B cell that expresses IgE on the cell surface." []
synonym: "IgE memory B lymphocyte" EXACT []
synonym: "IgE memory B-cell" EXACT []
synonym: "IgE memory B-lymphocyte" EXACT []
synonym: "memory IgE B cell" EXACT []
synonym: "memory IgE B lymphocyte" EXACT []
synonym: "memory IgE B-cell" EXACT []
synonym: "memory IgE B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: RO:0002104 GO:0071742
[Term]
id: CL:0000949
name: IgD plasmablast
def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." []
is_a: CL:0000980 ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: RO:0003000 GO:0071739
[Term]
id: CL:0000950
name: IgE plasmablast
def: "A plasmablast that secretes IgE." []
is_a: CL:0000980 ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: RO:0003000 GO:0071743
[Term]
id: CL:0000951
name: IgE short lived plasma cell
def: "A short lived plasma cell that secretes IgE." []
is_a: CL:0000975 ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: RO:0003000 GO:0071743
[Term]
id: CL:0000952
name: preBCR-positive large pre-B-II cell
def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." []
is_a: CL:0000957 ! large pre-B-II cell
intersection_of: CL:0000957 ! large pre-B-II cell
intersection_of: has_not_completed GO:0071708
intersection_of: RO:0002104 GO:0035369
intersection_of: RO:0002104 PR:000001858
intersection_of: RO:0002104 PR:000001859
[Term]
id: CL:0000953
name: preBCR-negative large pre-B-II cell
def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." []
is_a: CL:0000957 ! large pre-B-II cell
intersection_of: CL:0000957 ! large pre-B-II cell
intersection_of: has_not_completed GO:0071708
intersection_of: lacks_plasma_membrane_part GO:0035369
intersection_of: lacks_plasma_membrane_part PR:000001858
intersection_of: lacks_plasma_membrane_part PR:000001859
[Term]
id: CL:0000954
name: small pre-B-II cell
def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." []
synonym: "small pre-BII cell" EXACT []
is_a: CL:0000955 ! pre-B-II cell
intersection_of: CL:0000955 ! pre-B-II cell
intersection_of: BFO:0000051 PR:000003457
intersection_of: BFO:0000051 PR:000003460
intersection_of: lacks_plasma_membrane_part GO:0019815
intersection_of: lacks_plasma_membrane_part GO:0035369
intersection_of: RO:0000056 GO:0071708
[Term]
id: CL:0000955
name: pre-B-II cell
def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." []
synonym: "pre-B-lymphocyte" EXACT []
synonym: "pre-BII cell" EXACT []
is_a: CL:0000817 ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: lacks_part PR:000006611
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: RO:0002353 GO:0071707
disjoint_from: CL:0000956 ! pre-B-I cell
relationship: RO:0002202 CL:0000826 ! pro-B cell
[Term]
id: CL:0000956
name: pre-B-I cell
def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." []
synonym: "pre-BI cell" EXACT []
synonym: "pro-B cell (Philadelphia nomenclature)" RELATED []
is_a: CL:0000817 ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: BFO:0000051 PR:000003457
intersection_of: BFO:0000051 PR:000003460
intersection_of: BFO:0000051 PR:000006611
intersection_of: RO:0000056 GO:0071707
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001858
intersection_of: RO:0002104 PR:000001859
relationship: RO:0002202 CL:0000826 ! pro-B cell
[Term]
id: CL:0000957
name: large pre-B-II cell
def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." []
synonym: "large pre-B cell" BROAD []
synonym: "large pre-BII cell" EXACT []
is_a: CL:0000955 ! pre-B-II cell
intersection_of: CL:0000955 ! pre-B-II cell
intersection_of: lacks_part PR:000003457
intersection_of: lacks_part PR:000003460
intersection_of: RO:0000056 GO:0046651
[Term]
id: CL:0000958
name: T1 B cell
def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." []
synonym: "T1 B lymphocyte" EXACT []
synonym: "T1 B-cell" EXACT []
synonym: "T1 B-lymphocyte" EXACT []
synonym: "transitional stage 1 B cell" EXACT []
is_a: CL:0000818 ! transitional stage B cell
intersection_of: CL:0000818 ! transitional stage B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: lacks_plasma_membrane_part PR:000001318
intersection_of: lacks_plasma_membrane_part PR:000001338
intersection_of: lacks_plasma_membrane_part PR:000001880
intersection_of: RO:0002104 PR:000002037
[Term]
id: CL:0000959
name: T2 B cell
def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." []
synonym: "T2 B lymphocyte" EXACT []
synonym: "T2 B-cell" EXACT []
synonym: "T2 B-lymphocyte" EXACT []
synonym: "transitional stage 2 B cell" EXACT []
is_a: CL:0000818 ! transitional stage B cell
intersection_of: CL:0000818 ! transitional stage B cell
intersection_of: lacks_plasma_membrane_part PR:000001318
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001338
intersection_of: RO:0002104 PR:000001880
intersection_of: RO:0002104 PR:000002037
relationship: RO:0002202 CL:0000958 ! T1 B cell
[Term]
id: CL:0000960
name: T3 B cell
def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." []
synonym: "An1 B cell" EXACT []
synonym: "T3 B lymphocyte" EXACT []
synonym: "T3 B-cell" EXACT []
synonym: "T3 B-lymphocyte" EXACT []
synonym: "transitional stage 3 B cell" EXACT []
is_a: CL:0000818 ! transitional stage B cell
intersection_of: CL:0000818 ! transitional stage B cell
intersection_of: RO:0000056 GO:0002515
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001318
intersection_of: RO:0002104 PR:000001338
intersection_of: RO:0002104 PR:000001880
relationship: RO:0002202 CL:0000959 ! T2 B cell
[Term]
id: CL:0000961
name: Bm1 B cell
def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." []
synonym: "Bm1 B lymphocyte" EXACT []
synonym: "Bm1 B-cell" EXACT []
synonym: "Bm1 B-lymphocyte" EXACT []
is_a: CL:0000843 ! follicular B cell
is_a: CL:0002056 ! fraction F mature B cell
intersection_of: CL:0000843 ! follicular B cell
intersection_of: lacks_plasma_membrane_part PR:000001408
intersection_of: lacks_plasma_membrane_part PR:000001880
intersection_of: RO:0002104 GO:0071738
relationship: RO:0002202 CL:0000818 ! transitional stage B cell
[Term]
id: CL:0000962
name: Bm2 B cell
def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." []
synonym: "Bm2 B lymphocyte" EXACT []
synonym: "Bm2 B-cell" EXACT []
synonym: "Bm2 B-lymphocyte" EXACT []
is_a: CL:0000843 ! follicular B cell
intersection_of: CL:0000843 ! follicular B cell
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002104 PR:000001880
relationship: RO:0002202 CL:0000961 ! Bm1 B cell
[Term]
id: CL:0000963
name: Bm3-delta B cell
def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." []
synonym: "Bm3-delta B lymphocyte" EXACT []
synonym: "Bm3-delta B-cell" EXACT []
synonym: "Bm3-delta B-lymphocyte" EXACT []
is_a: CL:0000844 ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: lacks_plasma_membrane_part GO:0071753
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 PR:000001408
relationship: RO:0002202 CL:0000965 ! Bm3 B cell
[Term]
id: CL:0000964
name: Bm2' B cell
def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." []
synonym: "Bm2' B lymphocyte" EXACT []
synonym: "Bm2' B-cell" EXACT []
synonym: "Bm2-prime B cell" EXACT []
synonym: "Bm2-prime B-lymphocyte" EXACT []
synonym: "germinal center founder cell" RELATED []
is_a: CL:0000844 ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: lacks_plasma_membrane_part PR:000001880
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002215 GO:0002634
relationship: RO:0002202 CL:0000962 ! Bm2 B cell
[Term]
id: CL:0000965
name: Bm3 B cell
def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." []
synonym: "Bm3 B lymphocyte" EXACT []
synonym: "Bm3 B-cell" EXACT []
synonym: "Bm3 B-lymphocyte" EXACT []
synonym: "centroblast" RELATED []
is_a: CL:0000844 ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002104 PR:000003516
intersection_of: RO:0002215 GO:0016446
relationship: RO:0002202 CL:0000964 ! Bm2' B cell
[Term]
id: CL:0000966
name: Bm4 B cell
def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." []
synonym: "Bm4 B lymphocyte" EXACT []
synonym: "Bm4 B-cell" EXACT []
synonym: "Bm4 B-lymphocyte" EXACT []
synonym: "centrocyte" RELATED []
is_a: CL:0000844 ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: lacks_plasma_membrane_part PR:000003516
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002353 GO:0016446
relationship: RO:0002202 CL:0000963 ! Bm3-delta B cell
[Term]
id: CL:0000967
name: Bm5 B cell
def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." []
synonym: "Bm5 B lymphocyte" EXACT []
synonym: "Bm5 B-cell" EXACT []
synonym: "Bm5 B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: RO:0002353 GO:0002314
intersection_of: RO:0002353 GO:0016446
relationship: RO:0002202 CL:0000966 ! Bm4 B cell
[Term]
id: CL:0000968
name: Be cell
def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." []
synonym: "B effector cell" EXACT []
synonym: "effector B cell" EXACT []
synonym: "effector B lymphocyte" EXACT []
synonym: "effector B-cell" EXACT []
synonym: "effector B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0002215 GO:0001816
intersection_of: RO:0002215 GO:0043370
[Term]
id: CL:0000970
name: unswitched memory B cell
def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." []
synonym: "IgD+ memory B cell" BROAD []
synonym: "non-class-switched memory B cell" EXACT []
synonym: "unswitched memory B lymphocyte" EXACT []
synonym: "unswitched memory B-cell" EXACT []
synonym: "unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000787 ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071735
intersection_of: lacks_plasma_membrane_part GO:0071742
intersection_of: lacks_plasma_membrane_part GO:0071745
intersection_of: lacks_plasma_membrane_part PR:000001935
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001963
relationship: RO:0002202 CL:0000980 ! plasmablast
[Term]
id: CL:0000971
name: IgM memory B cell
def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." []
synonym: "IgM memory B lymphocyte" EXACT []
synonym: "IgM memory B-cell" EXACT []
synonym: "IgM memory B-lymphocyte" EXACT []
synonym: "memory IgM B cell" EXACT []
synonym: "memory IgM B lymphocyte" EXACT []
synonym: "memory IgM B-cell" EXACT []
synonym: "memory IgM B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: RO:0002104 GO:0071753
[Term]
id: CL:0000972
name: class switched memory B cell
def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." []
synonym: "class switched memory B lymphocyte" EXACT []
synonym: "class switched memory B-cell" EXACT []
synonym: "class switched memory B-lymphocyte" EXACT []
is_a: CL:0000787 ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071753
intersection_of: RO:0002104 PR:000001963
intersection_of: RO:0002353 GO:0045190
relationship: RO:0002202 CL:0000970 ! unswitched memory B cell
[Term]
id: CL:0000973
name: IgA memory B cell
def: "A class switched memory B cell that expresses IgA." []
synonym: "IgA memory B lymphocyte" EXACT []
synonym: "IgA memory B-cell" EXACT []
synonym: "IgA memory B-lymphocyte" EXACT []
synonym: "memory IgA B cell" EXACT []
synonym: "memory IgA B lymphocyte" EXACT []
synonym: "memory IgA B-cell" EXACT []
synonym: "memory IgA B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: RO:0002104 GO:0071745
[Term]
id: CL:0000974
name: long lived plasma cell
def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." []
is_a: CL:0000786 ! plasma cell
intersection_of: CL:0000786 ! plasma cell
intersection_of: lacks_plasma_membrane_part GO:0019814
intersection_of: lacks_plasma_membrane_part GO:0042613
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001408
intersection_of: RO:0015015 PR:000001208
intersection_of: RO:0015015 PR:000001935
intersection_of: RO:0015016 PR:000001002
relationship: RO:0002202 CL:0000975 ! short lived plasma cell
[Term]
id: CL:0000975
name: short lived plasma cell
def: "A fully differentiated plasma cell that lives for months." []
is_a: CL:0000786 ! plasma cell
intersection_of: CL:0000786 ! plasma cell
intersection_of: RO:0000053 PATO:0001604
relationship: RO:0002202 CL:0000980 ! plasmablast
[Term]
id: CL:0000976
name: IgA short lived plasma cell
def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." []
is_a: CL:0000975 ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: RO:0003000 GO:0071746
[Term]
id: CL:0000977
name: IgG short lived plasma cell
def: "A short lived plasma cell that secretes IgG." []
is_a: CL:0000975 ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: RO:0003000 GO:0071736
[Term]
id: CL:0000978
name: IgM short lived plasma cell
def: "A short lived plasma cell that secretes IgM." []
is_a: CL:0000975 ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: RO:0003000 GO:0071754
[Term]
id: CL:0000979
name: IgG memory B cell
def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." []
synonym: "IgG memory B lymphocyte" EXACT []
synonym: "IgG memory B-cell" EXACT []
synonym: "IgG memory B-lymphocyte" EXACT []
synonym: "memory IgG B cell" EXACT []
synonym: "memory IgG B lymphocyte" EXACT []
synonym: "memory IgG B-cell" EXACT []
synonym: "memory IgG B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: RO:0002104 GO:0071735
[Term]
id: CL:0000980
name: plasmablast
def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." []
synonym: "CD20-negative B cell" BROAD []
synonym: "CD27-positive, CD38-positive, CD20-negative B cell" EXACT []
is_a: CL:0000785 ! mature B cell
is_a: CL:0000946 ! antibody secreting cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001935
intersection_of: RO:0003000 GO:0042571
intersection_of: RO:0015015 PR:000001408
intersection_of: RO:0015015 PR:000001963
relationship: RO:0002202 CL:0000785 ! mature B cell
[Term]
id: CL:0000981
name: double negative memory B cell
def: "A memory B cell with the phenotype IgD-negative and CD27-negative." []
synonym: "dn memory B cell" EXACT []
synonym: "dn memory B lymphocyte" EXACT []
synonym: "dn memory B-cell" EXACT []
synonym: "dn memory B-lymphocyte" EXACT []
synonym: "double negative memory B lymphocyte" EXACT []
synonym: "double negative memory B-cell" EXACT []
synonym: "double negative memory B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: lacks_plasma_membrane_part PR:000001963
[Term]
id: CL:0000982
name: IgG plasmablast
def: "A plasmablast that secretes IgG." []
is_a: CL:0000980 ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: RO:0003000 GO:0071736
[Term]
id: CL:0000983
name: IgM plasmablast
def: "A plasmablast that secretes IgM." []
is_a: CL:0000980 ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: RO:0003000 GO:0071754
[Term]
id: CL:0000984
name: IgA plasmablast
def: "A plasmablast that secretes IgA." []
is_a: CL:0000980 ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: RO:0003000 GO:0071746
[Term]
id: CL:0000985
name: IgG plasma cell
def: "A fully differentiated plasma cell that secretes IgG." []
is_a: CL:0000974 ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: RO:0003000 GO:0071736
[Term]
id: CL:0000986
name: IgM plasma cell
def: "A fully differentiated plasma cell that secretes IgM." []
is_a: CL:0000974 ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: RO:0003000 GO:0071754
[Term]
id: CL:0000987
name: IgA plasma cell
def: "A fully differentiated plasma cell that secretes IgA." []
is_a: CL:0000974 ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: RO:0003000 GO:0071746
[Term]
id: CL:0000988
name: hematopoietic cell
def: "A cell of a hematopoietic lineage." []
synonym: "haematopoietic cell" EXACT []
synonym: "haemopoietic cell" EXACT []
synonym: "hemopoietic cell" EXACT []
is_a: CL:0000000 ! cell
[Term]
id: CL:0000989
name: CD11c-low plasmacytoid dendritic cell
def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." []
is_a: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000002978
intersection_of: RO:0015016 PR:000001013
[Term]
id: CL:0000990
name: conventional dendritic cell
def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." []
synonym: "cDC" EXACT []
synonym: "DC1" EXACT []
synonym: "dendritic reticular cell" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "type 1 DC" EXACT []
synonym: "veiled cell" BROAD []
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: RO:0015015 PR:000001013
[Term]
id: CL:0000992
name: immature CD11c-low plasmacytoid dendritic cell
def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." []
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: RO:0015016 PR:000001412
intersection_of: RO:0015016 PR:000001438
relationship: RO:0002202 CL:0001029 ! common dendritic progenitor
[Term]
id: CL:0000993
name: mature CD11c-low plasmacytoid dendritic cell
def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." []
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: RO:0002104 PR:000001310
intersection_of: RO:0015015 GO:0042613
intersection_of: RO:0015015 PR:000001412
intersection_of: RO:0015015 PR:000001438
relationship: RO:0002202 CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell
[Term]
id: CL:0000995
name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD []
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
[Term]
id: CL:0001008
name: Kit and Sca1-positive hematopoietic stem cell
def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." []
synonym: "LSK stem cell" EXACT []
synonym: "Sca1-positive hematopoietic stem cell" EXACT []
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: lacks_plasma_membrane_part PR:000001014
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001308
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000001896
intersection_of: lacks_plasma_membrane_part PR:000002977
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002104 PR:000001833
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002104 PR:000002979
disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
[Term]
id: CL:0001012
name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0000557 ! granulocyte monocyte progenitor cell
union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell
[Term]
id: CL:0001019
name: CD115-positive monocyte OR common dendritic progenitor
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
union_of: CL:0001022 ! CD115-positive monocyte
union_of: CL:0001029 ! common dendritic progenitor
[Term]
id: CL:0001021
name: CD34-positive, CD38-positive common lymphoid progenitor
def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." []
synonym: "CD10-positive common lymphocyte precursor" EXACT []
synonym: "CD10-positive common lymphocyte progenitor" EXACT []
synonym: "CD10-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002104 PR:000001898
disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor
relationship: RO:0002202 CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
[Term]
id: CL:0001022
name: CD115-positive monocyte
def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." []
is_a: CL:0000576 ! monocyte
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0000576 ! monocyte
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000002062
relationship: RO:0002202 CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor
[Term]
id: CL:0001023
name: Kit-positive, CD34-positive common myeloid progenitor
def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." []
synonym: "CD117-positive common myeloid precursor" BROAD []
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
is_a: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0015016 GO:0033001
intersection_of: RO:0015016 PR:000001481
disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
relationship: RO:0002202 CL:0002035 ! Slamf1-negative multipotent progenitor cell
[Term]
id: CL:0001024
name: CD34-positive, CD38-negative hematopoietic stem cell
def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." []
synonym: "CD133-positive hematopoietic stem cell" EXACT []
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001408
intersection_of: lacks_plasma_membrane_part PR:000001483
intersection_of: lacks_plasma_membrane_part PR:000001892
intersection_of: lacks_plasma_membrane_part PR:000001945
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001786
intersection_of: RO:0002104 PR:000001809
intersection_of: RO:0002104 PR:000001843
[Term]
id: CL:0001025
name: Kit-positive, Sca1-positive common lymphoid progenitor
def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." []
synonym: "CD217-positive common lymphocyte precursor" EXACT []
synonym: "CD217-positive common lymphocyte progenitor" EXACT []
synonym: "CD217-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: lacks_plasma_membrane_part PR:000001014
intersection_of: RO:0002104 PR:000001869
intersection_of: RO:0002104 PR:000001963
intersection_of: RO:0002104 PR:000002001
intersection_of: RO:0002104 PR:000002037
intersection_of: RO:0015016 PR:000002065
intersection_of: RO:0015016 PR:000002979
relationship: RO:0002202 CL:0000936 ! early lymphoid progenitor
[Term]
id: CL:0001026
name: CD34-positive, CD38-positive common myeloid progenitor
def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." []
synonym: "CD71-positive common myeloid precursor" NARROW []
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
is_a: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: lacks_plasma_membrane_part PR:000001015
intersection_of: lacks_plasma_membrane_part PR:000001836
intersection_of: lacks_plasma_membrane_part PR:000001867
intersection_of: lacks_plasma_membrane_part PR:000001898
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0015016 PR:000001865
relationship: RO:0002202 CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
[Term]
id: CL:0001027
name: CD7-negative lymphoid progenitor cell
def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." []
synonym: "CD7-negative lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: lacks_plasma_membrane_part PR:000001015
intersection_of: lacks_plasma_membrane_part PR:000001836
intersection_of: RO:0002104 PR:000001003
relationship: RO:0002202 CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
[Term]
id: CL:0001028
name: CD7-positive lymphoid progenitor cell
def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." []
synonym: "CD7-positive lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: lacks_plasma_membrane_part PR:000001015
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001836
relationship: RO:0002202 CL:0001027 ! CD7-negative lymphoid progenitor cell
[Term]
id: CL:0001029
name: common dendritic progenitor
def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." []
synonym: "CDP" EXACT []
synonym: "common dendritic precursor" EXACT []
synonym: "pro-DCs" EXACT []
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002104 PR:000002001
intersection_of: RO:0002104 PR:000002062
intersection_of: RO:0015016 PR:000002065
relationship: RO:0002202 CL:0002009 ! macrophage dendritic cell progenitor
[Term]
id: CL:0001030
name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor
[Term]
id: CL:0001031
name: cerebellar granule cell
def: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." []
synonym: "granule cell of the cerebellum" EXACT []
is_a: CL:0000120 ! granule cell
is_a: CL:2000028 ! cerebellum glutamatergic neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0002037
relationship: RO:0002207 CL:0002362 ! cerebellar granule cell precursor
[Term]
id: CL:0001032
name: cortical granule cell
def: "Granule cell that is part of the cerebral cortex." []
is_a: CL:0000120 ! granule cell
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0000956
[Term]
id: CL:0001033
name: hippocampal granule cell
def: "Granule cell with a soma found in the hippocampus." []
is_a: CL:0000120 ! granule cell
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0002421
[Term]
id: CL:0001035
name: bone cell
def: "A connective tissue cell found in bone." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001474
[Term]
id: CL:0001041
name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell
def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." []
synonym: "CD8+CXCR3+ T cell" EXACT []
synonym: "CD8+CXCR3+ T lymphocyte" EXACT []
synonym: "CD8+CXCR3+ T(reg)" EXACT []
synonym: "CD8+CXCR3+ T-cell" EXACT []
synonym: "CD8+CXCR3+ Treg" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT []
synonym: "CD8-positive, CXCR3-positive, Treg" EXACT []
is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
intersection_of: BFO:0000051 PR:000001207
intersection_of: RO:0002215 GO:0032613
intersection_of: RO:0002215 GO:0032689
intersection_of: RO:0002215 GO:0042130
[Term]
id: CL:0001042
name: T-helper 22 cell
def: "CD4-positive, alpha-beta T cell that produces IL-22." []
synonym: "helper T cell type 22" EXACT []
synonym: "T(H)-22 cell" EXACT []
synonym: "Th22 cell" EXACT []
synonym: "Th22 T cell" EXACT []
synonym: "Th22 T lymphocyte" EXACT []
synonym: "Th22 T-cell" EXACT []
synonym: "Th22 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: RO:0002215 GO:0032626
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
[Term]
id: CL:0001044
name: effector CD4-positive, alpha-beta T cell
def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." []
synonym: "effector CD4+ T cell" BROAD []
synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector CD4-positive, alpha-beta T-cell" EXACT []
synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: lacks_plasma_membrane_part PR:000001203
intersection_of: lacks_plasma_membrane_part PR:000025402
intersection_of: RO:0002104 GO:0042105
intersection_of: RO:0002104 PR:000001004
intersection_of: RO:0002104 PR:000001015
[Term]
id: CL:0001050
name: effector CD8-positive, alpha-beta T cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." []
synonym: "effector CD8+ T cell" BROAD []
synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector CD8-positive, alpha-beta T-cell" EXACT []
synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001203
intersection_of: RO:0002104 GO:0042105
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000025402
[Term]
id: CL:0001051
name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." []
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT []
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT []
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT []
synonym: "non-Th1/Th17 CD4+ T cell" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001202
intersection_of: lacks_plasma_membrane_part PR:000001207
[Term]
id: CL:0001052
name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." []
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT []
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT []
synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001202
intersection_of: lacks_plasma_membrane_part PR:000001207
[Term]
id: CL:0001053
name: IgD-negative memory B cell
def: "A memory B cell that lacks expression of surface IgD." []
synonym: "IgD- memory B cell" EXACT []
is_a: CL:0000787 ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
[Term]
id: CL:0001054
name: CD14-positive monocyte
def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." []
synonym: "monocyte" NARROW []
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: RO:0002104 PR:000001889
[Term]
id: CL:0001055
name: CD14-positive, CD16-low monocyte
def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." []
synonym: "intermediate monocyte, human" EXACT []
is_a: CL:0001054 ! CD14-positive monocyte
is_a: CL:0002393 ! intermediate monocyte
intersection_of: CL:0002393 ! intermediate monocyte
intersection_of: RO:0002104 PR:000001889
intersection_of: RO:0015016 PR:000001483
[Term]
id: CL:0001059
name: common myeloid progenitor, CD34-positive
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." []
synonym: "CFU-GEMM" RELATED []
synonym: "CFU-S" RELATED []
synonym: "CMP" RELATED []
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED []
synonym: "common myeloid precursor, CD34-positive" EXACT []
synonym: "multipotential myeloid stem cell" RELATED []
synonym: "myeloid stem cell" RELATED []
synonym: "pluripotent stem cell (bone marrow)" RELATED []
is_a: CL:0000049 ! common myeloid progenitor
intersection_of: CL:0000049 ! common myeloid progenitor
intersection_of: BFO:0000051 PR:000001944
intersection_of: BFO:0000051 PR:000005307
intersection_of: BFO:0000051 PR:000007857
intersection_of: BFO:0000051 PR:000007858
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002215 GO:0002573
intersection_of: RO:0002215 GO:0043011
[Term]
id: CL:0001060
name: hematopoietic oligopotent progenitor cell, lineage-negative
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0000053 PATO:0001401
relationship: RO:0002202 CL:0000837 ! hematopoietic multipotent progenitor cell
[Term]
id: CL:0001065
name: innate lymphoid cell
def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: RO:0002215 GO:0001816
intersection_of: RO:0002215 GO:0045087
[Term]
id: CL:0001066
name: erythroid progenitor cell, mammalian
def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." []
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
is_a: CL:0000038 ! erythroid progenitor cell
intersection_of: CL:0000038 ! erythroid progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: RO:0002104 PR:000001945
intersection_of: RO:0002215 GO:0030218
[Term]
id: CL:0001067
name: group 1 innate lymphoid cell
def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: RO:0002215 GO:0032609
[Term]
id: CL:0001069
name: group 2 innate lymphoid cell
def: "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." []
synonym: "ILC2" EXACT []
synonym: "natural helper cell" EXACT []
synonym: "nuocyte" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: RO:0002215 GO:0032634
[Term]
id: CL:0001071
name: group 3 innate lymphoid cell
def: "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." []
synonym: "ILC3" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: BFO:0000051 PR:000003455
[Term]
id: CL:0001082
name: immature innate lymphoid cell
def: "An innate lyphoid cell with an immature phenotype." []
synonym: "immature ILC" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: RO:0000053 PATO:0001501
[Term]
id: CL:0001200
name: lymphocyte of B lineage, CD19-positive
def: "A lymphocyte of B lineage that is CD19-positive." []
is_a: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: RO:0002104 PR:000001002
intersection_of: RO:0002162 NCBITaxon:40674
[Term]
id: CL:0001201
name: B cell, CD19-positive
def: "A B cell that is CD19-positive." []
synonym: "B lymphocyte, CD19-positive" EXACT []
synonym: "B-cell, CD19-positive" EXACT []
synonym: "B-lymphocyte, CD19-positive" EXACT []
synonym: "CD19+ B cell" EXACT []
synonym: "CD19-positive B cell" EXACT []
is_a: CL:0000236 ! B cell
is_a: CL:0001200 ! lymphocyte of B lineage, CD19-positive
intersection_of: CL:0001200 ! lymphocyte of B lineage, CD19-positive
intersection_of: RO:0002104 PR:000001002
intersection_of: RO:0002162 NCBITaxon:40674
intersection_of: RO:0002215 GO:0019724
[Term]
id: CL:0001202
name: CD86-positive plasmablast
def: "A plasmablast that is CD86-positive." []
synonym: "CD86+ plasmablast" EXACT []
synonym: "CD86-positive, CD20-negative plasmablast" BROAD []
is_a: CL:0000980 ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: RO:0002104 PR:000001412
[Term]
id: CL:0001658
name: visual pigment cell (sensu Nematoda and Protostomia)
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0002000
name: Kit-positive erythroid progenitor cell
def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." []
synonym: "c- Kit-positive erythroid progenitor cell" EXACT []
is_a: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: lacks_plasma_membrane_part GO:0033001
intersection_of: lacks_plasma_membrane_part PR:000001833
intersection_of: lacks_plasma_membrane_part PR:000001865
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: lacks_plasma_membrane_part PR:000009127
intersection_of: RO:0002104 PR:000001345
intersection_of: RO:0002104 PR:000002065
relationship: RO:0002202 CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
[Term]
id: CL:0002001
name: CD34-positive, CD38-positive granulocyte monocyte progenitor
def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." []
is_a: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002104 PR:000001865
relationship: RO:0002202 CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
[Term]
id: CL:0002002
name: Kit-positive granulocyte monocyte progenitor
def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." []
is_a: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001206
intersection_of: lacks_plasma_membrane_part PR:000001843
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0015015 GO:0033001
intersection_of: RO:0015015 PR:000001479
relationship: RO:0002202 CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
[Term]
id: CL:0002003
name: CD34-positive, GlyA-negative erythroid progenitor cell
def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." []
is_a: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: lacks_plasma_membrane_part PR:000001460
intersection_of: RO:0002104 PR:000001003
relationship: RO:0002202 CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
[Term]
id: CL:0002004
name: CD34-negative, GlyA-negative proerythroblast
def: "A proerythoblast that is CD34-negative and GlyA-negative." []
is_a: CL:0000547 ! proerythroblast
intersection_of: CL:0000547 ! proerythroblast
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: lacks_plasma_membrane_part PR:000001460
relationship: RO:0002202 CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell
[Term]
id: CL:0002005
name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." []
is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001015
intersection_of: lacks_plasma_membrane_part PR:000001865
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001408
[Term]
id: CL:0002006
name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." []
is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: lacks_plasma_membrane_part PR:000001479
intersection_of: lacks_plasma_membrane_part PR:000001843
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0015016 GO:0033001
[Term]
id: CL:0002007
name: Kit-low, CD34-positive eosinophil progenitor cell
def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." []
is_a: CL:0000611 ! eosinophil progenitor cell
intersection_of: CL:0000611 ! eosinophil progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001867
intersection_of: RO:0015016 PR:000002065
relationship: RO:0002202 CL:0002002 ! Kit-positive granulocyte monocyte progenitor
[Term]
id: CL:0002008
name: CD34-positive, CD38-positive eosinophil progenitor cell
def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." []
is_a: CL:0000611 ! eosinophil progenitor cell
intersection_of: CL:0000611 ! eosinophil progenitor cell
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001408
intersection_of: RO:0002104 PR:000001865
relationship: RO:0002202 CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor
[Term]
id: CL:0002009
name: macrophage dendritic cell progenitor
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." []
synonym: "MDP" EXACT []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: RO:0002215 GO:0030224
intersection_of: RO:0002215 GO:0043011
relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell
[Term]
id: CL:0002010
name: pre-conventional dendritic cell
def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." []
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: lacks_plasma_membrane_part GO:0042613
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: lacks_plasma_membrane_part PR:000001083
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001289
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001889
intersection_of: lacks_plasma_membrane_part PR:000002978
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002104 PR:000001013
intersection_of: RO:0002104 PR:000001968
intersection_of: RO:0002104 PR:000002001
relationship: RO:0002202 CL:0001029 ! common dendritic progenitor
[Term]
id: CL:0002011
name: Kit-positive macrophage dendritic cell progenitor
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." []
synonym: "murine MDP" EXACT []
is_a: CL:0002009 ! macrophage dendritic cell progenitor
intersection_of: CL:0002009 ! macrophage dendritic cell progenitor
intersection_of: RO:0002104 PR:000001206
intersection_of: RO:0002104 PR:000002001
intersection_of: RO:0002104 PR:000002062
intersection_of: RO:0015015 PR:000002065
relationship: RO:0002202 CL:0002002 ! Kit-positive granulocyte monocyte progenitor
[Term]
id: CL:0002012
name: Kit-low proerythroblast
def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." []
is_a: CL:0000547 ! proerythroblast
intersection_of: CL:0000547 ! proerythroblast
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000002981
intersection_of: RO:0015015 PR:000001945
intersection_of: RO:0015016 PR:000002065
relationship: RO:0002202 CL:0002000 ! Kit-positive erythroid progenitor cell
[Term]
id: CL:0002013
name: GlyA-positive basophilic erythroblast
def: "A basophilic erythroblast that is GlyA-positive." []
is_a: CL:0000549 ! basophilic erythroblast
intersection_of: CL:0000549 ! basophilic erythroblast
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: RO:0002104 PR:000001460
relationship: RO:0002202 CL:0002004 ! CD34-negative, GlyA-negative proerythroblast
[Term]
id: CL:0002014
name: Kit-negative, Ly-76 high basophilic erythroblast
def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." []
is_a: CL:0000549 ! basophilic erythroblast
intersection_of: CL:0000549 ! basophilic erythroblast
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002065
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0015015 PR:000002981
relationship: RO:0002202 CL:0002012 ! Kit-low proerythroblast
[Term]
id: CL:0002015
name: Kit-negative, Ly-76 high polychromatophilic erythroblast
def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." []
synonym: "late basophilic and polychromatophilic erythroblast" BROAD []
is_a: CL:0000550 ! polychromatophilic erythroblast
intersection_of: CL:0000550 ! polychromatophilic erythroblast
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002065
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0015015 PR:000002981
relationship: RO:0002202 CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast
[Term]
id: CL:0002016
name: CD71-low, GlyA-positive polychromatic erythroblast
def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." []
is_a: CL:0000550 ! polychromatophilic erythroblast
intersection_of: CL:0000550 ! polychromatophilic erythroblast
intersection_of: RO:0002104 PR:000001460
intersection_of: RO:0015016 PR:000001945
relationship: RO:0002202 CL:0002013 ! GlyA-positive basophilic erythroblast
[Term]
id: CL:0002017
name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts
def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." []
is_a: CL:0000552 ! orthochromatic erythroblast
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002065
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0015015 PR:000002981
intersection_of: RO:0015016 PR:000001945
relationship: RO:0002202 CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast
[Term]
id: CL:0002018
name: CD71-negative, GlyA-positive orthochromatic erythroblast
def: "An erythroblast that is GlyA-positive and CD71-negative." []
is_a: CL:0000552 ! orthochromatic erythroblast
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: lacks_plasma_membrane_part PR:000001945
intersection_of: RO:0002104 PR:000001460
relationship: RO:0002202 CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast
[Term]
id: CL:0002019
name: Ly-76 high reticulocyte
def: "A reticulocyte that is Ly76-high and is Kit-negative." []
is_a: CL:0002422 ! enucleated reticulocyte
intersection_of: CL:0002422 ! enucleated reticulocyte
intersection_of: RO:0015015 PR:000002981
relationship: RO:0002202 CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts
[Term]
id: CL:0002020
name: GlyA-positive reticulocytes
def: "A reticulocyte that is GlyA-positive." []
is_a: CL:0002422 ! enucleated reticulocyte
intersection_of: CL:0002422 ! enucleated reticulocyte
intersection_of: RO:0002104 PR:000001460
relationship: RO:0002202 CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast
[Term]
id: CL:0002021
name: GlyA-positive erythrocyte
def: "An enucleate erythrocyte that is GlyA-positive." []
is_a: CL:0000595 ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: RO:0002104 PR:000001460
relationship: RO:0002202 CL:0002020 ! GlyA-positive reticulocytes
[Term]
id: CL:0002022
name: Ly-76 high positive erythrocyte
def: "An enucleate erythrocyte that is Lyg-76-high." []
is_a: CL:0000595 ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: RO:0015015 PR:000002981
relationship: RO:0002202 CL:0002019 ! Ly-76 high reticulocyte
[Term]
id: CL:0002024
name: Kit-positive megakaryocyte progenitor cell
def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." []
is_a: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001833
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002104 PR:000005178
intersection_of: RO:0015016 PR:000001479
intersection_of: RO:0015016 PR:000001483
relationship: RO:0002202 CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
[Term]
id: CL:0002027
name: CD9-positive, CD41-positive megakaryocyte cell
def: "A megakaryocyte cell with is CD9-positive and CD41-positive." []
is_a: CL:0000556 ! megakaryocyte
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: RO:0002104 PR:000005178
intersection_of: RO:0002104 PR:000009127
relationship: RO:0002202 CL:0002024 ! Kit-positive megakaryocyte progenitor cell
[Term]
id: CL:0002028
name: basophil mast progenitor cell
def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" []
synonym: "BMCP" EXACT []
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: BFO:0000051 PR:000005307
intersection_of: BFO:0000051 PR:000007857
intersection_of: BFO:0000051 PR:000007858
intersection_of: lacks_plasma_membrane_part PR:000007431
intersection_of: lacks_plasma_membrane_part PR:000016401
intersection_of: RO:0002104 PR:000001867
intersection_of: RO:0002215 GO:0030221
intersection_of: RO:0002215 GO:0060374
relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell
[Term]
id: CL:0002029
name: Fc-epsilon RIalpha-low mast cell progenitor
def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." []
is_a: CL:0000831 ! mast cell progenitor
intersection_of: CL:0000831 ! mast cell progenitor
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000001006
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002104 PR:000009143
intersection_of: RO:0015016 PR:000007431
relationship: RO:0002202 CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell
[Term]
id: CL:0002030
name: Fc-epsilon RIalpha-high basophil progenitor cell
def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." []
is_a: CL:0000613 ! basophil progenitor cell
intersection_of: CL:0000613 ! basophil progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000002065
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0015015 PR:000007431
relationship: RO:0002202 CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell
[Term]
id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." []
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001400
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: RO:0002202 CL:0002032 ! hematopoietic oligopotent progenitor cell
[Term]
id: CL:0002032
name: hematopoietic oligopotent progenitor cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." []
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001401
relationship: RO:0002202 CL:0000837 ! hematopoietic multipotent progenitor cell
[Term]
id: CL:0002033
name: short term hematopoietic stem cell
def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." []
synonym: "ST stem cell" EXACT []
synonym: "ST-HSC" EXACT []
is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: lacks_plasma_membrane_part PR:000002001
intersection_of: RO:0002104 PR:000001003
intersection_of: RO:0002104 PR:000001833
relationship: RO:0002202 CL:0002034 ! long term hematopoietic stem cell
[Term]
id: CL:0002034
name: long term hematopoietic stem cell
def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." []
synonym: "LT stem cell" EXACT []
synonym: "LT-HSC" EXACT []
is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: lacks_plasma_membrane_part PR:000002001
intersection_of: RO:0002104 PR:000001833
intersection_of: RO:0015016 PR:000001843
[Term]
id: CL:0002035
name: Slamf1-negative multipotent progenitor cell
def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." []
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001833
intersection_of: lacks_plasma_membrane_part PR:000002001
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002104 PR:000002979
relationship: RO:0002202 CL:0002036 ! Slamf1-positive multipotent progenitor cell
[Term]
id: CL:0002036
name: Slamf1-positive multipotent progenitor cell
def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." []
synonym: "KSL cell" EXACT []
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: RO:0002104 PR:000001833
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002104 PR:000002979
disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: RO:0002202 CL:0002033 ! short term hematopoietic stem cell
[Term]
id: CL:0002037
name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell
def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." []
synonym: "memory alpha beta IEL" EXACT []
is_a: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell
intersection_of: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell
intersection_of: RO:0002104 PR:000001083
intersection_of: RO:0002104 PR:000001307
intersection_of: RO:0002104 PR:000001839
[Term]
id: CL:0002038
name: T follicular helper cell
def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." []
synonym: "follicular B helper T cell" RELATED []
synonym: "follicular helper T cell" RELATED []
synonym: "follicular helper T-cell" RELATED []
synonym: "follicular T cell" RELATED []
synonym: "follicular T-cell" RELATED []
synonym: "follicular T-helper cell" RELATED []
synonym: "T(FH)" EXACT []
synonym: "Tfh" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: BFO:0000051 PR:000003450
intersection_of: lacks_plasma_membrane_part PR:000001203
intersection_of: RO:0002104 PR:000001209
intersection_of: RO:0002104 PR:000001860
intersection_of: RO:0002104 PR:000001919
intersection_of: RO:0002215 GO:0045830
intersection_of: RO:0002215 GO:0051024
relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell
[Term]
id: CL:0002039
name: immature NK T cell stage I
def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." []
is_a: CL:0000914 ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001307
intersection_of: lacks_plasma_membrane_part PR:000001874
intersection_of: RO:0015015 PR:000001932
intersection_of: RO:0015016 PR:000001004
intersection_of: RO:0015016 PR:000025402
relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte
[Term]
id: CL:0002040
name: immature NK T cell stage II
def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." []
synonym: "NKT.44-NK1.1-.Th" EXACT []
is_a: CL:0000914 ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001307
intersection_of: lacks_plasma_membrane_part PR:000001874
intersection_of: RO:0015016 PR:000001932
relationship: RO:0002202 CL:0002039 ! immature NK T cell stage I
[Term]
id: CL:0002041
name: immature NK T cell stage III
def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." []
synonym: "NKT.44+.NK1.1-.Th" BROAD []
is_a: CL:0000914 ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001874
intersection_of: RO:0002104 PR:000001307
intersection_of: RO:0015016 PR:000001008
intersection_of: RO:0015016 PR:000001932
relationship: RO:0002202 CL:0002040 ! immature NK T cell stage II
[Term]
id: CL:0002042
name: immature NK T cell stage IV
def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." []
synonym: "NKT.44+.NK1.1-.Th" BROAD []
is_a: CL:0000914 ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001874
intersection_of: RO:0002104 PR:000001307
intersection_of: RO:0015015 PR:000001008
intersection_of: RO:0015016 PR:000001932
relationship: RO:0002202 CL:0002041 ! immature NK T cell stage III
[Term]
id: CL:0002043
name: CD34-positive, CD38-negative multipotent progenitor cell
def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." []
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000001015
intersection_of: lacks_plasma_membrane_part PR:000001408
intersection_of: lacks_plasma_membrane_part PR:000001843
intersection_of: RO:0002104 PR:000001003
relationship: RO:0002202 CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
[Term]
id: CL:0002044
name: Kit-positive, integrin beta7-high basophil mast progenitor cell
def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." []
is_a: CL:0002028 ! basophil mast progenitor cell
intersection_of: CL:0002028 ! basophil mast progenitor cell
intersection_of: lacks_plasma_membrane_part PR:000002065
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000001479
intersection_of: RO:0002104 PR:000001483
intersection_of: RO:0015015 PR:000009143
[Term]
id: CL:0002045
name: fraction A pre-pro B cell
def: "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." []
synonym: "fraction A" BROAD []
synonym: "pre pro B cell" RELATED []
is_a: CL:0000826 ! pro-B cell
intersection_of: CL:0000826 ! pro-B cell
intersection_of: lacks_plasma_membrane_part PR:000002039
intersection_of: lacks_plasma_membrane_part PR:000002980
intersection_of: RO:0002104 PR:000001015
intersection_of: RO:0002104 PR:000001879
intersection_of: RO:0002104 PR:000002037
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0015016 PR:000001932
[Term]
id: CL:0002047
name: fraction B precursor B cell
def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." []
synonym: "Fr. B" BROAD []
synonym: "Fraction B" BROAD []
is_a: CL:0002400 ! fraction B/C precursor B cell
intersection_of: CL:0002400 ! fraction B/C precursor B cell
intersection_of: lacks_plasma_membrane_part PR:000002039
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001932
relationship: RO:0002202 CL:0002045 ! fraction A pre-pro B cell
[Term]
id: CL:0002049
name: fraction C precursor B cell
def: "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." []
synonym: "Fraction C" RELATED []
is_a: CL:0002400 ! fraction B/C precursor B cell
intersection_of: CL:0002400 ! fraction B/C precursor B cell
intersection_of: BFO:0000051 PR:000001858
intersection_of: BFO:0000051 PR:000001859
intersection_of: has_not_completed GO:0071707
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002039
intersection_of: RO:0002104 PR:000003457
intersection_of: RO:0002104 PR:000003460
relationship: RO:0002202 CL:0002047 ! fraction B precursor B cell
[Term]
id: CL:0002050
name: fraction C' precursor B cell
def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." []
synonym: "Fr. C'" BROAD []
synonym: "Fraction C-prime" BROAD []
is_a: CL:0000817 ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: RO:0002104 GO:0035369
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001380
intersection_of: RO:0002104 PR:000001879
intersection_of: RO:0002104 PR:000002039
intersection_of: RO:0015015 PR:000001932
relationship: RO:0002202 CL:0002049 ! fraction C precursor B cell
[Term]
id: CL:0002052
name: fraction D precursor B cell
def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." []
synonym: "Fr. D" BROAD []
synonym: "fraction D pre-B cell" EXACT []
is_a: CL:0000817 ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_not_completed GO:0071708
intersection_of: lacks_plasma_membrane_part GO:0035369
intersection_of: RO:0002104 PR:000001002
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001380
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002037
intersection_of: RO:0002104 PR:000002039
intersection_of: RO:0015016 PR:000001879
relationship: RO:0002202 CL:0002050 ! fraction C' precursor B cell
[Term]
id: CL:0002054
name: fraction E immature B cell
def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." []
is_a: CL:0000816 ! immature B cell
intersection_of: CL:0000816 ! immature B cell
intersection_of: lacks_plasma_membrane_part PR:000001380
intersection_of: lacks_plasma_membrane_part PR:000001869
intersection_of: RO:0002104 PR:000001002
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002037
intersection_of: RO:0015016 PR:000001879
relationship: RO:0002202 CL:0002052 ! fraction D precursor B cell
[Term]
id: CL:0002056
name: fraction F mature B cell
def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." []
is_a: CL:0000822 ! B-2 B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: lacks_plasma_membrane_part PR:000001879
intersection_of: lacks_plasma_membrane_part PR:000001880
intersection_of: lacks_plasma_membrane_part PR:000002037
intersection_of: RO:0002104 GO:0071738
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0002104 PR:000001338
relationship: RO:0002202 CL:0002054 ! fraction E immature B cell
[Term]
id: CL:0002058
name: Gr1-low non-classical monocyte
def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." []
is_a: CL:0000875 ! non-classical monocyte
is_a: CL:0001022 ! CD115-positive monocyte
intersection_of: CL:0000875 ! non-classical monocyte
intersection_of: lacks_plasma_membrane_part PR:000001014
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001206
intersection_of: RO:0002104 PR:000001879
intersection_of: RO:0002104 PR:000002062
intersection_of: RO:0015016 PR:000001199
intersection_of: RO:0015016 PR:000002980
relationship: RO:0002202 CL:0002398 ! Gr1-positive, CD43-positive monocyte
[Term]
id: CL:0002059
name: CD8alpha-positive thymic conventional dendritic cell
def: "A conventional thymic dendritic cell that is CD8alpha-positive." []
synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT []
synonym: "DC.8+.Th" EXACT []
is_a: CL:0000941 ! thymic conventional dendritic cell
intersection_of: CL:0000941 ! thymic conventional dendritic cell
intersection_of: RO:0002104 PR:000001084
[Term]
id: CL:0002062
name: type I pneumocyte
def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." []
synonym: "AT1" EXACT []
synonym: "ATI" EXACT []
synonym: "lung type 1 cells" EXACT []
synonym: "membranous pneumocytes" EXACT []
synonym: "pulmonary alveolar type I cell" EXACT []
synonym: "small alveolar cells" EXACT []
synonym: "squamous alveolar cell" EXACT []
synonym: "squamous alveolar lining cell" EXACT []
synonym: "type 1 alveolar epithelial cells" EXACT []
synonym: "type 1 pneumocyte" EXACT []
synonym: "type I alveolar cells" EXACT []
synonym: "type I alveolar epithelial cells" EXACT []
is_a: CL:0000322 ! pneumocyte
intersection_of: CL:0000322 ! pneumocyte
intersection_of: RO:0002215 GO:0007585
[Term]
id: CL:0002063
name: type II pneumocyte
def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." []
synonym: "AT2" EXACT []
synonym: "ATII" EXACT []
synonym: "cuboidal type II cell" EXACT []
synonym: "granular pneumocyte" EXACT []
synonym: "great alveolar cell" EXACT []
synonym: "lung type 2 cell" EXACT []
synonym: "lung type II cell" RELATED []
synonym: "TII" EXACT []
synonym: "type 2 alveolar epithelial cell" EXACT []
synonym: "type 2 alveolocyte" EXACT []
synonym: "type 2 pneumocyte" EXACT []
synonym: "type II alveolar cell" EXACT []
synonym: "type II alveolar epithelial cell" EXACT []
synonym: "type II alveolocyte" EXACT []
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0000322 ! pneumocyte
intersection_of: CL:0000322 ! pneumocyte
intersection_of: RO:0002215 GO:0032940
intersection_of: RO:0002215 GO:0043129
relationship: RO:0002202 CL:4040003 ! fetal pre-type II pneumocyte
[Term]
id: CL:0002067
name: type A enteroendocrine cell
def: "An enteroendocrine cell that produces glucagon." []
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000170 ! glucagon secreting cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: RO:0002215 GO:0070091
[Term]
id: CL:0002068
name: Purkinje myocyte
def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." []
synonym: "myocytus conducens cardiacus" EXACT []
synonym: "Purkinje cell fiber" EXACT []
synonym: "Purkinje muscle cell" EXACT []
is_a: CL:0002086 ! specialized cardiac myocyte
[Term]
id: CL:0002071
name: enterocyte of epithelium of large intestine
def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." []
synonym: "columnar cell" BROAD []
synonym: "columnar cell of the colon" EXACT []
synonym: "vacuolar absorptive cell" EXACT []
is_a: CL:0000584 ! enterocyte
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000584 ! enterocyte
intersection_of: BFO:0000050 UBERON:0001278
[Term]
id: CL:0002072
name: nodal myocyte
def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." []
synonym: "cardiac pacemaker cell" EXACT []
synonym: "myocytus nodalis" EXACT []
synonym: "P cell" EXACT []
synonym: "pacemaker cell" BROAD []
is_a: CL:0002086 ! specialized cardiac myocyte
[Term]
id: CL:0002076
name: endo-epithelial cell
def: "An epithelial cell derived from endoderm." []
is_a: CL:0000066 ! epithelial cell
relationship: RO:0002202 CL:0000223 ! endodermal cell
[Term]
id: CL:0002077
name: ecto-epithelial cell
def: "An epithelial cell derived from ectoderm." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002202 CL:0000221 ! ectodermal cell
[Term]
id: CL:0002078
name: meso-epithelial cell
def: "Epithelial cell derived from mesoderm or mesenchyme." []
synonym: "epithelial mesenchymal cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002202 CL:0000222 ! mesodermal cell
[Term]
id: CL:0002085
name: tanycyte
def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." []
synonym: "stretch cell" EXACT []
is_a: CL:0000683 ! ependymoglial cell
[Term]
id: CL:0002086
name: specialized cardiac myocyte
def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." []
is_a: CL:0000746 ! cardiac muscle cell
[Term]
id: CL:0002087
name: nongranular leukocyte
def: "A leukocyte that lacks granules." []
synonym: "agranular leukocyte" EXACT []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: lacks_part GO:0030141
[Term]
id: CL:0002088
name: interstitial cell of Cajal
def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." []
synonym: "ICC" EXACT []
synonym: "intestinal pacemaker cell" EXACT []
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: RO:0002215 GO:0043134
[Term]
id: CL:0002092
name: bone marrow cell
def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." []
is_a: CL:0001035 ! bone cell
intersection_of: CL:0001035 ! bone cell
intersection_of: BFO:0000050 UBERON:0002371
[Term]
id: CL:0002097
name: cortical cell of adrenal gland
def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." []
synonym: "adrenal cortex cell" EXACT []
synonym: "adrenocortical cell" EXACT []
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1001601 ! adrenal gland glandular cell
intersection_of: CL:0002078 ! meso-epithelial cell
intersection_of: BFO:0000050 UBERON:0001235
[Term]
id: CL:0002098
name: regular cardiac myocyte
def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." []
synonym: "regular cardiac muscle cell" EXACT []
synonym: "regular cardiac muscle fiber" EXACT []
is_a: CL:0000746 ! cardiac muscle cell
[Term]
id: CL:0002101
name: CD38-positive naive B cell
def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." []
synonym: "CD38+ naive B cell" EXACT []
synonym: "CD38+ naive B lymphocyte" EXACT []
synonym: "CD38+ naive B-cell" EXACT []
synonym: "CD38+ naive B-lymphocyte" EXACT []
synonym: "CD38-positive naive B lymphocyte" EXACT []
synonym: "CD38-positive naive B-cell" EXACT []
synonym: "CD38-positive naive B-lymphocyte" EXACT []
is_a: CL:0000788 ! naive B cell
intersection_of: CL:0000788 ! naive B cell
intersection_of: RO:0002104 PR:000001408
[Term]
id: CL:0002102
name: CD38-negative naive B cell
def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." []
synonym: "CD38- naive B cell" EXACT []
synonym: "CD38- naive B lymphocyte" EXACT []
synonym: "CD38- naive B-cell" EXACT []
synonym: "CD38- naive B-lymphocyte" EXACT []
synonym: "CD38-negative naive B lymphocyte" EXACT []
synonym: "CD38-negative naive B-cell" EXACT []
synonym: "CD38-negative naive B-lymphocyte" EXACT []
is_a: CL:0000788 ! naive B cell
intersection_of: CL:0000788 ! naive B cell
intersection_of: lacks_plasma_membrane_part PR:000001408
[Term]
id: CL:0002103
name: IgG-positive double negative memory B cell
def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." []
synonym: "IgG+ dn memory B cell" EXACT []
synonym: "IgG+ dn memory B lymphocyte" EXACT []
synonym: "IgG+ dn memory B-cell" EXACT []
synonym: "IgG+ dn memory B-lymphocyte" EXACT []
synonym: "IgG+ double negative memory B cell" EXACT []
synonym: "IgG+ double negative memory B lymphocyte" EXACT []
synonym: "IgG+ double negative memory B-cell" EXACT []
synonym: "IgG+ double negative memory B-lymphocyte" EXACT []
synonym: "IgG-positive dn memory B cell" EXACT []
synonym: "IgG-positive dn memory B lymphocyte" EXACT []
synonym: "IgG-positive dn memory B-cell" EXACT []
synonym: "IgG-positive dn memory B-lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B-cell" EXACT []
synonym: "IgG-positive double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 ! double negative memory B cell
intersection_of: CL:0000981 ! double negative memory B cell
intersection_of: RO:0002104 GO:0071735
[Term]
id: CL:0002104
name: IgG-negative double negative memory B cell
def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." []
synonym: "IgG- dn memory B cell" EXACT []
synonym: "IgG- dn memory B lymphocyte" EXACT []
synonym: "IgG- dn memory B-cell" EXACT []
synonym: "IgG- dn memory B-lymphocyte" EXACT []
synonym: "IgG- double negative memory B cell" EXACT []
synonym: "IgG- double negative memory B lymphocyte" EXACT []
synonym: "IgG- double negative memory B-cell" EXACT []
synonym: "IgG- double negative memory B-lymphocyte" EXACT []
synonym: "IgG-negative dn memory B cell" EXACT []
synonym: "IgG-negative dn memory B lymphocyte" EXACT []
synonym: "IgG-negative dn memory B-cell" EXACT []
synonym: "IgG-negative dn memory B-lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B-cell" EXACT []
synonym: "IgG-negative double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 ! double negative memory B cell
intersection_of: CL:0000981 ! double negative memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071735
[Term]
id: CL:0002105
name: CD38-positive IgG memory B cell
def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." []
synonym: "CD38+ IgG memory B cell" EXACT []
synonym: "CD38+ IgG memory B lymphocyte" EXACT []
synonym: "CD38+ IgG memory B-cell" EXACT []
synonym: "CD38+ IgG memory B-lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B-cell" EXACT []
synonym: "CD38-positive IgG memory B-lymphocyte" EXACT []
is_a: CL:0000979 ! IgG memory B cell
intersection_of: CL:0000979 ! IgG memory B cell
intersection_of: RO:0002104 PR:000001408
[Term]
id: CL:0002106
name: IgD-positive CD38-positive IgG memory B cell
def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." []
is_a: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: RO:0002104 GO:0071738
[Term]
id: CL:0002107
name: IgD-negative CD38-positive IgG memory B cell
def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." []
is_a: CL:0001053 ! IgD-negative memory B cell
is_a: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
[Term]
id: CL:0002108
name: CD38-negative IgG memory B cell
def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." []
is_a: CL:0000979 ! IgG memory B cell
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000979 ! IgG memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738
intersection_of: lacks_plasma_membrane_part PR:000001408
[Term]
id: CL:0002109
name: B220-positive CD38-positive naive B cell
def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." []
synonym: "B220+CD38+ naive B cell" EXACT []
synonym: "B220+CD38+ naive B lymphocyte" EXACT []
synonym: "B220+CD38+ naive B-cell" EXACT []
synonym: "B220+CD38+ naive B-lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B-cell" EXACT []
synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT []
synonym: "CD38+B220+ naive B cell" EXACT []
synonym: "CD38+B220+ naive B lymphocyte" EXACT []
synonym: "CD38+B220+ naive B-cell" EXACT []
synonym: "CD38+B220+ naive B-lymphocyte" EXACT []
is_a: CL:0002101 ! CD38-positive naive B cell
intersection_of: CL:0002101 ! CD38-positive naive B cell
intersection_of: RO:0002104 PR:000001014
[Term]
id: CL:0002110
name: B220-low CD38-positive naive B cell
def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." []
is_a: CL:0002101 ! CD38-positive naive B cell
intersection_of: CL:0002101 ! CD38-positive naive B cell
intersection_of: RO:0015016 PR:000001014
[Term]
id: CL:0002111
name: CD38-negative unswitched memory B cell
def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." []
synonym: "CD38- unswitched memory B cell" EXACT []
synonym: "CD38- unswitched memory B lymphocyte" EXACT []
synonym: "CD38- unswitched memory B-cell" EXACT []
synonym: "CD38- unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B-cell" EXACT []
synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 ! unswitched memory B cell
intersection_of: CL:0000970 ! unswitched memory B cell
intersection_of: lacks_plasma_membrane_part PR:000001408
[Term]
id: CL:0002112
name: B220-positive CD38-negative unswitched memory B cell
def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: RO:0002104 PR:000001014
[Term]
id: CL:0002113
name: B220-low CD38-negative unswitched memory B cell
def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: RO:0015016 PR:000001014
[Term]
id: CL:0002114
name: CD38-positive unswitched memory B cell
def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." []
synonym: "CD38+ unswitched memory B cell" EXACT []
synonym: "CD38+ unswitched memory B lymphocyte" EXACT []
synonym: "CD38+ unswitched memory B-cell" EXACT []
synonym: "CD38+ unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B-cell" EXACT []
synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 ! unswitched memory B cell
intersection_of: CL:0000970 ! unswitched memory B cell
intersection_of: RO:0002104 PR:000001408
[Term]
id: CL:0002115
name: B220-positive CD38-positive unswitched memory B cell
def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: RO:0002104 PR:000001014
[Term]
id: CL:0002116
name: B220-low CD38-positive unswitched memory B cell
def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: RO:0015016 PR:000001014
[Term]
id: CL:0002117
name: IgG-negative class switched memory B cell
def: "A class switched memory B cell that lacks IgG on the cell surface." []
synonym: "IgG- class switched memory B cell" EXACT []
synonym: "IgG- class switched memory B lymphocyte" EXACT []
synonym: "IgG- class switched memory B-cell" EXACT []
synonym: "IgG- class switched memory B-lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B-cell" EXACT []
synonym: "IgG-negative class switched memory B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071735
[Term]
id: CL:0002118
name: CD38-negative IgG-negative class switched memory B cell
def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." []
is_a: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: lacks_plasma_membrane_part PR:000001408
[Term]
id: CL:0002119
name: CD38-positive IgG-negative class switched memory B cell
def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." []
is_a: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: RO:0002104 PR:000001408
[Term]
id: CL:0002120
name: CD24-positive CD38-negative IgG-negative class switched memory B cell
def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." []
is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: RO:0002104 PR:000001932
[Term]
id: CL:0002121
name: CD24-negative CD38-negative IgG-negative class switched memory B cell
def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." []
is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: lacks_plasma_membrane_part PR:000001932
[Term]
id: CL:0002122
name: B220-positive CD38-positive IgG-negative class switched memory B cell
def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." []
is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: RO:0002104 PR:000001014
[Term]
id: CL:0002123
name: B220-low CD38-positive IgG-negative class switched memory B cell
def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." []
is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: RO:0015016 PR:000001014
[Term]
id: CL:0002124
name: CD27-positive gamma-delta T cell
def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." []
synonym: "gammadelta27-positive" EXACT []
synonym: "gd27-positive" EXACT []
is_a: CL:0000800 ! mature gamma-delta T cell
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: RO:0002104 PR:000001963
intersection_of: RO:0002215 GO:0032609
intersection_of: RO:0002353 GO:0030217
relationship: RO:0002202 CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell
[Term]
id: CL:0002125
name: CD27-negative gamma-delta T cell
def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." []
synonym: "gammadelta-17 cells" EXACT []
is_a: CL:0000800 ! mature gamma-delta T cell
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: BFO:0000051 PR:000003455
intersection_of: lacks_plasma_membrane_part PR:000001963
intersection_of: RO:0002215 GO:0032620
intersection_of: RO:0002353 GO:0030217
relationship: RO:0002202 CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell
[Term]
id: CL:0002126
name: CD25-positive, CD27-positive immature gamma-delta T cell
def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." []
is_a: CL:0000799 ! immature gamma-delta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000799 ! immature gamma-delta T cell
intersection_of: BFO:0000050 UBERON:0002370
intersection_of: RO:0002104 PR:000001380
intersection_of: RO:0002104 PR:000001919
intersection_of: RO:0015015 PR:000001307
intersection_of: RO:0015015 PR:000001318
intersection_of: RO:0015015 PR:000001932
intersection_of: RO:0015016 PR:000001083
intersection_of: RO:0015016 PR:000001839
[Term]
id: CL:0002127
name: innate effector T cell
def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." []
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: RO:0002215 GO:0045087
[Term]
id: CL:0002129
name: regular atrial cardiac myocyte
def: "Regular cardiac myocyte of a cardiac atrium." []
synonym: "atrial cardiac muscle cell" EXACT []
synonym: "atrial myocyte" EXACT []
synonym: "regular atrial cardiac muscle fiber" EXACT []
synonym: "regular cardiac muscle cell of atrium" EXACT []
is_a: CL:0002098 ! regular cardiac myocyte
[Term]
id: CL:0002131
name: regular ventricular cardiac myocyte
def: "Regular cardiac myocyte of a cardiac ventricle." []
synonym: "regular cardiac muscle cell of ventricle" EXACT []
synonym: "regular ventricular cardiac muscle fiber" EXACT []
synonym: "ventricular cardiac muscle cell" BROAD []
synonym: "ventricular myocyte" EXACT []
is_a: CL:0002098 ! regular cardiac myocyte
[Term]
id: CL:0002132
name: stromal cell of ovary
def: "A stomal cell of the ovary" []
synonym: "ovarian stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0000992
[Term]
id: CL:0002138
name: endothelial cell of lymphatic vessel
def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." []
synonym: "LEC" EXACT []
synonym: "lymphatic endothelial cell" EXACT []
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: BFO:0000050 UBERON:0001473
intersection_of: RO:0002202 CL:0005022 ! vascular lymphangioblast
[Term]
id: CL:0002139
name: endothelial cell of vascular tree
def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." []
synonym: "cubodial endothelial cell of vascular tree" NARROW []
synonym: "vascular endothelial cell" EXACT []
is_a: CL:0000115 ! endothelial cell
[Term]
id: CL:0002140
name: acinar cell of sebaceous gland
def: "A sebum secreting cell of the skin that secretes sebum into the hair follicles." []
synonym: "sebocyte" BROAD []
is_a: CL:0000317 ! sebum secreting cell
is_a: CL:0000622 ! acinar cell
is_a: CL:1000448 ! epithelial cell of sweat gland
intersection_of: CL:0000317 ! sebum secreting cell
intersection_of: BFO:0000050 UBERON:0003487
[Term]
id: CL:0002145
name: ciliated columnar cell of tracheobronchial tree
def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0005012 ! multi-ciliated epithelial cell
is_a: CL:4030034 ! respiratory ciliated cell
relationship: RO:0002202 CL:0002209 ! intermediate epitheliocyte
[Term]
id: CL:0002148
name: dental pulp cell
def: "A cell found within the dental pulp." []
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0002159 ! general ecto-epithelial cell
intersection_of: BFO:0000050 UBERON:0001754
[Term]
id: CL:0002149
name: epithelial cell of uterus
def: "An epithelial cell of the uterus." []
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: BFO:0000050 UBERON:0000995
[Term]
id: CL:0002153
name: corneocyte
def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000311 ! keratin accumulating cell
relationship: BFO:0000050 UBERON:0002027
relationship: RO:0002202 CL:0000312 ! keratinocyte
[Term]
id: CL:0002159
name: general ecto-epithelial cell
def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." []
is_a: CL:0002077 ! ecto-epithelial cell
[Term]
id: CL:0002167
name: olfactory epithelial cell
def: "A specialized cell involved in sensory perception of smell." []
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002215 GO:0050911
[Term]
id: CL:0002174
name: follicular cell of ovary
def: "A cell within the follicle of an ovary." []
is_a: CL:0000500 ! follicular epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0002178
name: epithelial cell of stomach
def: "An epithelial cell found in the lining of the stomach." []
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000945
[Term]
id: CL:0002187
name: basal cell of epidermis
def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." []
is_a: CL:0000312 ! keratinocyte
is_a: CL:0000646 ! basal cell
is_a: CL:0011026 ! progenitor cell
is_a: CL:1000428 ! stem cell of epidermis
intersection_of: CL:0000646 ! basal cell
intersection_of: BFO:0000050 UBERON:0001003
[Term]
id: CL:0002188
name: glomerular endothelial cell
def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." []
is_a: CL:0000115 ! endothelial cell
is_a: CL:0000666 ! fenestrated cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000074
[Term]
id: CL:0002191
name: granulocytopoietic cell
def: "A cell involved in the formation of a granulocyte." []
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030851
[Term]
id: CL:0002192
name: metamyelocyte
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." []
is_a: CL:0002191 ! granulocytopoietic cell
relationship: RO:0002202 CL:0002193 ! myelocyte
[Term]
id: CL:0002193
name: myelocyte
def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." []
is_a: CL:0002191 ! granulocytopoietic cell
relationship: RO:0002202 CL:0000836 ! promyelocyte
[Term]
id: CL:0002194
name: monopoietic cell
def: "A cell involved in the formation of a monocyte (monopoiesis)." []
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030224
[Term]
id: CL:0002195
name: hepatic stem cell
def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." []
synonym: "HpSC" RELATED []
is_a: CL:0000048 ! multi fate stem cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: BFO:0000050 UBERON:0002107
[Term]
id: CL:0002202
name: epithelial cell of tracheobronchial tree
def: "An epithelial cell of the tracheobronchial tree." []
is_a: CL:0002632 ! epithelial cell of lower respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0007196
[Term]
id: CL:0002209
name: intermediate epitheliocyte
def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." []
synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
[Term]
id: CL:0002218
name: immature dendritic epithelial T cell precursor
def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." []
synonym: "immature DEC precursor" EXACT []
synonym: "immature DETC precursor" EXACT []
is_a: CL:0002404 ! fetal thymocyte
[Term]
id: CL:0002222
name: vertebrate lens cell
def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000306 ! crystallin accumulating cell
relationship: BFO:0000050 UBERON:0000965
[Term]
id: CL:0002231
name: epithelial cell of prostate
def: "An epithelial cell of the prostate." []
synonym: "prostate epithelial cell" EXACT []
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: BFO:0000050 UBERON:0002367
[Term]
id: CL:0002233
name: epithelial cell of prostatic acinus
def: "An epithelial cell of the prostatic acinus." []
synonym: "acinar epithelial cell of prostate" EXACT []
is_a: CL:0002231 ! epithelial cell of prostate
intersection_of: CL:0002231 ! epithelial cell of prostate
intersection_of: BFO:0000050 UBERON:0004179
[Term]
id: CL:0002234
name: basal cell of prostatic acinus
def: "A cell of the basal layer of the epithelium in the prostatic acinus." []
synonym: "basal epithelial cell of prostatic acinus" EXACT []
is_a: CL:0002233 ! epithelial cell of prostatic acinus
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0002341 ! basal cell of prostate epithelium
intersection_of: BFO:0000050 UBERON:0004179
[Term]
id: CL:0002240
name: marrow fibroblast
def: "A fibroblast in the bone marrow." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002371
[Term]
id: CL:0002242
name: nucleate cell
def: "A cell containing at least one nucleus." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0002505
[Term]
id: CL:0002251
name: epithelial cell of alimentary canal
def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." []
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001555
[Term]
id: CL:0002252
name: epithelial cell of esophagus
def: "An epithelial cell of the esophagus." []
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001043
[Term]
id: CL:0002253
name: epithelial cell of large intestine
def: "An epithelial cell of the large intestine." []
synonym: "epithelial cell of colon" RELATED []
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: BFO:0000050 UBERON:0000059
[Term]
id: CL:0002254
name: epithelial cell of small intestine
def: "An epithelial cell of the small intestine." []
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: BFO:0000050 UBERON:0002108
[Term]
id: CL:0002257
name: epithelial cell of thyroid gland
def: "An epithelial cell of thyroid gland." []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: BFO:0000050 UBERON:0002046
[Term]
id: CL:0002260
name: epithelial cell of parathyroid gland
def: "An epithelial cell of the parathyroid gland." []
is_a: CL:0002076 ! endo-epithelial cell
is_a: CL:1001593 ! parathyroid glandular cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: BFO:0000050 UBERON:0001132
[Term]
id: CL:0002264
name: type A cell of stomach
def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." []
is_a: CL:0002067 ! type A enteroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0002067 ! type A enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0000945
[Term]
id: CL:0002265
name: type D cell of colon
def: "A D cell located in the colon." []
synonym: "colon D-cell" EXACT []
synonym: "colonic delta cell" EXACT []
synonym: "delta cell of colon" EXACT []
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0002658 ! glandular cell of the large intestine
is_a: CL:0009042 ! enteroendocrine cell of colon
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0001155
[Term]
id: CL:0002266
name: type D cell of small intestine
def: "A type D cell of the small intestine." []
synonym: "delta cell of small intestine" EXACT []
synonym: "small intestine D-cell" EXACT []
synonym: "small intestine delta cell" EXACT []
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0002254 ! epithelial cell of small intestine
is_a: CL:0009006 ! enteroendocrine cell of small intestine
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0002108
[Term]
id: CL:0002267
name: type D cell of stomach
def: "A type D cell found in the stomach." []
synonym: "delta cell of stomach" EXACT []
synonym: "stomach D-cell" EXACT []
synonym: "stomach delta cell" EXACT []
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0000945
[Term]
id: CL:0002274
name: histamine secreting cell
def: "A cell type that secretes histamine." []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0001821
[Term]
id: CL:0002275
name: pancreatic PP cell
def: "A PP cell located in the islets of the pancreas." []
synonym: "pancreatic polypeptide-secreting cell" EXACT []
synonym: "PP cell of pancreatic islet" EXACT []
synonym: "PP-cell of pancreatic islet" EXACT []
is_a: CL:0000696 ! PP cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000696 ! PP cell
intersection_of: BFO:0000050 UBERON:0000006
intersection_of: BFO:0000050 UBERON:0001264
[Term]
id: CL:0002293
name: epithelial cell of thymus
def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." []
synonym: "epithelial cell of thymus gland" EXACT []
synonym: "epithelial reticular cell" EXACT []
synonym: "epithelial reticular cell of thymus" EXACT []
synonym: "thymic epithelial cell" EXACT []
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: BFO:0000050 UBERON:0002370
[Term]
id: CL:0002301
name: type B synovial cell
def: "A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles." []
synonym: "fibroblast-like synoviocyte" EXACT []
synonym: "synovial fibroblast" EXACT []
is_a: CL:0000214 ! synovial cell
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0002018
relationship: RO:0002215 GO:0030213
relationship: RO:0003000 UBERON:0001090
[Term]
id: CL:0002305
name: epithelial cell of distal tubule
def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." []
synonym: "kidney distal tubule epithelial cell" EXACT []
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000494 ! nephron tubule epithelial cell
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004135
relationship: BFO:0000050 UBERON:0004135
[Term]
id: CL:0002306
name: epithelial cell of proximal tubule
def: "An epithelial cell of the proximal tubule of the kidney." []
synonym: "kidney proximal tubule epithelial cell" EXACT []
is_a: CL:0000239 ! brush border epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000494 ! nephron tubule epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004134
relationship: BFO:0000050 UBERON:0004134
[Term]
id: CL:0002313
name: endocrine-paracrine cell of prostate gland
def: "An ecto-epithelial cell of the prostate gland that secretes hormones." []
synonym: "glandular cell of prostate" EXACT []
synonym: "neuro-epithelial cell of prostate gland" EXACT []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0002159 ! general ecto-epithelial cell
intersection_of: BFO:0000050 UBERON:0002367
intersection_of: RO:0002215 GO:0046879
[Term]
id: CL:0002319
name: neural cell
def: "A cell that is part of the nervous system." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001016
[Term]
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002384
[Term]
id: CL:0002321
name: embryonic cell (metazoa)
def: "A cell of the embryo." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0002322
name: embryonic stem cell
def: "A stem cell of embryonic origin." []
synonym: "ESC" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:0002321 ! embryonic cell (metazoa)
[Term]
id: CL:0002323
name: amniocyte
def: "A cell of aÂ fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." []
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: RO:0001025 UBERON:0000173
[Term]
id: CL:0002325
name: lactocyte
def: "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland." []
synonym: "epithelial cell of lactiferous gland" EXACT []
synonym: "lactaction-associated mammary epithelial cell" EXACT []
synonym: "lactation-derived mammary cell" EXACT []
synonym: "LMC" RELATED []
synonym: "luminal cell of alveolus of lactiferous gland" EXACT []
synonym: "mammary alveolar cell" BROAD []
synonym: "mammary alveolar epithelial cell" EXACT []
synonym: "mammary gland alveolar epithelial cell" EXACT []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000314 ! milk secreting cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0003214
relationship: RO:0002202 CL:4033057 ! luminal adaptive secretory precursor cell of mammary gland
[Term]
id: CL:0002326
name: luminal epithelial cell of mammary gland
def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." []
synonym: "mature luminal cell" BROAD []
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:0002327 ! mammary gland epithelial cell
relationship: RO:0002202 CL:0009116 ! progenitor cell of mammary luminal epithelium
[Term]
id: CL:0002327
name: mammary gland epithelial cell
def: "An epithelial cell of the mammary gland." []
synonym: "breast epithelial cell" EXACT []
synonym: "mammary epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001911
[Term]
id: CL:0002328
name: bronchial epithelial cell
def: "An epithelial cell of the bronchus." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002185
relationship: BFO:0000050 UBERON:0002031
[Term]
id: CL:0002329
name: basal epithelial cell of tracheobronchial tree
def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
[Term]
id: CL:0002332
name: ciliated cell of the bronchus
def: "A ciliated cell of the bronchus." []
is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree
is_a: CL:0002328 ! bronchial epithelial cell
intersection_of: CL:0000064 ! ciliated cell
intersection_of: BFO:0000050 UBERON:0002185
[Term]
id: CL:0002333
name: neural crest derived adipocyte
def: "An adipocyte derived from a neural crest cell." []
is_a: CL:0000136 ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell
relationship: RO:0002202 CL:0000005 ! fibroblast neural crest derived
[Term]
id: CL:0002334
name: preadipocyte
def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." []
is_a: CL:0000057 ! fibroblast
[Term]
id: CL:0002335
name: brown preadipocyte
def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." []
is_a: CL:0002334 ! preadipocyte
[Term]
id: CL:0002338
name: CD56-positive, CD161-positive immature natural killer cell, human
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." []
synonym: "p-NK" RELATED []
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: RO:0002104 PR:000001024
intersection_of: RO:0002104 PR:000001381
intersection_of: RO:0002104 PR:000001874
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002162 NCBITaxon:9606
relationship: RO:0002202 CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell, human
[Term]
id: CL:0002339
name: prostate stem cell
def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." []
synonym: "CD133-positive prostate epithelial cell" EXACT []
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0000034 ! stem cell
intersection_of: BFO:0000050 UBERON:0002367
[Term]
id: CL:0002341
name: basal cell of prostate epithelium
def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." []
is_a: CL:0002231 ! epithelial cell of prostate
[Term]
id: CL:0002344
name: CD56-negative, CD161-positive immature natural killer cell, human
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." []
synonym: "p-NK" RELATED []
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000001003
intersection_of: lacks_plasma_membrane_part PR:000001024
intersection_of: RO:0002104 PR:000001381
intersection_of: RO:0002104 PR:000001874
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002162 NCBITaxon:9606
[Term]
id: CL:0002346
name: Dx5-negative, NK1.1-positive immature natural killer cell, mouse
def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." []
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000001008
intersection_of: RO:0002104 PR:000002977
intersection_of: RO:0002162 NCBITaxon:10090
[Term]
id: CL:0002350
name: endocardial cell
def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." []
synonym: "endocardial endothelial cell" EXACT []
synonym: "endothelial cell of endocardium" EXACT []
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0002165
[Term]
id: CL:0002351
name: progenitor cell of endocrine pancreas
def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." []
synonym: "pancreatic endocrine progenitor" EXACT []
synonym: "pancreatic islet progenitor cell" EXACT []
is_a: CL:0011026 ! progenitor cell
[Term]
id: CL:0002352
name: gestational hematopoietic stem cell
def: "A hematopoietic stem cell that exists during embryogenesis." []
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: BFO:0000050 UBERON:0000922
[Term]
id: CL:0002353
name: fetal liver hematopoietic progenitor cell
def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." []
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: lacks_plasma_membrane_part PR:000001308
intersection_of: lacks_plasma_membrane_part PR:000001896
intersection_of: RO:0002104 GO:0042611
intersection_of: RO:0002104 PR:000001006
intersection_of: RO:0002104 PR:000001833
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002037
intersection_of: RO:0002104 PR:000002979
relationship: BFO:0000050 UBERON:0002107
[Term]
id: CL:0002354
name: yolk sac hematopoietic stem cell
def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." []
synonym: "hemangioblast precursor" EXACT []
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: lacks_plasma_membrane_part GO:0042611
intersection_of: lacks_plasma_membrane_part PR:000001006
intersection_of: lacks_plasma_membrane_part PR:000002979
intersection_of: RO:0002104 PR:000001307
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002037
relationship: BFO:0000050 UBERON:0001040
[Term]
id: CL:0002355
name: primitive red blood cell
def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." []
synonym: "primitive erythroblast" EXACT []
synonym: "primitive erythrocyte" EXACT []
synonym: "primitive erythroid cell" EXACT []
is_a: CL:0002417 ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: BFO:0000050 UBERON:0000922
intersection_of: BFO:0000051 PR:000008467
intersection_of: BFO:0000051 PR:000008857
intersection_of: RO:0000053 PATO:0000586
relationship: RO:0002202 CL:0002361 ! primitive erythroid progenitor
[Term]
id: CL:0002356
name: primitive reticulocyte
def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." []
synonym: "megalocyte" EXACT []
is_a: CL:0002417 ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: RO:0000053 PATO:0000586
intersection_of: RO:0002202 CL:0002355 ! primitive red blood cell
[Term]
id: CL:0002357
name: fetal derived definitive erythrocyte
def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." []
synonym: "macrocyte" EXACT []
is_a: CL:0000595 ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: BFO:0000050 UBERON:0000922
intersection_of: BFO:0000051 PR:000008857
relationship: RO:0002202 CL:0002353 ! fetal liver hematopoietic progenitor cell
[Term]
id: CL:0002358
name: pyrenocyte
def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." []
is_a: CL:0002417 ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: RO:0000053 PATO:0000587
intersection_of: RO:0002202 CL:0002355 ! primitive red blood cell
[Term]
id: CL:0002359
name: placental hematopoietic stem cell
def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." []
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: BFO:0000050 UBERON:0001987
[Term]
id: CL:0002361
name: primitive erythroid progenitor
def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." []
synonym: "EryP-CFC" EXACT []
synonym: "inner blood island hemangioblast" EXACT []
is_a: CL:0002417 ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: RO:0002104 PR:000009127
relationship: RO:0002202 CL:0002418 ! hemangioblast
[Term]
id: CL:0002362
name: cerebellar granule cell precursor
def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." []
synonym: "GCP" RELATED []
synonym: "granule cell precursor" BROAD []
synonym: "granule cell progenitor" BROAD []
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: BFO:0000050 UBERON:0009841
[Term]
id: CL:0002363
name: keratocyte
def: "A keratocyte is a specialized fibroblastÂ residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. ThisÂ cornealÂ layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." []
synonym: "corneal fibroblast" EXACT []
synonym: "corneal keratocyte" EXACT []
is_a: CL:0000005 ! fibroblast neural crest derived
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001777
relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell
[Term]
id: CL:0002367
name: trabecular meshwork cell
def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." []
synonym: "trabeculocyte" EXACT []
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0005969
[Term]
id: CL:0002368
name: respiratory epithelial cell
def: "An endo-epithelial cell of the respiratory tract." []
synonym: "airway epithelial cell" EXACT []
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: BFO:0000050 UBERON:0000065
[Term]
id: CL:0002369
name: fungal spore
def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." []
is_a: CL:0000521 ! fungal cell
[Term]
id: CL:0002370
name: respiratory goblet cell
def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." []
synonym: "respiratory mucosa goblet cells" EXACT []
is_a: CL:0000160 ! goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0000065
relationship: BFO:0000050 UBERON:0004802
[Term]
id: CL:0002372
name: myotube
def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." []
synonym: "myotubule" EXACT []
synonym: "single cell sarcomere" EXACT []
is_a: CL:0000187 ! muscle cell
is_a: CL:0000228 ! multinucleate cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000051 GO:0030017
intersection_of: RO:0000053 PATO:0001908
intersection_of: RO:0000053 PATO:0002478
[Term]
id: CL:0002374
name: ear hair cell
def: "A hair cell of the ear that contains the organs of balance and hearing." []
synonym: "ear receptor cell" EXACT []
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
intersection_of: BFO:0000050 UBERON:0001690
[Term]
id: CL:0002375
name: Schwann cell precursor
def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." []
synonym: "Schwann cell precursor cell" EXACT []
is_a: CL:0000030 ! glioblast
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0002377
name: immature Schwann cell
def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." []
synonym: "Schwann cell" BROAD []
is_a: CL:0002573 ! Schwann cell
relationship: RO:0002202 CL:0002375 ! Schwann cell precursor
[Term]
id: CL:0002385
name: blastoconidium
def: "An oblong or round asexual spore formed from conidial chains." []
synonym: "blastospore" RELATED []
is_a: CL:0000606 ! macroconidium
[Term]
id: CL:0002387
name: arthroconidium
def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." []
synonym: "arthrospore" RELATED []
is_a: CL:0000606 ! macroconidium
[Term]
id: CL:0002393
name: intermediate monocyte
def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." []
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: has_not_completed GO:0030224
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001199
intersection_of: lacks_plasma_membrane_part PR:000001289
relationship: RO:0002202 CL:0000860 ! classical monocyte
[Term]
id: CL:0002395
name: Gr1-high classical monocyte
def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." []
is_a: CL:0000860 ! classical monocyte
is_a: CL:0001022 ! CD115-positive monocyte
intersection_of: CL:0000860 ! classical monocyte
intersection_of: lacks_plasma_membrane_part PR:000001014
intersection_of: lacks_plasma_membrane_part PR:000001206
intersection_of: lacks_plasma_membrane_part PR:000001879
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000002062
intersection_of: RO:0015015 PR:000002980
[Term]
id: CL:0002396
name: CD14-low, CD16-positive monocyte
def: "A patrolling monocyte that is CD14-low and CD16-positive." []
synonym: "non-classical monocyte, human" EXACT []
is_a: CL:0000875 ! non-classical monocyte
intersection_of: CL:0000875 ! non-classical monocyte
intersection_of: RO:0002104 PR:000001483
intersection_of: RO:0015016 PR:000001889
relationship: RO:0002202 CL:0002397 ! CD14-positive, CD16-positive monocyte
[Term]
id: CL:0002397
name: CD14-positive, CD16-positive monocyte
def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." []
synonym: "CD16+ monocyte" EXACT []
is_a: CL:0001054 ! CD14-positive monocyte
intersection_of: CL:0001054 ! CD14-positive monocyte
intersection_of: lacks_plasma_membrane_part PR:000001199
intersection_of: RO:0002104 PR:000001483
[Term]
id: CL:0002398
name: Gr1-positive, CD43-positive monocyte
def: "An intermediate monocyte that is Gr1-positive, CD43-positive." []
is_a: CL:0001022 ! CD115-positive monocyte
is_a: CL:0002393 ! intermediate monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001879
intersection_of: RO:0002104 PR:000002062
intersection_of: RO:0002104 PR:000002980
relationship: RO:0002202 CL:0002395 ! Gr1-high classical monocyte
[Term]
id: CL:0002400
name: fraction B/C precursor B cell
def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." []
is_a: CL:0000817 ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: lacks_plasma_membrane_part GO:0071753
intersection_of: RO:0002104 PR:000001002
intersection_of: RO:0002104 PR:000001879
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0002104 PR:000002037
[Term]
id: CL:0002401
name: mature dendritic epithelial T cell precursor
def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." []
synonym: "mature DEC precursor" EXACT []
synonym: "mature DETC precursor" EXACT []
is_a: CL:0002404 ! fetal thymocyte
relationship: RO:0002202 CL:0002218 ! immature dendritic epithelial T cell precursor
[Term]
id: CL:0002402
name: Peyer's patch B cell
def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." []
synonym: "Peyers patch B cell" EXACT []
is_a: CL:0000822 ! B-2 B cell
is_a: CL:0009014 ! Peyer's patch lymphocyte
intersection_of: CL:0000785 ! mature B cell
intersection_of: BFO:0000050 UBERON:0001211
intersection_of: lacks_plasma_membrane_part PR:000001839
intersection_of: lacks_plasma_membrane_part PR:000001879
intersection_of: lacks_plasma_membrane_part PR:000002037
intersection_of: RO:0002104 GO:0071753
intersection_of: RO:0002104 PR:000001014
intersection_of: RO:0002104 PR:000001289
intersection_of: RO:0002104 PR:000001338
[Term]
id: CL:0002404
name: fetal thymocyte
def: "A thymocyte found in the fetal thymus." []
is_a: CL:0000893 ! thymocyte
[Term]
id: CL:0002405
name: gamma-delta thymocyte
def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." []
synonym: "gammadelta thymocyte" EXACT []
synonym: "gd thymocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000025402
intersection_of: RO:0002104 GO:0042106
[Term]
id: CL:0002410
name: pancreatic stellate cell
def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." []
synonym: "pancreas stellate cell" EXACT []
synonym: "PaSC" EXACT []
is_a: CL:0000057 ! fibroblast
relationship: BFO:0000050 UBERON:0001264
[Term]
id: CL:0002417
name: primitive erythroid lineage cell
def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." []
is_a: CL:0000764 ! erythroid lineage cell
[Term]
id: CL:0002418
name: hemangioblast
def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." []
is_a: CL:0000222 ! mesodermal cell
relationship: RO:0002202 CL:0002354 ! yolk sac hematopoietic stem cell
[Term]
id: CL:0002419
name: mature T cell
def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." []
synonym: "CD3e-positive T cell" EXACT []
synonym: "CD3epsilon T cell" RELATED []
synonym: "mature T-cell" EXACT []
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042101
intersection_of: RO:0002353 GO:0045058
[Term]
id: CL:0002420
name: immature T cell
def: "A T cell that has not completed T cell selection." []
synonym: "immature T-cell" EXACT []
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: has_not_completed GO:0045058
[Term]
id: CL:0002421
name: nucleated reticulocyte
def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." []
is_a: CL:0000558 ! reticulocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000558 ! reticulocyte
intersection_of: RO:0000053 PATO:0002505
[Term]
id: CL:0002422
name: enucleated reticulocyte
def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000558 ! reticulocyte
intersection_of: CL:0000558 ! reticulocyte
intersection_of: BFO:0000051 GO:0005840
intersection_of: RO:0000053 PATO:0001405
[Term]
id: CL:0002423
name: DN2a thymocyte
def: "A DN2 thymocyte that is Kit-hi." []
is_a: CL:0000806 ! DN2 thymocyte
intersection_of: CL:0000806 ! DN2 thymocyte
intersection_of: RO:0015015 PR:000002065
[Term]
id: CL:0002424
name: DN2b thymocyte
def: "A DN2 thymocyte that is Kit-low." []
is_a: CL:0000806 ! DN2 thymocyte
intersection_of: CL:0000806 ! DN2 thymocyte
intersection_of: RO:0015016 PR:000002065
relationship: RO:0002202 CL:0002423 ! DN2a thymocyte
[Term]
id: CL:0002425
name: early T lineage precursor
def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." []
synonym: "ETP" EXACT []
synonym: "preT.ETP.Th" EXACT []
is_a: CL:0000827 ! pro-T cell
intersection_of: CL:0000827 ! pro-T cell
intersection_of: lacks_plasma_membrane_part PR:000001380
intersection_of: RO:0002104 PR:000001307
intersection_of: RO:0002104 PR:000001869
intersection_of: RO:0002104 PR:000002065
[Term]
id: CL:0002427
name: resting double-positive thymocyte
def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." []
synonym: "T.DP.sm.Th" EXACT []
is_a: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: RO:0000053 PATO:0000587
[Term]
id: CL:0002428
name: double-positive blast
def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." []
synonym: "activated double-positive thymocyte" EXACT []
synonym: "T.DPb.Th" EXACT []
is_a: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: RO:0000053 PATO:0000586
intersection_of: RO:0000056 GO:0008283
relationship: RO:0002202 CL:0002427 ! resting double-positive thymocyte
[Term]
id: CL:0002429
name: CD69-positive double-positive thymocyte
def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." []
synonym: "T.DP69+.Th" EXACT []
is_a: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: RO:0000056 GO:0043368
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0015016 GO:0042105
relationship: RO:0002202 CL:0002428 ! double-positive blast
[Term]
id: CL:0002430
name: CD4-intermediate, CD8-positive double-positive thymocyte
def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." []
synonym: "T.4int8+.Th" EXACT []
synonym: "T_4int8+_Th" EXACT []
is_a: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: RO:0000056 GO:0043368
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0015015 GO:0042105
intersection_of: RO:0015016 PR:000001004
relationship: RO:0002202 CL:0002429 ! CD69-positive double-positive thymocyte
[Term]
id: CL:0002431
name: CD4-positive, CD8-intermediate double-positive thymocyte
def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." []
synonym: "T.4+8int.Th" EXACT []
synonym: "T_4+8int_Th" EXACT []
is_a: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: RO:0000056 GO:0043368
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0015015 GO:0042105
intersection_of: RO:0015016 PR:000025402
relationship: RO:0002202 CL:0002429 ! CD69-positive double-positive thymocyte
[Term]
id: CL:0002432
name: CD24-positive, CD4 single-positive thymocyte
def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." []
synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT []
synonym: "T.4SP24int.Th" EXACT []
is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte
intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0015015 GO:0042105
relationship: RO:0002202 CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte
[Term]
id: CL:0002433
name: CD69-positive, CD4-positive single-positive thymocyte
def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." []
synonym: "intermediate CD4-single-positive" EXACT []
synonym: "T.4SP69+.Th" EXACT []
is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte
intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0015015 GO:0042105
relationship: RO:0002202 CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte
[Term]
id: CL:0002434
name: CD24-positive, CD8 single-positive thymocyte
def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." []
synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT []
synonym: "T.8SP24int.Th" EXACT []
is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte
intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte
intersection_of: RO:0002104 PR:000001932
intersection_of: RO:0015015 GO:0042105
relationship: RO:0002202 CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte
[Term]
id: CL:0002435
name: CD69-positive, CD8-positive single-positive thymocyte
def: "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." []
synonym: "intermediate CD8-single-positive" EXACT []
synonym: "T.8SP69+.Th" EXACT []
is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte
intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte
intersection_of: RO:0002104 PR:000001343
intersection_of: RO:0015015 GO:0042105
relationship: RO:0002202 CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte
[Term]
id: CL:0002436
name: mature CD4 single-positive thymocyte
def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." []
synonym: "T.4SP24-.Th" RELATED []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0015015 GO:0042105
intersection_of: RO:0015016 PR:000001932
relationship: RO:0002202 CL:0002432 ! CD24-positive, CD4 single-positive thymocyte
[Term]
id: CL:0002437
name: mature CD8 single-positive thymocyte
def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." []
synonym: "T.8SP24-.Th" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: RO:0015015 GO:0042105
intersection_of: RO:0015016 PR:000001932
relationship: RO:0002202 CL:0002434 ! CD24-positive, CD8 single-positive thymocyte
[Term]
id: CL:0002453
name: oligodendrocyte precursor cell
def: "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." []
synonym: "O-2A/OPC" RELATED []
synonym: "O2A/OPC" RELATED []
synonym: "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell" BROAD []
synonym: "oligodendrocyte/type-2 astrocyte progenitor cell" BROAD []
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000339 ! glioblast (sensu Vertebrata)
relationship: RO:0002215 GO:0030154
[Term]
id: CL:0002454
name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." []
synonym: "DC.8-4-11b+" EXACT []
synonym: "spleen double-negative dendritic cell" EXACT []
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
[Term]
id: CL:0002455
name: CD8_alpha-negative plasmacytoid dendritic cell
def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." []
synonym: "DC.pDC.8-" EXACT []
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: RO:0002104 PR:000001004
[Term]
id: CL:0002456
name: CD8_alpha-positive plasmacytoid dendritic cell
def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." []
synonym: "DC.pDC.8+" EXACT []
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: RO:0002104 PR:000001004
intersection_of: RO:0002104 PR:000001084
[Term]
id: CL:0002457
name: epidermal Langerhans cell
def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." []
is_a: CL:0000453 ! Langerhans cell
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0000453 ! Langerhans cell
intersection_of: RO:0001025 UBERON:0001003
intersection_of: RO:0002104 GO:0042613
intersection_of: RO:0002104 PR:000001012
intersection_of: RO:0002104 PR:000001014
[Term]
id: CL:0002460
name: CD8alpha-negative thymic conventional dendritic cell
def: "A conventional thymic dendritic cell that is CD8alpha-negative." []
synonym: "DC.8-.Th" EXACT []
is_a: CL:0000941 ! thymic conventional dendritic cell
intersection_of: CL:0000941 ! thymic conventional dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001084
[Term]
id: CL:0002462
name: adipose dendritic cell
def: "A F4/80-negative dendritic cell located in adipose tissue." []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: BFO:0000050 UBERON:0001013
intersection_of: lacks_plasma_membrane_part PR:000001813
relationship: RO:0002202 CL:0002010 ! pre-conventional dendritic cell
[Term]
id: CL:0002463
name: SIRPa-positive adipose dendritic cell
def: "An adipose dendritic cell that is SIRPa-positive." []
synonym: "DC.SIRPa+.Ad" EXACT []
is_a: CL:0002462 ! adipose dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0002104 PR:000001968
[Term]
id: CL:0002464
name: SIRPa-negative adipose dendritic cell
def: "An adipose dendritic cell that is SIRPa-negative." []
synonym: "DC.SIRPa-.Ad" EXACT []
is_a: CL:0002462 ! adipose dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001968
[Term]
id: CL:0002465
name: CD11b-positive dendritic cell
def: "A conventional dendritic cell that expresses CD11b (ITGAM)." []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0002104 PR:000001012
[Term]
id: CL:0002467
name: Gr1-high myeloid suppressor cell
def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." []
synonym: "MDS.Gr1hi" EXACT []
is_a: CL:0000889 ! myeloid suppressor cell
intersection_of: CL:0000889 ! myeloid suppressor cell
intersection_of: lacks_plasma_membrane_part PR:000001013
intersection_of: RO:0015015 PR:000002980
[Term]
id: CL:0002468
name: Gr1-low myeloid suppressor cell
def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." []
synonym: "MDS.Gr1lo" EXACT []
is_a: CL:0000889 ! myeloid suppressor cell
intersection_of: CL:0000889 ! myeloid suppressor cell
intersection_of: RO:0002104 PR:000001013
intersection_of: RO:0015016 PR:000002980
[Term]
id: CL:0002469
name: MHC-II-negative classical monocyte
def: "Gr1-high monocyte that lacks MHC-II receptor complex." []
synonym: "Mo.6C+II-" EXACT []
is_a: CL:0002395 ! Gr1-high classical monocyte
intersection_of: CL:0002395 ! Gr1-high classical monocyte
intersection_of: lacks_plasma_membrane_part GO:0042613
[Term]
id: CL:0002470
name: MHC-II-positive classical monocyte
def: "Gr1-high monocyte that has a MHC-II receptor complex." []
synonym: "Mo.6c+II" EXACT []
is_a: CL:0002395 ! Gr1-high classical monocyte
intersection_of: CL:0002395 ! Gr1-high classical monocyte
intersection_of: RO:0002104 GO:0042613
[Term]
id: CL:0002471
name: MHC-II-negative non-classical monocyte
def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." []
synonym: "Mo.6C-II-" EXACT []
is_a: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: lacks_plasma_membrane_part GO:0042613
[Term]
id: CL:0002472
name: MHC-II-low non-classical monocyte
def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." []
synonym: "Mo.6C-IIint" EXACT []
is_a: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: RO:0015016 GO:0042613
[Term]
id: CL:0002473
name: MHC-II-high non-classical monocyte
def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." []
synonym: "Mo.6C-II+" EXACT []
is_a: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: RO:0015015 GO:0042613
[Term]
id: CL:0002474
name: lymphoid MHC-II-negative classical monocyte
def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." []
is_a: CL:0002469 ! MHC-II-negative classical monocyte
intersection_of: CL:0002469 ! MHC-II-negative classical monocyte
intersection_of: lacks_plasma_membrane_part PR:000001013
intersection_of: RO:0002104 PR:000001813
intersection_of: RO:0015015 PR:000001012
[Term]
id: CL:0002475
name: lymphoid MHC-II-negative non-classical monocyte
def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." []
is_a: CL:0002471 ! MHC-II-negative non-classical monocyte
intersection_of: CL:0002471 ! MHC-II-negative non-classical monocyte
intersection_of: RO:0002104 PR:000001013
intersection_of: RO:0002104 PR:000001813
intersection_of: RO:0015015 PR:000001012
[Term]
id: CL:0002476
name: bone marrow macrophage
def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." []
synonym: "MF.BM" RELATED []
is_a: CL:0000864 ! tissue-resident macrophage
is_a: CL:0010004 ! mononuclear cell of bone marrow
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: lacks_plasma_membrane_part PR:000001014
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000002980
intersection_of: RO:0002104 PR:000001813
intersection_of: RO:0002104 PR:000002062
relationship: BFO:0000050 UBERON:0002371
[Term]
id: CL:0002477
name: adipose macrophage
def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." []
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: RO:0002104 PR:000001006
intersection_of: RO:0002104 PR:000001013
intersection_of: RO:0002104 PR:000001968
[Term]
id: CL:0002478
name: F4/80-negative adipose macrophage
def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." []
synonym: "MF.Autofl.Ad" EXACT []
is_a: CL:0002477 ! adipose macrophage
intersection_of: CL:0002477 ! adipose macrophage
intersection_of: lacks_plasma_membrane_part PR:000001813
intersection_of: RO:0002104 GO:0042613
[Term]
id: CL:0002479
name: F4/80-positive adipose macrophage
def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." []
synonym: "MF.F480+.Ad" EXACT []
is_a: CL:0002477 ! adipose macrophage
intersection_of: CL:0002477 ! adipose macrophage
intersection_of: lacks_plasma_membrane_part GO:0042613
intersection_of: RO:0002104 PR:000001813
[Term]
id: CL:0002483
name: hair follicle melanocyte
def: "A melanocyte that produces pigment within the hair follicle." []
is_a: CL:0000148 ! melanocyte
is_a: CL:0002559 ! hair follicle cell
intersection_of: CL:0000148 ! melanocyte
intersection_of: BFO:0000050 UBERON:0002073
[Term]
id: CL:0002484
name: epithelial melanocyte
def: "A melanocyte that produces pigment in the epithelium." []
is_a: CL:0000148 ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: BFO:0000050 UBERON:0000483
[Term]
id: CL:0002485
name: retinal melanocyte
def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." []
is_a: CL:0000148 ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: BFO:0000050 UBERON:0000966
[Term]
id: CL:0002488
name: trophoblast giant cell
def: "A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." []
synonym: "giant trophoblast cell" EXACT []
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: RO:0000053 PATO:0000586
intersection_of: RO:0002215 GO:0001974
[Term]
id: CL:0002489
name: double negative thymocyte
def: "A thymocyte that lacks expression of CD4 and CD8." []
synonym: "CD4-CD8- T cell" EXACT []
synonym: "double negative T cell" EXACT []
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000025402
[Term]
id: CL:0002491
name: auditory epithelial cell
def: "A specialized cell involved in auditory sensory perception." []
is_a: CL:0000098 ! sensory epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002215 GO:0050910
[Term]
id: CL:0002494
name: cardiocyte
def: "A cell located in the heart, including both muscle and non muscle cells." []
synonym: "heart cell" EXACT []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0007100
[Term]
id: CL:0002496
name: intraepithelial lymphocyte
def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." []
synonym: "IEL" EXACT []
synonym: "intraepithelial T cell" EXACT []
synonym: "intraepithelial T-cell" EXACT []
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: RO:0001025 UBERON:0001277
intersection_of: RO:0002215 GO:0002385
[Term]
id: CL:0002499
name: spongiotrophoblast cell
def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." []
synonym: "spongiotrophoblast" EXACT []
is_a: CL:0000351 ! trophoblast cell
relationship: BFO:0000050 UBERON:0004021
[Term]
id: CL:0002504
name: enteric smooth muscle cell
def: "A smooth muscle cell of the intestine." []
synonym: "intestinal smooth muscle cell" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0000160
[Term]
id: CL:0002507
name: langerin-positive lymph node dendritic cell
def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." []
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001004
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: RO:0002104 GO:0042613
intersection_of: RO:0002104 PR:000001293
[Term]
id: CL:0002518
name: kidney epithelial cell
def: "An epithelial cell of the kidney." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:1000497 ! kidney cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002113
[Term]
id: CL:0002520
name: nephrocyte
def: "An insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis." []
is_a: CL:0002522 ! renal filtration cell
relationship: RO:0002160 NCBITaxon:50557
[Term]
id: CL:0002522
name: renal filtration cell
def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." []
is_a: CL:0000424 ! excretory cell
relationship: BFO:0000050 UBERON:0001008
[Term]
id: CL:0002523
name: mesonephric podocyte
def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." []
synonym: "mesonephric glomerular visceral epithelial cell" EXACT []
is_a: CL:0000653 ! podocyte
intersection_of: CL:0000653 ! podocyte
intersection_of: BFO:0000050 UBERON:0000080
[Term]
id: CL:0002524
name: disseminated nephrocyte
def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." []
is_a: CL:0002520 ! nephrocyte
[Term]
id: CL:0002525
name: metanephric podocyte
def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." []
synonym: "metanephric glomerular visceral epithelial cell" EXACT []
is_a: CL:0000653 ! podocyte
intersection_of: CL:0000653 ! podocyte
intersection_of: BFO:0000050 UBERON:0000081
[Term]
id: CL:0002532
name: CD16-positive myeloid dendritic cell
def: "A myeloid dendritic cell found in the blood that is CD16-positive." []
synonym: "CD16+ mDC" EXACT []
synonym: "CD16-mDC" EXACT []
is_a: CL:0000782 ! myeloid dendritic cell
intersection_of: CL:0000782 ! myeloid dendritic cell
intersection_of: RO:0002104 PR:000001483
intersection_of: RO:0002215 GO:0032640
[Term]
id: CL:0002533
name: immature CD16-positive myeloid dendritic cell
def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." []
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0002532 ! CD16-positive myeloid dendritic cell
intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell
intersection_of: RO:0015016 GO:0042613
intersection_of: RO:0015016 PR:000001412
intersection_of: RO:0015016 PR:000001438
[Term]
id: CL:0002534
name: mature CD16-positive myeloid dendritic cell
def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." []
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0002532 ! CD16-positive myeloid dendritic cell
intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell
intersection_of: RO:0002104 PR:000001310
intersection_of: RO:0015015 GO:0042613
intersection_of: RO:0015015 PR:000001412
intersection_of: RO:0015015 PR:000001438
relationship: RO:0002202 CL:0002533 ! immature CD16-positive myeloid dendritic cell
[Term]
id: CL:0002535
name: epithelial cell of cervix
def: "An epithelial cell of the cervix." []
synonym: "cervical canal epithelial cell" EXACT []
synonym: "cervical canal of uterus epithelial cell" EXACT []
synonym: "cervix epithelial cell" EXACT []
synonym: "cervix of uterus epithelial cell" EXACT []
synonym: "epithelial cell of cervical canal" EXACT []
synonym: "epithelial cell of cervical canal of uterus" EXACT []
synonym: "epithelial cell of cervix of uterus" EXACT []
synonym: "epithelial cell of neck of uterus" EXACT []
synonym: "epithelial cell of uterine cervix" EXACT []
synonym: "neck of uterus epithelial cell" EXACT []
synonym: "uterine cervix epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000002
relationship: BFO:0000050 UBERON:0004801
[Term]
id: CL:0002539
name: aortic smooth muscle cell
def: "A smooth muscle cell of the aorta." []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0004178
[Term]
id: CL:0002540
name: mesenchymal stem cell of the bone marrow
def: "A mesenchymal stem cell that is part of the bone marrow." []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: BFO:0000050 UBERON:0002371
[Term]
id: CL:0002541
name: chorionic membrane mesenchymal stem cell
def: "A mesenchymal stem cell of the chorionic membrane." []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: BFO:0000050 UBERON:0003124
[Term]
id: CL:0002543
name: vein endothelial cell
def: "An endothelial cell that is part of the vein." []
synonym: "endothelial cell of vein" EXACT []
synonym: "venous endothelial cell" EXACT []
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0001638
[Term]
id: CL:0002546
name: embryonic blood vessel endothelial progenitor cell
def: "An endothelial progenitor cell that participates in angiogenesis during development." []
is_a: CL:0000222 ! mesodermal cell
[Term]
id: CL:0002548
name: fibroblast of cardiac tissue
def: "A fibroblast that is part of the heart." []
synonym: "cardiac fibroblast" EXACT []
is_a: CL:0000057 ! fibroblast
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0000948
[Term]
id: CL:0002553
name: fibroblast of lung
def: "A fibroblast that is part of lung." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002048
[Term]
id: CL:0002554
name: fibroblast of lymphatic vessel
def: "A fibroblast of the lymphatic system." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001473
[Term]
id: CL:0002555
name: fibroblast of mammary gland
def: "A fibroblast that is part of the mammary gland." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001911
[Term]
id: CL:0002557
name: fibroblast of pulmonary artery
def: "A fibroblast of pulmonary artery." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002012
[Term]
id: CL:0002559
name: hair follicle cell
def: "An animal cell that is part of a hair follicle." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002073
[Term]
id: CL:0002563
name: intestinal epithelial cell
def: "An epithelial cell of the intestine." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000160
relationship: BFO:0000050 UBERON:0001277
[Term]
id: CL:0002570
name: mesenchymal stem cell of adipose tissue
def: "A mesenchymal stem cell of adipose tissue." []
synonym: "mesenchymal stem cell of adipose" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: BFO:0000050 UBERON:0001013
[Term]
id: CL:0002571
name: hepatic mesenchymal stem cell
def: "A mesenchymal stem cell of liver." []
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002195 ! hepatic stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: BFO:0000050 UBERON:0002107
[Term]
id: CL:0002573
name: Schwann cell
def: "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." []
is_a: CL:0000125 ! glial cell
relationship: BFO:0000050 UBERON:0000010
[Term]
id: CL:0002574
name: stromal cell of pancreas
def: "A stromal cell of the pancreas." []
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0001264
[Term]
id: CL:0002575
name: central nervous system pericyte
def: "A pericyte of the central nervous system." []
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: BFO:0000050 UBERON:0001017
[Term]
id: CL:0002577
name: placental epithelial cell
def: "An epithelial cell of the placenta." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001987
[Term]
id: CL:0002584
name: renal cortical epithelial cell
def: "An epithelial cell of the kidney cortex." []
is_a: CL:0002518 ! kidney epithelial cell
is_a: CL:0002681 ! kidney cortical cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: BFO:0000050 UBERON:0001225
[Term]
id: CL:0002585
name: retinal blood vessel endothelial cell
def: "A blood vessel endothelial cell that is part of the retina." []
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0000966
[Term]
id: CL:0002586
name: retinal pigment epithelial cell
def: "An epithelial cell of the retinal pigmented epithelium." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000149 ! visual pigment cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001782
relationship: BFO:0000051 GO:0042470
[Term]
id: CL:0002590
name: smooth muscle cell of the brain vasculature
def: "A vascular associated smooth muscle cell of the brain vasculature." []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0000955
[Term]
id: CL:0002591
name: smooth muscle cell of the pulmonary artery
def: "A smooth muscle of the pulmonary artery." []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002012
[Term]
id: CL:0002592
name: smooth muscle cell of the coronary artery
def: "A smooth muscle cell of the coronary artery." []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001621
[Term]
id: CL:0002597
name: smooth muscle cell of bladder
def: "A smooth muscle cell of the bladder." []
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:1001319 ! bladder cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001255
[Term]
id: CL:0002598
name: bronchial smooth muscle cell
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002185
[Term]
id: CL:0002599
name: smooth muscle cell of the esophagus
def: "A smooth muscle cell of the esophagus." []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001043
[Term]
id: CL:0002601
name: uterine smooth muscle cell
def: "A smooth muscle cell of the uterus." []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0000995
[Term]
id: CL:0002603
name: astrocyte of the cerebellum
def: "An astrocyte of the cerebellum." []
is_a: CL:0000127 ! astrocyte
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0002037
[Term]
id: CL:0002604
name: hippocampal astrocyte
def: "An astrocyte that is part of the hippocampus." []
synonym: "astrocyte of the hippocampal formation" EXACT []
synonym: "astrocyte of the hippocampus" EXACT []
is_a: CL:0000127 ! astrocyte
is_a: CL:1001580 ! hippocampal glial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0002421
[Term]
id: CL:0002605
name: astrocyte of the cerebral cortex
def: "An astrocyte of the cerebral cortex." []
is_a: CL:0000127 ! astrocyte
is_a: CL:1001579 ! cerebral cortex glial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0000956
[Term]
id: CL:0002606
name: astrocyte of the spinal cord
def: "An astrocyte of the spinal cord." []
is_a: CL:0000127 ! astrocyte
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0002240
[Term]
id: CL:0002607
name: migratory enteric neural crest cell
def: "A neural crest cell that gives rise to cells of the enteric nervous system." []
is_a: CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0002608
name: hippocampal neuron
def: "A neuron with a soma found in the hippocampus." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002421
[Term]
id: CL:0002611
name: neuron of the dorsal spinal cord
def: "A CNS neuron of the dorsal spinal cord." []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: RO:0002100 UBERON:0002256
[Term]
id: CL:0002612
name: neuron of the ventral spinal cord
def: "A neuron of the ventral spinal cord." []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: RO:0002100 UBERON:0002257
[Term]
id: CL:0002613
name: striatum neuron
def: "A neuron of the striatum." []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: RO:0002100 UBERON:0002435
[Term]
id: CL:0002614
name: neuron of the substantia nigra
def: "A neuron of the substantia nigra." []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: RO:0002100 UBERON:0002038
[Term]
id: CL:0002620
name: skin fibroblast
def: "A fibroblast of skin." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002097
[Term]
id: CL:0002622
name: prostate stromal cell
def: "A stromal cell of the prostate." []
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0002367
[Term]
id: CL:0002623
name: acinar cell of salivary gland
def: "An acinar cell of salivary gland." []
is_a: CL:0000622 ! acinar cell
is_a: CL:1001596 ! salivary gland glandular cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: BFO:0000050 UBERON:0001044
[Term]
id: CL:0002625
name: seminiferous tubule epithelial cell
def: "A cell of the seminiferous tubule epithelium." []
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001343
relationship: BFO:0000050 UBERON:0004813
[Term]
id: CL:0002629
name: mature microglial cell
def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." []
synonym: "activated microglia" EXACT []
synonym: "mature microglia" EXACT []
synonym: "reactive microglia" EXACT []
is_a: CL:0000129 ! microglial cell
intersection_of: CL:0000129 ! microglial cell
intersection_of: RO:0002215 GO:0001816
intersection_of: RO:0002215 GO:0002536
intersection_of: RO:0002215 GO:0002537
intersection_of: RO:0002215 GO:0006909
intersection_of: RO:0002215 GO:0019882
[Term]
id: CL:0002630
name: actinomycete-type spore
def: "A spore formed from bacteria in the order Actinomycetales." []
is_a: CL:0000520 ! prokaryotic cell
[Term]
id: CL:0002632
name: epithelial cell of lower respiratory tract
is_a: CL:0002368 ! respiratory epithelial cell
intersection_of: CL:0002368 ! respiratory epithelial cell
intersection_of: BFO:0000050 UBERON:0001558
[Term]
id: CL:0002633
name: respiratory basal cell
def: "A basal cell in the respiratory tract." []
synonym: "airway basal cell" EXACT []
synonym: "airway basal stem cell" EXACT []
is_a: CL:0000646 ! basal cell
is_a: CL:0002368 ! respiratory epithelial cell
[Term]
id: CL:0002639
name: amniotic stem cell
def: "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" []
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002323 ! amniocyte
[Term]
id: CL:0002657
name: glandular cell of esophagus
def: "A glandular epithelial cell of the esophagus." []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002252 ! epithelial cell of esophagus
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001043
[Term]
id: CL:0002658
name: glandular cell of the large intestine
def: "A glandular epithelial cell of the large intestine." []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0000059
[Term]
id: CL:0002659
name: glandular cell of stomach
def: "A glandular epithelial cell that is part of the stomach." []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002178 ! epithelial cell of stomach
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0000945
[Term]
id: CL:0002664
name: cardioblast
def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." []
synonym: "cardiovascular progenitor cell" EXACT []
synonym: "CPC" RELATED []
is_a: CL:0000048 ! multi fate stem cell
[Term]
id: CL:0002671
name: endothelial stalk cell
def: "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." []
is_a: CL:0000071 ! blood vessel endothelial cell
[Term]
id: CL:0002672
name: retinal progenitor cell
def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." []
is_a: CL:0000048 ! multi fate stem cell
relationship: RO:0002202 CL:0000133 ! neurectodermal cell
[Term]
id: CL:0002673
name: tongue muscle cell
def: "A skeletal muscle cell that is part of the tongue." []
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: BFO:0000050 UBERON:0000378
[Term]
id: CL:0002676
name: neural crest derived neuroblast
def: "A neuroblast derived from a neural crest cell." []
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0002678
name: memory regulatory T cell
def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
is_a: CL:0000813 ! memory T cell
is_a: CL:0000815 ! regulatory T cell
is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell
intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
intersection_of: RO:0002353 GO:0043379
[Term]
id: CL:0002679
name: natural helper lymphocyte
def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: lacks_plasma_membrane_part GO:0042105
intersection_of: lacks_plasma_membrane_part PR:000001002
intersection_of: lacks_plasma_membrane_part PR:000001012
intersection_of: lacks_plasma_membrane_part PR:000001013
intersection_of: lacks_plasma_membrane_part PR:000001020
intersection_of: lacks_plasma_membrane_part PR:000001084
intersection_of: lacks_plasma_membrane_part PR:000001874
intersection_of: lacks_plasma_membrane_part PR:000002981
intersection_of: RO:0002104 PR:000002065
intersection_of: RO:0002104 PR:000002979
[Term]
id: CL:0002680
name: PP cell of intestine
def: "A PP cell found in intestine." []
is_a: CL:0000696 ! PP cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0000696 ! PP cell
intersection_of: BFO:0000050 UBERON:0000160
[Term]
id: CL:0002681
name: kidney cortical cell
def: "A cell that is part of a cortex of kidney." []
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: BFO:0000050 UBERON:0001225
[Term]
id: CL:0005000
name: spinal cord interneuron
def: "A CNS interneuron located in the spinal cord." []
is_a: CL:0000402 ! CNS interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002240
[Term]
id: CL:0005001
name: iridoblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005002
name: xanthoblast
def: "A non-terminally differentiated cell that differentiates into a xanthophore." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005003
name: leucoblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005004
name: pigment erythroblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005005
name: cyanoblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005006
name: ionocyte
def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." []
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0005012
name: multi-ciliated epithelial cell
def: "A ciliated epithelial cell with many cilia." []
synonym: "MCC" RELATED []
synonym: "multi-ciliated cell" BROAD []
synonym: "multiciliated cell" BROAD []
synonym: "multiciliated epithelial cell" EXACT []
is_a: CL:0000067 ! ciliated epithelial cell
relationship: BFO:0000051 GO:0005929
[Term]
id: CL:0005018
name: ghrelin secreting cell
def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0036321
[Term]
id: CL:0005019
name: pancreatic epsilon cell
def: "Ghrelin secreting cells found in the endocrine pancreas." []
synonym: "pancreatic E cell" EXACT []
is_a: CL:0005018 ! ghrelin secreting cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0008024 ! pancreatic endocrine cell
intersection_of: RO:0002215 GO:0036321
[Term]
id: CL:0005020
name: lymphangioblast
def: "Lymphatic progenitor cells." []
is_a: CL:0000048 ! multi fate stem cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: RO:0002220 UBERON:0004536
[Term]
id: CL:0005022
name: vascular lymphangioblast
def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." []
synonym: "parachordal lymphangioblast" NARROW []
is_a: CL:0005020 ! lymphangioblast
intersection_of: CL:0005020 ! lymphangioblast
intersection_of: RO:0002220 UBERON:0001638
[Term]
id: CL:0005024
name: somatomotor neuron
def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." []
synonym: "somatic motor neuron" EXACT []
is_a: CL:0000100 ! motor neuron
is_a: CL:0000108 ! cholinergic neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002120 CL:0008002 ! skeletal muscle fiber
relationship: RO:0002215 GO:0014055
[Term]
id: CL:0005026
name: hepatoblast
def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." []
is_a: CL:0000048 ! multi fate stem cell
[Term]
id: CL:0007000
name: preameloblast
def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." []
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: BFO:0000050 UBERON:0005176
relationship: RO:0002202 CL:0002077 ! ecto-epithelial cell
relationship: RO:0002220 UBERON:0001763
[Term]
id: CL:0007003
name: preodontoblast
def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: BFO:0000050 UBERON:0005176
relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell
[Term]
id: CL:0007004
name: premigratory neural crest cell
def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." []
is_a: CL:0011012 ! neural crest cell
relationship: BFO:0000050 UBERON:0002342
relationship: RO:0002202 CL:0000133 ! neurectodermal cell
[Term]
id: CL:0007005
name: notochordal cell
def: "Cell that is part of the notochord." []
is_a: CL:0000000 ! cell
relationship: BFO:0000050 UBERON:0002328
relationship: RO:0002202 CL:0007006 ! chordamesodermal cell
[Term]
id: CL:0007006
name: chordamesodermal cell
def: "Mesodermal cell that is axially located and gives rise to the cells of the notochord." []
synonym: "axial mesodermal cell" EXACT []
is_a: CL:0000222 ! mesodermal cell
relationship: BFO:0000050 UBERON:0004880
[Term]
id: CL:0007009
name: prechondroblast
def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." []
is_a: CL:0000055 ! non-terminally differentiated cell
[Term]
id: CL:0007010
name: preosteoblast
def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." []
synonym: "osteoprogenitor cell" EXACT []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0011026 ! progenitor cell
relationship: BFO:0000050 UBERON:0008883
relationship: RO:0002202 CL:0000222 ! mesodermal cell
relationship: RO:0002202 CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0007011
name: enteric neuron
def: "Neuron that is part of the enteric nervous system." []
is_a: CL:0000029 ! neural crest derived neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002005
relationship: BFO:0000050 UBERON:0002005
relationship: RO:0002202 CL:0002607 ! migratory enteric neural crest cell
[Term]
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." []
is_a: CL:0000187 ! muscle cell
[Term]
id: CL:0008001
name: hematopoietic precursor cell
def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." []
is_a: CL:0000988 ! hematopoietic cell
[Term]
id: CL:0008002
name: skeletal muscle fiber
def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." []
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0002372 ! myotube
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0001134
intersection_of: BFO:0000051 GO:0030017
intersection_of: RO:0000053 PATO:0001908
intersection_of: RO:0000053 PATO:0002478
relationship: RO:0002202 CL:0000515 ! skeletal muscle myoblast
[Term]
id: CL:0008003
name: somatic muscle myotube
def: "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." []
is_a: CL:0002372 ! myotube
is_a: CL:0008004 ! somatic muscle cell
intersection_of: CL:0008004 ! somatic muscle cell
intersection_of: BFO:0000051 GO:0030017
intersection_of: RO:0000053 PATO:0001908
intersection_of: RO:0000053 PATO:0002478
[Term]
id: CL:0008004
name: somatic muscle cell
def: "A muscle cell that is part of some somatic muscle." []
is_a: CL:0000187 ! muscle cell
[Term]
id: CL:0008007
name: visceral muscle cell
def: "A muscle cell that is part of some visceral muscle." []
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:8600004
[Term]
id: CL:0008008
name: striated visceral muscle cell
def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." []
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: RO:0000053 PATO:0001410 {all_some="true"}
[Term]
id: CL:0008009
name: transversely striated visceral muscle cell
def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." []
is_a: CL:0008007 ! visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: RO:0000053 PATO:0002478 {all_some="true"}
[Term]
id: CL:0008011
name: skeletal muscle satellite stem cell
def: "A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast." []
is_a: CL:0000035 ! single fate stem cell
is_a: CL:0000594 ! skeletal muscle satellite cell
intersection_of: CL:0000594 ! skeletal muscle satellite cell
intersection_of: RO:0000053 PATO:0001400
intersection_of: RO:0002215 GO:0017145
[Term]
id: CL:0008012
name: quiescent skeletal muscle satellite cell
def: "A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage." []
is_a: CL:0000594 ! skeletal muscle satellite cell
[Term]
id: CL:0008016
name: activated skeletal muscle satellite cell
def: "A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage." []
is_a: CL:0000594 ! skeletal muscle satellite cell
relationship: RO:0002202 CL:0008012 ! quiescent skeletal muscle satellite cell
[Term]
id: CL:0008017
name: adult skeletal muscle myoblast
def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." []
synonym: "myogenic precursor cell" BROAD []
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: BFO:0000050 UBERON:0001134
intersection_of: RO:0002203 CL:0008002 ! skeletal muscle fiber
[Term]
id: CL:0008018
name: somatic muscle myoblast
def: "A myoblast that is commited to developing into a somatic muscle." []
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0008003 ! somatic muscle myotube
[Term]
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000000 ! cell
relationship: BFO:0000050 UBERON:0003104
relationship: RO:0002215 GO:0016477
[Term]
id: CL:0008021
name: anterior lateral line ganglion neuron
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:2001391
[Term]
id: CL:0008022
name: endocardial cushion cell
def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." []
is_a: CL:0000569 ! cardiac mesenchymal cell
intersection_of: CL:0000569 ! cardiac mesenchymal cell
intersection_of: BFO:0000050 UBERON:0002062
[Term]
id: CL:0008024
name: pancreatic endocrine cell
def: "An endocrine cell that is part of the pancreas." []
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000164 ! enteroendocrine cell
intersection_of: CL:0000163 ! endocrine cell
intersection_of: BFO:0000050 UBERON:0001264
[Term]
id: CL:0008025
name: noradrenergic neuron
def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061533
[Term]
id: CL:0008026
name: open tracheal system tracheocyte
def: "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0003127
[Term]
id: CL:0008028
name: visual system neuron
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002216 GO:0007601
[Term]
id: CL:0008031
name: cortical interneuron
def: "An interneuron that has its soma located in the cerebral cortex." []
synonym: "cerebral cortex interneuron" EXACT []
is_a: CL:0000099 ! interneuron
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000956
[Term]
id: CL:0008033
name: decidual pericyte
def: "A pericyte of the decidual vasculature." []
synonym: "decidual perivascular cell" EXACT []
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: BFO:0000050 UBERON:0002450
[Term]
id: CL:0008034
name: mural cell
def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." []
is_a: CL:4033054 ! perivascular cell
[Term]
id: CL:0008038
name: alpha motor neuron
def: "A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS." []
synonym: "alpha motoneuron" EXACT []
is_a: CL:0008039 ! lower motor neuron
relationship: RO:0002120 CL:0008046 ! extrafusal muscle fiber
[Term]
id: CL:0008039
name: lower motor neuron
def: "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." []
is_a: CL:0005024 ! somatomotor neuron
relationship: RO:0002120 CL:0008002 ! skeletal muscle fiber
relationship: RO:0002162 NCBITaxon:7742
[Term]
id: CL:0008046
name: extrafusal muscle fiber
def: "A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons." []
synonym: "myofibra extrafusalis" EXACT []
is_a: CL:0008002 ! skeletal muscle fiber
relationship: RO:0002103 CL:0008038 ! alpha motor neuron
[Term]
id: CL:0009001
name: compound eye retinal cell
def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0009004
name: retinal cell
def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." []
is_a: CL:0002319 ! neural cell
intersection_of: CL:0002319 ! neural cell
intersection_of: BFO:0000050 UBERON:0005388
[Term]
id: CL:0009006
name: enteroendocrine cell of small intestine
def: "An enteroendocrine cell that is located in the small intestine." []
synonym: "small intestine enteroendocrine cell" EXACT []
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0002108
[Term]
id: CL:0009014
name: Peyer's patch lymphocyte
def: "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." []
synonym: "Peyer's patch resident lymphocyte" EXACT []
synonym: "small intestine Peyer's patch lymphocyte" NARROW []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: BFO:0000050 UBERON:0001211
[Term]
id: CL:0009015
name: Peyer's patch follicular dendritic cell
def: "A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside." []
is_a: CL:0000442 ! follicular dendritic cell
intersection_of: CL:0000442 ! follicular dendritic cell
intersection_of: BFO:0000050 UBERON:0001211
[Term]
id: CL:0009024
name: mesothelial cell of small intestine
def: "A mesothelial cell that is part of the small intestine." []
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002108
[Term]
id: CL:0009025
name: mesothelial cell of colon
def: "A mesothelial cell that is part of the colon." []
synonym: "mesothelial cell of large intestine" BROAD []
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0001155
[Term]
id: CL:0009038
name: colon macrophage
def: "A macrophage that is located in the colon." []
synonym: "macrophage of colon" EXACT []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: BFO:0000050 UBERON:0001155
[Term]
id: CL:0009039
name: colon goblet cell
def: "A goblet cell that is located in the colon." []
synonym: "goblet cell of colon" EXACT []
is_a: CL:0000160 ! goblet cell
is_a: CL:1001588 ! colon glandular cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0001155
[Term]
id: CL:0009042
name: enteroendocrine cell of colon
def: "An enteroendocrine cell that is located in the colon." []
synonym: "colon enteroendocrine cell" EXACT []
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:1001588 ! colon glandular cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: BFO:0000050 UBERON:0001155
[Term]
id: CL:0009084
name: epithelial cell of endometrial gland
def: "An epithelial cell that is part of an endometrial gland." []
synonym: "endometrial glandular epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002451
[Term]
id: CL:0009089
name: lung pericyte
def: "A pericyte cell that is part of a lung." []
synonym: "lung pericyte cell" EXACT []
synonym: "pulmonary pericyte" EXACT []
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: BFO:0000050 UBERON:0002048
[Term]
id: CL:0009091
name: Leydig stem cell
def: "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." []
synonym: "stem Leydig cell" EXACT []
is_a: CL:0000034 ! stem cell
relationship: BFO:0000050 UBERON:0005212
[Term]
id: CL:0009092
name: endothelial cell of placenta
def: "An endothelial cell that is part of a placenta." []
synonym: "placental endothelial cell" EXACT []
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002577 ! placental epithelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001987
[Term]
id: CL:0009093
name: smooth muscle cell of placenta
def: "A smooth muscle cell that is part of a placenta." []
synonym: "placental smooth muscle cell" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001987
[Term]
id: CL:0009095
name: endothelial cell of uterus
def: "An endothelial cell that is part of a uterus." []
synonym: "uterine endothelial cell" EXACT []
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000995
[Term]
id: CL:0009115
name: lymph node lymphatic vessel endothelial cell
def: "An endothelial cell located in a lymph node lymphatic vessel." []
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000029
intersection_of: BFO:0000050 UBERON:0001473
[Term]
id: CL:0009116
name: progenitor cell of mammary luminal epithelium
def: "A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells." []
synonym: "luminal progenitor cell" BROAD []
synonym: "progenitor cell of luminal mammary epithelium" EXACT []
is_a: CL:0011026 ! progenitor cell
relationship: BFO:0000050 UBERON:0001911
[Term]
id: CL:0010001
name: stromal cell of bone marrow
def: "A stromal cell that is part_of a bone marrow." []
synonym: "bone marrow stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0002371
[Term]
id: CL:0010003
name: epithelial cell of alveolus of lung
def: "An epithelial cell that is part_of a alveolus of lung." []
synonym: "alveolus of lung epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002299
[Term]
id: CL:0010004
name: mononuclear cell of bone marrow
def: "A mononuclear cell that is part_of a bone marrow." []
synonym: "bone marrow mononuclear cell" EXACT []
is_a: CL:0000842 ! mononuclear cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: BFO:0000050 UBERON:0002371
[Term]
id: CL:0010005
name: atrioventricular bundle cell
def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." []
synonym: "AV bundle cell" EXACT []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002353
[Term]
id: CL:0010006
name: cardiac blood vessel endothelial cell
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0000948
[Term]
id: CL:0010007
name: His-Purkinje system cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0004146
[Term]
id: CL:0010008
name: cardiac endothelial cell
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000948
[Term]
id: CL:0010009
name: camera-type eye photoreceptor cell
synonym: "camera type eye photoreceptor cell" EXACT []
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: BFO:0000050 UBERON:0000019
[Term]
id: CL:0010010
name: cerebellar stellate cell
is_a: CL:0000122 ! stellate neuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000122 ! stellate neuron
intersection_of: RO:0002100 UBERON:0002037
[Term]
id: CL:0010011
name: cerebral cortex GABAergic interneuron
def: "A GABAergic interneuron whose soma is located in the cerebral cortex." []
is_a: CL:0008031 ! cortical interneuron
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: RO:0002100 UBERON:0000956
[Term]
id: CL:0010012
name: cerebral cortex neuron
def: "A CNS neuron of the cerebral cortex." []
synonym: "cortical neuron" EXACT []
synonym: "neuron of cerebral cortex" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000956
[Term]
id: CL:0010017
name: zygote
def: "A zygote in a plant or an animal." []
is_a: CL:0000000 ! cell
[Term]
id: CL:0010020
name: cardiac glial cell
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0000948
[Term]
id: CL:0010021
name: cardiac myoblast
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0000746 ! cardiac muscle cell
[Term]
id: CL:0010022
name: cardiac neuron
def: "A neuron that has its soma in the heart." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000948
[Term]
id: CL:0011000
name: dorsal horn interneuron
def: "A CNS interneuron located in the dorsal horn of the spinal cord." []
synonym: "dorsal spinal cord interneuron" RELATED []
is_a: CL:0005000 ! spinal cord interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002256
[Term]
id: CL:0011001
name: spinal cord motor neuron
def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." []
is_a: CL:0000100 ! motor neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002100 UBERON:0002240
[Term]
id: CL:0011002
name: lateral motor column neuron
def: "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." []
is_a: CL:0011001 ! spinal cord motor neuron
[Term]
id: CL:0011004
name: lens fiber cell
def: "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." []
synonym: "lens fibre cell" EXACT []
is_a: CL:0002222 ! vertebrate lens cell
[Term]
id: CL:0011005
name: GABAergic interneuron
def: "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" []
synonym: "GABAergic inhibitory interneuron" EXACT []
is_a: CL:0000498 ! inhibitory interneuron
is_a: CL:0000617 ! GABAergic neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002215 GO:0061534
[Term]
id: CL:0011006
name: Lugaro cell
def: "An inhibitory GABAergic interneuron found in the cerebellar cortex." []
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
relationship: RO:0002100 UBERON:0002129
[Term]
id: CL:0011008
name: embryonic hemocyte
def: "A hemocyte derived from the embryonic head mesoderm, which enters the hemolymph as a circulating cell." []
is_a: CL:0000387 ! hemocyte (sensu Arthropoda)
[Term]
id: CL:0011012
name: neural crest cell
def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." []
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002321 ! embryonic cell (metazoa)
[Term]
id: CL:0011013
name: motile sperm cell
def: "A sperm cell that is cabaple of motion (motility)." []
is_a: CL:0000019 ! sperm
intersection_of: CL:0000019 ! sperm
intersection_of: RO:0002215 GO:0097722
[Term]
id: CL:0011014
name: non-motile sperm cell
def: "A sperm cell that is not cabaple of motion (motility)." []
is_a: CL:0000019 ! sperm
[Term]
id: CL:0011015
name: amoeboid sperm cell
def: "A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system." []
is_a: CL:0011013 ! motile sperm cell
[Term]
id: CL:0011016
name: flagellated sperm cell
def: "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." []
is_a: CL:0011013 ! motile sperm cell
intersection_of: CL:0011013 ! motile sperm cell
intersection_of: RO:0002215 GO:0030317
[Term]
id: CL:0011019
name: mesothelial cell of epicardium
def: "A mesothelial cell that is part of the epicardium." []
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002348
[Term]
id: CL:0011020
name: neural progenitor cell
def: "An undifferentiated cell that originates from a neural stem cell and has the capacity to generate multiple types of lineage-restricted progenitors but not to self-renew." []
is_a: CL:0000055 ! non-terminally differentiated cell
[Term]
id: CL:0011024
name: double negative T regulatory cell
def: "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." []
synonym: "CD4-negative, CD8-negative, alpha-beta regulatory T cells" EXACT []
synonym: "DN Treg" EXACT []
synonym: "double-negative alpha-beta regulatory T cell" EXACT []
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0002489 ! double negative thymocyte
intersection_of: RO:0002215 GO:0050777
[Term]
id: CL:0011025
name: exhausted T cell
synonym: "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential." EXACT []
synonym: "Tex cell" EXACT []
is_a: CL:0000911 ! effector T cell
[Term]
id: CL:0011026
name: progenitor cell
def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." []
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: RO:0002202 CL:0000034 ! stem cell
[Term]
id: CL:0011027
name: skeletal muscle fibroblast
def: "Any fibroblast that is part of skeletal muscle tissue." []
synonym: "skeleton muscle fibroblast" EXACT []
is_a: CL:0000057 ! fibroblast
is_a: CL:0000188 ! cell of skeletal muscle
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001134
[Term]
id: CL:0011101
name: chorionic trophoblast cell
def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." []
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: BFO:0000050 UBERON:0003124
[Term]
id: CL:0011103
name: sympathetic neuron
def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." []
is_a: CL:0000107 ! autonomic neuron
[Term]
id: CL:0011108
name: colon epithelial cell
def: "Epithelial cell that is part of the colon epithelium." []
synonym: "colonic epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001155
relationship: BFO:0000050 UBERON:0000397
[Term]
id: CL:0011109
name: hypocretin-secreting neuron
def: "A neuron that releases hypocretin as a neurotransmitter." []
synonym: "orexin" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061585
[Term]
id: CL:0011110
name: histaminergic neuron
def: "Neuron that secretes histamine." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061538
[Term]
id: CL:0011115
name: precursor cell
def: "A cell that, by division or terminal differentiation, can give rise to other cell types." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0030154
[Term]
id: CL:0012000
name: astrocyte of the forebrain
def: "An astrocyte of the forebrain." []
synonym: "forebrain astrocyte" EXACT []
is_a: CL:0000127 ! astrocyte
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0001890
[Term]
id: CL:0012001
name: neuron of the forebrain
def: "A CNS neuron of the forebrain." []
synonym: "forebrain neuron" EXACT []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: RO:0002100 UBERON:0001890
[Term]
id: CL:0013000
name: forebrain radial glial cell
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: BFO:0000050 UBERON:0001890
[Term]
id: CL:0017002
name: prostate neuroendocrine cell
def: "A neuroendocrine cell that is part of the prostate epithelium." []
synonym: "neuroendocrine cell of prostate epithelium" EXACT []
synonym: "neuroendocrine cell of the prostate" EXACT []
is_a: CL:0000165 ! neuroendocrine cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: BFO:0000050 UBERON:0000428
[Term]
id: CL:0017500
name: neutrophillic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." []
is_a: GO:0005737
intersection_of: GO:0005737
intersection_of: RO:0000053 PATO:0070046
[Term]
id: CL:0017502
name: acidophilic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." []
synonym: "eosinophilic" NARROW []
is_a: GO:0005737
intersection_of: GO:0005737
intersection_of: RO:0000053 PATO:0002418
[Term]
id: CL:0017503
name: basophilic cytoplasm
def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." []
is_a: GO:0005737
intersection_of: GO:0005737
intersection_of: RO:0000053 PATO:0002094
[Term]
id: CL:0017504
name: polychromatophilic cytoplasm
def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." []
is_a: GO:0005737
intersection_of: GO:0005737
intersection_of: RO:0000053 PATO:0070047
[Term]
id: CL:0017506
name: banded nucleus
def: "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." []
is_a: GO:0005634
[Term]
id: CL:0017507
name: reniform nucleus
def: "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." []
is_a: GO:0005634
intersection_of: GO:0005634
intersection_of: RO:0000053 PATO:0001871
[Term]
id: CL:0017508
name: cartwheel heterochromatin
def: "Heterochromatin that is arranged in a carthwheel pattern." []
is_a: GO:0000792
[Term]
id: CL:0017509
name: alobate nucleus
is_a: GO:0005634
intersection_of: GO:0005634
intersection_of: RO:0000053 PATO:0002506
[Term]
id: CL:0019002
name: tracheobronchial chondrocyte
def: "Any chondrocyte that is part of the tracheobronchial tree." []
synonym: "chondrocyte of tracheobronchial tree" EXACT []
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: BFO:0000050 UBERON:0007196
[Term]
id: CL:0019003
name: tracheobronchial goblet cell
def: "Any goblet cell that is part of the tracheobronchial epithelium." []
synonym: "goblet cell of tracheobronchial tree" EXACT []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0002370 ! respiratory goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0007196
[Term]
id: CL:0019017
name: lymphatic vessel smooth muscle cell
def: "A smooth muscle cell that is part of any lymphatic vessel." []
synonym: "smooth muscle cell of lymphatic vessel" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001473
[Term]
id: CL:0019018
name: blood vessel smooth muscle cell
def: "A smooth muscle cell that is part of any blood vessel." []
synonym: "smooth muscle cell of blood vessel" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001981
[Term]
id: CL:0019019
name: tracheobronchial smooth muscle cell
def: "A smooth muscle cell that is part of the tracheobronchial tree." []
synonym: "smooth muscle cell of tracheobronchial tree" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0007196
[Term]
id: CL:0019031
name: intestine goblet cell
def: "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." []
synonym: "intestinal goblet cell" EXACT []
is_a: CL:0000160 ! goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0001277
[Term]
id: CL:1000001
name: retrotrapezoid nucleus neuron
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0009918
[Term]
id: CL:1000022
name: mesonephric nephron tubule epithelial cell
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005329
[Term]
id: CL:1000042
name: forebrain neuroblast
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata)
intersection_of: BFO:0000050 UBERON:0001890
[Term]
id: CL:1000050
name: lateral line nerve glial cell
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0008906
[Term]
id: CL:1000073
name: spinal cord radial glial cell
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: BFO:0000050 UBERON:0002240
[Term]
id: CL:1000090
name: pronephric nephron tubule epithelial cell
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005310
[Term]
id: CL:1000123
name: metanephric nephron tubule epithelial cell
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005146
[Term]
id: CL:1000143
name: lung goblet cell
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0000160 ! goblet cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0002048
[Term]
id: CL:1000147
name: cardiac valve cell
def: "A cell that is part of a cardiac valve." []
synonym: "heart valve cell" EXACT []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000946
[Term]
id: CL:1000155
name: Malpighian tubule stellate cell
def: "A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." []
synonym: "Malpighian tubule Type II cell" EXACT []
is_a: CL:0000151 ! secretory cell
relationship: BFO:0000050 UBERON:0001054
[Term]
id: CL:1000182
name: malpighian tubule tip cell
is_a: CL:0000423 ! tip cell
intersection_of: CL:0000423 ! tip cell
intersection_of: BFO:0000050 UBERON:0001054
[Term]
id: CL:1000217
name: growth plate cartilage chondrocyte
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: BFO:0000050 UBERON:0004129
[Term]
id: CL:1000222
name: stomach neuroendocrine cell
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: BFO:0000050 UBERON:0000945
[Term]
id: CL:1000223
name: lung neuroendocrine cell
def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." []
synonym: "PNEC" RELATED []
synonym: "pulmonary neuroendocrine cell" EXACT []
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0000206 ! chemoreceptor cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: BFO:0000050 UBERON:0002048
relationship: BFO:0000051 GO:0031045
relationship: RO:0002215 GO:0001820
relationship: RO:0002215 GO:0070483
[Term]
id: CL:1000236
name: posterior lateral line nerve glial cell
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:2000175
[Term]
id: CL:1000239
name: anterior lateral line nerve glial cell
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:2000425
[Term]
id: CL:1000245
name: posterior lateral line ganglion neuron
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:2001314
[Term]
id: CL:1000271
name: lung ciliated cell
is_a: CL:4030034 ! respiratory ciliated cell
intersection_of: CL:0000064 ! ciliated cell
intersection_of: BFO:0000050 UBERON:0002048
[Term]
id: CL:1000272
name: lung secretory cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0002048
[Term]
id: CL:1000274
name: trophectodermal cell
synonym: "trophectoderm cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell
[Term]
id: CL:1000275
name: smooth muscle cell of small intestine
def: "A smooth muscle cell that is part of the small intestine." []
synonym: "non-striated muscle fiber of small intestine" EXACT []
is_a: CL:0002504 ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002108
[Term]
id: CL:1000279
name: smooth muscle cell of large intestine
def: "A smooth muscle cell that is part of the large intestine." []
synonym: "non-striated muscle fiber of large intestine" EXACT []
is_a: CL:0002504 ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: BFO:0000050 UBERON:0000059
[Term]
id: CL:1000280
name: smooth muscle cell of colon
def: "A smooth muscle cell that is part of the colon." []
synonym: "non-striated muscle fiber of colon" EXACT []
is_a: CL:0002504 ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001155
[Term]
id: CL:1000281
name: smooth muscle cell of cecum
def: "A smooth muscle cell that is part of the cecum." []
synonym: "non-striated muscle fiber of cecum" EXACT []
synonym: "smooth muscle fiber of cecum" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001153
[Term]
id: CL:1000296
name: epithelial cell of urethra
def: "An epithelial cell that is part of the urethra." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:1001320 ! urethra cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000057
[Term]
id: CL:1000312
name: bronchial goblet cell
def: "A goblet cell that is part of the epithelium of bronchus." []
synonym: "goblet cell of epithelium of bronchus" EXACT []
is_a: CL:0000160 ! goblet cell
is_a: CL:0002328 ! bronchial epithelial cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0002185
relationship: BFO:0000050 UBERON:0002031
[Term]
id: CL:1000313
name: gastric goblet cell
def: "A goblet cell that is part of the epithelium of stomach." []
synonym: "goblet cell of epithelium of stomach" EXACT []
is_a: CL:0000160 ! goblet cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0000945
relationship: BFO:0000050 UBERON:0001276
[Term]
id: CL:1000320
name: large intestine goblet cell
def: "A goblet cell that is part of the epithelium of large intestine." []
synonym: "goblet cell of epithelium of large intestine" EXACT []
is_a: CL:0000160 ! goblet cell
is_a: CL:0002658 ! glandular cell of the large intestine
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0000059
relationship: BFO:0000050 UBERON:0001278
[Term]
id: CL:1000322
name: pancreatic goblet cell
def: "A goblet cell that is part of the epithelium of pancreatic duct." []
synonym: "goblet cell of epithelium of pancreatic duct" EXACT []
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000160 ! goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0001264
relationship: BFO:0000050 UBERON:0009970
[Term]
id: CL:1000334
name: enterocyte of epithelium of small intestine
def: "An enterocyte that is part of the epithelium of small intestine." []
is_a: CL:0000584 ! enterocyte
intersection_of: CL:0000584 ! enterocyte
intersection_of: BFO:0000050 UBERON:0001902
[Term]
id: CL:1000347
name: enterocyte of colon
def: "A columnar cell of the colon that is part of the colonic epithelium." []
synonym: "vacuolar absorptive cell of epithelium of colon" NARROW []
is_a: CL:0002071 ! enterocyte of epithelium of large intestine
intersection_of: CL:0002071 ! enterocyte of epithelium of large intestine
intersection_of: BFO:0000050 UBERON:0000397
[Term]
id: CL:1000349
name: basal cell of epithelium of bronchus
def: "A basal cell found in the bronchus epithelium." []
synonym: "basal cell of bronchus" EXACT []
is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree
is_a: CL:0002633 ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: BFO:0000050 UBERON:0002031
[Term]
id: CL:1000376
name: Purkinje myocyte of interventricular septum
def: "A Purkinje myocyte that is part of the interventricular septum." []
is_a: CL:0002068 ! Purkinje myocyte
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: BFO:0000050 UBERON:0002094
[Term]
id: CL:1000391
name: melanocyte of eyelid
def: "A melanocyte that is part of the eyelid." []
synonym: "eyelid melanocyte" EXACT []
synonym: "sebaceous gland of wolff" EXACT []
is_a: CL:0000148 ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: BFO:0000050 UBERON:0001711
[Term]
id: CL:1000409
name: myocyte of sinoatrial node
def: "A muscle cell that is part of the sinoatrial node." []
synonym: "SA nodal myocyte" EXACT []
synonym: "SA node cardiac muscle cell" EXACT []
synonym: "sinoatrial node cell" EXACT []
synonym: "sinoatrial node myocyte" EXACT []
synonym: "sinuatrial node myocyte" EXACT []
is_a: CL:0002072 ! nodal myocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0002351
[Term]
id: CL:1000410
name: myocyte of atrioventricular node
def: "A muscle cell that is part of the atrioventricular node." []
synonym: "atrioventricular node cell" EXACT []
synonym: "atrioventricular node myocyte" EXACT []
synonym: "AV nodal myocyte" EXACT []
synonym: "AV node cardiac muscle cell" EXACT []
synonym: "AV node cell" EXACT []
is_a: CL:0002072 ! nodal myocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0002352
[Term]
id: CL:1000413
name: endothelial cell of artery
def: "A blood vessel endothelial cell that is part of an arterial endothelium." []
synonym: "arterial endothelial cell" EXACT []
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001637
relationship: BFO:0000050 UBERON:0001917
[Term]
id: CL:1000415
name: epithelial cell of gallbladder
def: "An epithelial cell that is part of the gallbladder." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002110
[Term]
id: CL:1000426
name: chromaffin cell of adrenal gland
def: "A chromaffin cell that is part of the adrenal gland." []
synonym: "adrenal chromaffin cell" EXACT []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000166 ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0002369
[Term]
id: CL:1000427
name: adrenal cortex chromaffin cell
def: "A chromaffin cell that is part of the adrenal cortex." []
synonym: "chromaffin cell of adrenal cortex" EXACT []
is_a: CL:0000166 ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0001235
[Term]
id: CL:1000428
name: stem cell of epidermis
def: "A somatic stem cell that is part of the epidermis." []
synonym: "epidermal stem cell" EXACT []
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000723 ! somatic stem cell
intersection_of: BFO:0000050 UBERON:0001003
[Term]
id: CL:1000443
name: ciliary muscle cell
def: "A smooth muscle cell that is part of the ciliary body." []
synonym: "smooth muscle cell of ciliary body" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001775
[Term]
id: CL:1000448
name: epithelial cell of sweat gland
def: "An epithelial cell that is part of the sweat gland." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001820
[Term]
id: CL:1000449
name: epithelial cell of nephron
def: "An epithelial cell that is part of the nephron." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001285
[Term]
id: CL:1000450
name: epithelial cell of glomerular capsule
def: "An epithelial cell that is part of the glomerular capsule." []
synonym: "Bowmans capsule epithelial cell" EXACT []
synonym: "epithelial cell of Bowman's capsule" EXACT []
is_a: CL:1000510 ! kidney glomerular epithelial cell
is_a: CL:1000612 ! kidney corpuscule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001230
[Term]
id: CL:1000454
name: kidney collecting duct epithelial cell
def: "An epithelial cell that is part of the collecting duct of renal tubule." []
synonym: "epithelial cell of renal collecting tubule" EXACT []
is_a: CL:0000072 ! non-branched duct epithelial cell
is_a: CL:0002518 ! kidney epithelial cell
is_a: CL:1001225 ! kidney collecting duct cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001232
[Term]
id: CL:1000456
name: mesothelial cell of parietal peritoneum
def: "A mesothelial cell that is part of the parietal peritoneum." []
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0001366
[Term]
id: CL:1000457
name: mesothelial cell of visceral peritoneum
def: "A mesothelial cell that is part of the visceral peritoneum." []
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0001178
[Term]
id: CL:1000458
name: melanocyte of skin
def: "A melanocyte that is part of the skin of body." []
synonym: "skin melanocyte" EXACT []
is_a: CL:0000148 ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: BFO:0000050 UBERON:0002097
[Term]
id: CL:1000465
name: chromaffin cell of ovary
def: "A chromaffin cell that is part of the ovary." []
is_a: CL:0000166 ! chromaffin cell
is_a: CL:2000064 ! ovarian surface epithelial cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0000992
[Term]
id: CL:1000479
name: Purkinje myocyte of atrioventricular node
def: "A Purkinje myocyte that is part of the atrioventricular node." []
is_a: CL:0002068 ! Purkinje myocyte
is_a: CL:1000410 ! myocyte of atrioventricular node
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: BFO:0000050 UBERON:0002352
[Term]
id: CL:1000484
name: Purkinje myocyte of atrioventricular bundle
def: "A Purkinje myocyte that is part of the atrioventricular bundle." []
is_a: CL:0002068 ! Purkinje myocyte
is_a: CL:0010005 ! atrioventricular bundle cell
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: BFO:0000050 UBERON:0002353
[Term]
id: CL:1000486
name: basal cell of urothelium
def: "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role." []
synonym: "urothelial basal cell" EXACT []
is_a: CL:0000646 ! basal cell
is_a: CL:0000731 ! urothelial cell
intersection_of: CL:0000646 ! basal cell
intersection_of: BFO:0000050 UBERON:0000365
[Term]
id: CL:1000487
name: smooth muscle cell of prostate
def: "A smooth muscle cell that is part of the prostate gland." []
synonym: "smooth muscle fiber of prostate" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002367
[Term]
id: CL:1000488
name: cholangiocyte
def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." []
synonym: "epithelial cell of bile duct" EXACT []
is_a: CL:0000069 ! branched duct epithelial cell
intersection_of: CL:0000069 ! branched duct epithelial cell
intersection_of: BFO:0000050 UBERON:0002394
intersection_of: RO:0002215 GO:0015106
relationship: RO:0002202 CL:0005026 ! hepatoblast
[Term]
id: CL:1000490
name: mesothelial cell of peritoneum
def: "A mesothelial cell that is part of the peritoneum." []
synonym: "peritoneal mesothelial cell" EXACT []
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002358
[Term]
id: CL:1000494
name: nephron tubule epithelial cell
def: "An epithelial cell that is part of a nephron tubule." []
synonym: "kidney tubule epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004810
[Term]
id: CL:1000495
name: small intestine goblet cell
def: "A goblet cell that is part of the small intestine." []
synonym: "goblet cell of epithelium of small intestine" EXACT []
synonym: "goblet cell of small intestine" EXACT []
synonym: "small intestinal goblet cell" EXACT []
is_a: CL:0000160 ! goblet cell
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0002108
relationship: BFO:0000050 UBERON:0001902
[Term]
id: CL:1000497
name: kidney cell
def: "A cell that is part of a kidney." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002113
[Term]
id: CL:1000500
name: kidney interstitial cell
def: "A cell that is part of kidney interstitium." []
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: BFO:0000050 UBERON:0005215
[Term]
id: CL:1000504
name: kidney medulla cell
def: "A cell that is part of a renal medulla." []
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: BFO:0000050 UBERON:0000362
[Term]
id: CL:1000507
name: kidney tubule cell
def: "A cell that is part of a nephron tubule." []
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: BFO:0000050 UBERON:0001231
[Term]
id: CL:1000510
name: kidney glomerular epithelial cell
is_a: CL:0002518 ! kidney epithelial cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: BFO:0000050 UBERON:0004188
relationship: BFO:0000050 UBERON:0004188
[Term]
id: CL:1000546
name: kidney medulla collecting duct epithelial cell
def: "An epithelial cell that is part of a renal medulla collecting duct." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005185
[Term]
id: CL:1000547
name: kidney inner medulla collecting duct epithelial cell
def: "An epithelial cell that is part of some inner medullary collecting duct." []
is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004205
[Term]
id: CL:1000548
name: kidney outer medulla collecting duct epithelial cell
def: "An epithelial cell that is part of an outer medullary collecting duct." []
is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004204
[Term]
id: CL:1000549
name: kidney cortex collecting duct epithelial cell
def: "An epithelial cell that is part of a cortical collecting duct." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004203
[Term]
id: CL:1000601
name: ureteral cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000056
relationship: BFO:0000050 UBERON:0000056
[Term]
id: CL:1000606
name: kidney nerve cell
is_a: CL:1000500 ! kidney interstitial cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002113
[Term]
id: CL:1000612
name: kidney corpuscule cell
is_a: CL:0002584 ! renal cortical epithelial cell
intersection_of: CL:0002584 ! renal cortical epithelial cell
intersection_of: BFO:0000050 UBERON:0001229
relationship: BFO:0000050 UBERON:0001229
[Term]
id: CL:1000615
name: kidney cortex tubule cell
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:1000507 ! kidney tubule cell
intersection_of: BFO:0000050 UBERON:0006853
relationship: BFO:0000050 UBERON:0006853
[Term]
id: CL:1000616
name: kidney outer medulla cell
is_a: CL:1000504 ! kidney medulla cell
intersection_of: CL:1000504 ! kidney medulla cell
intersection_of: BFO:0000050 UBERON:0001293
relationship: BFO:0000050 UBERON:0001293
[Term]
id: CL:1000617
name: kidney inner medulla cell
is_a: CL:1000504 ! kidney medulla cell
intersection_of: CL:1000504 ! kidney medulla cell
intersection_of: BFO:0000050 UBERON:0001294
relationship: BFO:0000050 UBERON:0001294
[Term]
id: CL:1000618
name: juxtaglomerular complex cell
synonym: "juxtaglomerulus cell" EXACT []
is_a: CL:0002681 ! kidney cortical cell
intersection_of: CL:0002681 ! kidney cortical cell
intersection_of: BFO:0000050 UBERON:0002303
relationship: BFO:0000050 UBERON:0002303
[Term]
id: CL:1000692
name: kidney interstitial fibroblast
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0005215
[Term]
id: CL:1000706
name: ureter urothelial cell
is_a: CL:0000731 ! urothelial cell
is_a: CL:1000601 ! ureteral cell
intersection_of: CL:0000731 ! urothelial cell
intersection_of: BFO:0000050 UBERON:0001254
relationship: BFO:0000050 UBERON:0001254
[Term]
id: CL:1000742
name: glomerular mesangial cell
def: "A mesangial cell located among the glomerular capillaries in a renal corpuscle." []
synonym: "intraglomerular mesangial cell" EXACT []
is_a: CL:0000234 ! phagocyte
is_a: CL:0000650 ! mesangial cell
is_a: CL:1000612 ! kidney corpuscule cell
relationship: BFO:0000050 UBERON:0002320
relationship: RO:0002215 GO:0006909
relationship: RO:0002215 GO:0070252
[Term]
id: CL:1000746
name: glomerular cell
is_a: CL:1000612 ! kidney corpuscule cell
intersection_of: CL:1000612 ! kidney corpuscule cell
intersection_of: BFO:0000050 UBERON:0000074
relationship: BFO:0000050 UBERON:0000074
[Term]
id: CL:1000768
name: kidney connecting tubule epithelial cell
is_a: CL:1000494 ! nephron tubule epithelial cell
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: BFO:0000050 UBERON:0005097
relationship: BFO:0000050 UBERON:0005097
[Term]
id: CL:1000838
name: kidney proximal convoluted tubule epithelial cell
is_a: CL:0002306 ! epithelial cell of proximal tubule
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: BFO:0000050 UBERON:0001287
relationship: BFO:0000050 UBERON:0001287
[Term]
id: CL:1000839
name: kidney proximal straight tubule epithelial cell
is_a: CL:0002306 ! epithelial cell of proximal tubule
is_a: CL:1000615 ! kidney cortex tubule cell
is_a: CL:1000616 ! kidney outer medulla cell
intersection_of: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: BFO:0000050 UBERON:0001290
relationship: BFO:0000050 UBERON:0001290
[Term]
id: CL:1000849
name: kidney distal convoluted tubule epithelial cell
is_a: CL:0002305 ! epithelial cell of distal tubule
intersection_of: CL:0002305 ! epithelial cell of distal tubule
intersection_of: BFO:0000050 UBERON:0001292
relationship: BFO:0000050 UBERON:0001292
[Term]
id: CL:1000850
name: macula densa epithelial cell
is_a: CL:0002305 ! epithelial cell of distal tubule
is_a: CL:1000618 ! juxtaglomerular complex cell
intersection_of: CL:0002305 ! epithelial cell of distal tubule
intersection_of: BFO:0000050 UBERON:0002335
relationship: BFO:0000050 UBERON:0002335
[Term]
id: CL:1000909
name: kidney loop of Henle epithelial cell
is_a: CL:1000494 ! nephron tubule epithelial cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: BFO:0000050 UBERON:0001288
relationship: BFO:0000050 UBERON:0001288
[Term]
id: CL:1000979
name: ureter smooth muscle cell
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:1000601 ! ureteral cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0006855
relationship: BFO:0000050 UBERON:0006855
[Term]
id: CL:1001021
name: kidney loop of Henle descending limb epithelial cell
is_a: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: BFO:0000050 UBERON:0001289
relationship: BFO:0000050 UBERON:0001289
[Term]
id: CL:1001111
name: kidney loop of Henle thin descending limb epithelial cell
def: "An epithelial cell that is part of some loop of Henle thin descending limb." []
is_a: CL:0002518 ! kidney epithelial cell
is_a: CL:1000616 ! kidney outer medulla cell
is_a: CL:1001021 ! kidney loop of Henle descending limb epithelial cell
intersection_of: CL:1001021 ! kidney loop of Henle descending limb epithelial cell
intersection_of: BFO:0000050 UBERON:0005096
relationship: BFO:0000050 UBERON:0005096
[Term]
id: CL:1001225
name: kidney collecting duct cell
def: "A cell that is part of a collecting duct of renal tubule." []
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: BFO:0000050 UBERON:0001232
[Term]
id: CL:1001318
name: renal interstitial pericyte
def: "A pericyte cell located in the kidney interstitium." []
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: BFO:0000050 UBERON:0005215
[Term]
id: CL:1001319
name: bladder cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001255
relationship: BFO:0000050 UBERON:0001255
[Term]
id: CL:1001320
name: urethra cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000057
relationship: BFO:0000050 UBERON:0000057
[Term]
id: CL:1001433
name: epithelial cell of exocrine pancreas
def: "An epithelial cell of the exocrine pancreas." []
synonym: "exocrine pancreas cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000017
[Term]
id: CL:1001434
name: olfactory bulb interneuron
def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" []
is_a: CL:0000099 ! interneuron
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002264
relationship: BFO:0000050 UBERON:0002264
[Term]
id: CL:1001451
name: sensory neuron of dorsal root ganglion
def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." []
synonym: "proprioceptive neuron" EXACT []
is_a: CL:0000101 ! sensory neuron
is_a: CL:4023168 ! somatosensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: RO:0002100 UBERON:0000044
relationship: BFO:0000050 UBERON:0000044
[Term]
id: CL:1001474
name: medium spiny neuron
def: "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus." []
synonym: "gamma-aminobutyric acid (GABA)ergic spiny projection neuron" EXACT []
synonym: "gamma-aminobutyric acid ergic spiny projection neuron" EXACT []
synonym: "medium-sized densely spiny neuron" RELATED []
synonym: "striatal medium spiny neuron" EXACT []
is_a: CL:0000617 ! GABAergic neuron
relationship: RO:0002100 UBERON:0000369
relationship: RO:0002215 GO:0061534
[Term]
id: CL:1001503
name: olfactory bulb tufted cell
def: "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." []
is_a: CL:0000540 ! neuron
relationship: BFO:0000050 UBERON:0005376
[Term]
id: CL:1001509
name: glycinergic neuron
def: "The neurons that utilize glycine as a neurotransmitter." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061537
[Term]
id: CL:1001567
name: lung endothelial cell
synonym: "endothelial cell of lung" RELATED []
synonym: "pulmonary vessel endothelial cell" RELATED []
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: BFO:0000050 UBERON:0002048
relationship: BFO:0000050 UBERON:0000102
[Term]
id: CL:1001568
name: pulmonary artery endothelial cell
synonym: "PAEC cell" RELATED []
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: BFO:0000050 UBERON:0002012
relationship: BFO:0000050 UBERON:0005317
[Term]
id: CL:1001569
name: hippocampal interneuron
def: "An interneuron with a soma found in the hippocampus." []
is_a: CL:0000099 ! interneuron
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002421
[Term]
id: CL:1001571
name: hippocampal pyramidal neuron
def: "A pyramidal neuron with a soma found in the hippocampus." []
synonym: "hippocampus (CA) pyramidal cell" NARROW []
synonym: "hippocampus (CA) pyramidal neuron" NARROW []
is_a: CL:0000598 ! pyramidal neuron
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0002421
relationship: BFO:0000050 UBERON:0002313
[Term]
id: CL:1001572
name: colon endothelial cell
def: "A vascular endothelial cell found in colon blood vessels." []
synonym: "colon endothelial cells" RELATED []
synonym: "colonic endothelial cell" RELATED []
is_a: CL:0000115 ! endothelial cell
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001155
relationship: BFO:0000050 UBERON:0013695
[Term]
id: CL:1001575
name: uterine cervix squamous cell
def: "Squamous cell of uterine cervix epithelium." []
synonym: "cervix squamous cell" RELATED []
synonym: "cervix squamous epithelial cell" RELATED []
synonym: "cervix, uterine squamous epithelial cells" RELATED []
synonym: "uterine cervix squamous epithelial cell" RELATED []
synonym: "uterine cervix squamous epithelial cells" RELATED []
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002535 ! epithelial cell of cervix
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: BFO:0000050 UBERON:0000002
relationship: BFO:0000050 UBERON:0004801
[Term]
id: CL:1001578
name: vagina squamous cell
def: "Squamous cell of vaginal epithelium." []
synonym: "vagina squamous epithelial cell" RELATED []
synonym: "vagina squamous epithelial cells" RELATED []
synonym: "vaginal squamous cell" RELATED []
synonym: "vaginal squamous epithelial cell" RELATED []
is_a: CL:0000076 ! squamous epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: BFO:0000050 UBERON:0000996
relationship: BFO:0000050 UBERON:0001344
[Term]
id: CL:1001579
name: cerebral cortex glial cell
def: "Glial cell of cerebral cortex." []
synonym: "brain cortex glial cell" RELATED []
synonym: "cerebral cortex glial cells" RELATED []
synonym: "cerebrum cortex glial cell" RELATED []
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0000956
[Term]
id: CL:1001580
name: hippocampal glial cell
def: "A glial cell that is part of the hippocampus." []
synonym: "hippocampus glial cell" EXACT []
synonym: "hippocampus neuroglial cell" EXACT []
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0002421
[Term]
id: CL:1001581
name: lateral ventricle glial cell
def: "Glial cell of lateral ventricle." []
synonym: "lateral ventricle glial cells" RELATED []
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0002285
[Term]
id: CL:1001582
name: lateral ventricle neuron
def: "Neuron of lateral ventricle." []
synonym: "lateral ventricle neural cell" RELATED []
synonym: "lateral ventricle neuronal cell" RELATED []
synonym: "lateral ventricle neuronal cells" RELATED []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002285
[Term]
id: CL:1001586
name: mammary gland glandular cell
def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." []
synonym: "breast glandular cell" RELATED []
synonym: "breast glandular cells" RELATED []
synonym: "mammary glandular cell" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002327 ! mammary gland epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001911
relationship: BFO:0000050 UBERON:0003244
[Term]
id: CL:1001587
name: uterine cervix glandular cell
def: "Glandular cell of uterine cervix epithelium." []
synonym: "cervix glandular cell" RELATED []
synonym: "cervix, uterine glandular cell" RELATED []
synonym: "cervix, uterine glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002535 ! epithelial cell of cervix
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0000002
relationship: BFO:0000050 UBERON:0004801
[Term]
id: CL:1001588
name: colon glandular cell
def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." []
synonym: "colon glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001155
relationship: BFO:0000050 UBERON:0000397
[Term]
id: CL:1001590
name: epididymis glandular cell
def: "Glandular cell of epididymal epithelium." []
synonym: "epididymal glandular cell" RELATED []
synonym: "epididymis glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001301
relationship: BFO:0000050 UBERON:0004544
[Term]
id: CL:1001591
name: oviduct glandular cell
def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." []
synonym: "fallopian tube glandular cell" RELATED []
synonym: "fallopian tube glandular cells" RELATED []
synonym: "uterine tube glandular cell" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0000993
relationship: BFO:0000050 UBERON:0004804
[Term]
id: CL:1001592
name: gallbladder glandular cell
def: "Glandular cell of gallbladder epithelium." []
synonym: "gall bladder glandular cell" EXACT []
synonym: "gall bladder glandular cells" RELATED []
synonym: "gallbladder glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:1000415 ! epithelial cell of gallbladder
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0002110
relationship: BFO:0000050 UBERON:0002029
[Term]
id: CL:1001593
name: parathyroid glandular cell
def: "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells." []
synonym: "parathyroid gland glandular cell" RELATED []
synonym: "parathyroid gland glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001132
relationship: BFO:0000050 UBERON:0011197
[Term]
id: CL:1001596
name: salivary gland glandular cell
def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." []
synonym: "salivary gland glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001044
relationship: BFO:0000050 UBERON:0004809
[Term]
id: CL:1001597
name: seminal vesicle glandular cell
def: "Glandular cell of seminal vesicle epithelium." []
synonym: "seminal vesicle glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0000998
relationship: BFO:0000050 UBERON:0004805
[Term]
id: CL:1001598
name: small intestine glandular cell
def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." []
synonym: "small bowel glandular cell" RELATED []
synonym: "small intestinal glandular cell" RELATED []
synonym: "small intestine glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0002108
relationship: BFO:0000050 UBERON:0001902
[Term]
id: CL:1001599
name: pancreas exocrine glandular cell
def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." []
synonym: "exocrine pancreas glandular cell" RELATED []
synonym: "pancreas exocrine glandular cells" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0000017
relationship: BFO:0000050 UBERON:0013697
[Term]
id: CL:1001601
name: adrenal gland glandular cell
def: "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." []
synonym: "adrenal gland glandular cells" RELATED []
synonym: "adrenal glandular cell" RELATED []
synonym: "suprarenal gland glandular cell" RELATED []
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001235
[Term]
id: CL:1001602
name: cerebral cortex endothelial cell
def: "Endothelial cells forming the walls of the capillaries within the cerebral cortex." []
synonym: "cerebral cortex endothelial cells" RELATED []
synonym: "endothelial cells of cerebral cortex" RELATED []
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000956
relationship: BFO:0000050 UBERON:0013694
[Term]
id: CL:1001603
name: lung macrophage
def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." []
synonym: "lung macrophages" RELATED []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: BFO:0000050 UBERON:0002048
[Term]
id: CL:1001609
name: muscle fibroblast
def: "Fibroblast from muscle organ." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001630
[Term]
id: CL:1001610
name: bone marrow hematopoietic cell
def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." []
synonym: "bone marrow hematopoietic cells" RELATED []
synonym: "bone marrow poietic cells" RELATED []
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: BFO:0000050 UBERON:0002371
relationship: BFO:0000050 UBERON:0012429
[Term]
id: CL:1001611
name: cerebellar neuron
def: "Neuron of the cerebellum." []
synonym: "cerebellum neuron" RELATED []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002037
[Term]
id: CL:2000000
name: epidermal melanocyte
def: "Any melanocyte that is part of a epidermis." []
is_a: CL:0000148 ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: BFO:0000050 UBERON:0001003
[Term]
id: CL:2000004
name: pituitary gland cell
def: "Any cell that is part of a pituitary gland." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000007
[Term]
id: CL:2000005
name: brain macroglial cell
def: "Any macroglial cell that is part of a brain." []
is_a: CL:0000126 ! macroglial cell
intersection_of: CL:0000126 ! macroglial cell
intersection_of: BFO:0000050 UBERON:0000955
[Term]
id: CL:2000018
name: endothelial cell of coronary artery
def: "Any endothelial cell of artery that is part of a coronary artery." []
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:1000413 ! endothelial cell of artery
intersection_of: BFO:0000050 UBERON:0001621
[Term]
id: CL:2000019
name: compound eye photoreceptor cell
def: "Any photoreceptor cell that is part of a compound eye." []
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: BFO:0000050 UBERON:0000018
[Term]
id: CL:2000020
name: inner cell mass cell
def: "Any native cell that is part of a inner cell mass." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000087
[Term]
id: CL:2000021
name: sebaceous gland cell
def: "Any native cell that is part of a sebaceous gland." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001821
[Term]
id: CL:2000022
name: cardiac septum cell
def: "Any native cell that is part of a cardiac septum." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002099
[Term]
id: CL:2000025
name: spinal cord oligodendrocyte
def: "Any oligodendrocyte that is part of a spinal cord." []
is_a: CL:0000128 ! oligodendrocyte
intersection_of: CL:0000128 ! oligodendrocyte
intersection_of: BFO:0000050 UBERON:0002240
[Term]
id: CL:2000028
name: cerebellum glutamatergic neuron
def: "Any glutamatergic neuron that is part of a cerebellum." []
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000679 ! glutamatergic neuron
intersection_of: RO:0002100 UBERON:0002037
[Term]
id: CL:2000029
name: central nervous system neuron
def: "Any neuron that is part of a central nervous system." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001017
[Term]
id: CL:2000030
name: hypothalamus cell
def: "Any native cell that is part of a hypothalamus." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001898
[Term]
id: CL:2000031
name: lateral line ganglion neuron
def: "Any neuron that is part of a lateral line ganglion." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:2000120
[Term]
id: CL:2000032
name: peripheral nervous system neuron
def: "A neuron that is part of a peripheral nervous system." []
synonym: "peripheral neuron" EXACT []
synonym: "PNS neuron" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000010
[Term]
id: CL:2000033
name: limb basal cell of epidermis
def: "Any basal cell of epidermis that is part of a limb." []
is_a: CL:0002187 ! basal cell of epidermis
intersection_of: CL:0002187 ! basal cell of epidermis
intersection_of: BFO:0000050 UBERON:0002101
[Term]
id: CL:2000034
name: anterior lateral line neuromast hair cell
def: "Any neuromast hair cell that is part of a anterior lateral line." []
is_a: CL:0000856 ! neuromast hair cell
intersection_of: CL:0000856 ! neuromast hair cell
intersection_of: BFO:0000050 UBERON:2001470
[Term]
id: CL:2000035
name: anterior lateral line neuromast mantle cell
def: "Any neuromast mantle cell that is part of an anterior lateral line." []
is_a: CL:0000851 ! neuromast mantle cell
intersection_of: CL:0000851 ! neuromast mantle cell
intersection_of: BFO:0000050 UBERON:2001470
[Term]
id: CL:2000036
name: anterior lateral line neuromast supporting cell
def: "Any neuromast support cell that is part of a anterior lateral line." []
synonym: "anterior lateral line neuromast support cell" EXACT []
is_a: CL:0000852 ! neuromast supporting cell
intersection_of: CL:0000852 ! neuromast supporting cell
intersection_of: BFO:0000050 UBERON:2001470
[Term]
id: CL:2000037
name: posterior lateral line neuromast hair cell
def: "Any neuromast hair cell that is part of a posterior lateral line." []
is_a: CL:0000856 ! neuromast hair cell
intersection_of: CL:0000856 ! neuromast hair cell
intersection_of: BFO:0000050 UBERON:0006334
[Term]
id: CL:2000038
name: posterior lateral line neuromast mantle cell
def: "Any neuromast mantle cell that is part of a posterior lateral line." []
is_a: CL:0000851 ! neuromast mantle cell
intersection_of: CL:0000851 ! neuromast mantle cell
intersection_of: BFO:0000050 UBERON:0006334
[Term]
id: CL:2000039
name: posterior lateral line neuromast supporting cell
def: "Any neuromast support cell that is part of a posterior lateral line." []
synonym: "posterior lateral line neuromast support cell" EXACT []
is_a: CL:0000852 ! neuromast supporting cell
intersection_of: CL:0000852 ! neuromast supporting cell
intersection_of: BFO:0000050 UBERON:0006334
[Term]
id: CL:2000042
name: embryonic fibroblast
def: "Any fibroblast that is part of a embryo." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0000922
[Term]
id: CL:2000043
name: brain pericyte
def: "Any pericyte cell that is part of a brain." []
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: BFO:0000050 UBERON:0000955
[Term]
id: CL:2000046
name: ventricular cardiac muscle cell
def: "Any cardiac muscle cell that is part of a cardiac ventricle." []
is_a: CL:0000746 ! cardiac muscle cell
intersection_of: CL:0000746 ! cardiac muscle cell
intersection_of: BFO:0000050 UBERON:0002082
[Term]
id: CL:2000047
name: brainstem motor neuron
def: "Any motor neuron that is part of a brainstem." []
is_a: CL:0000100 ! motor neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002100 UBERON:0002298
[Term]
id: CL:2000049
name: primary motor cortex pyramidal cell
def: "Any pyramidal cell that is part of a primary motor cortex." []
is_a: CL:0000598 ! pyramidal neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0001384
[Term]
id: CL:2000051
name: splenic fibroblast
def: "Any fibroblast that is part of a spleen." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002106
[Term]
id: CL:2000052
name: umbilical artery endothelial cell
def: "Any endothelial cell of artery that is part of a umbilical cord." []
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:1000413 ! endothelial cell of artery
intersection_of: BFO:0000050 UBERON:0002331
[Term]
id: CL:2000053
name: splenic endothelial cell
def: "Any endothelial cell that is part of a spleen." []
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0002106
[Term]
id: CL:2000055
name: liver dendritic cell
def: "Any dendritic cell that is part of a liver." []
synonym: "hepatic dendritic cell" EXACT []
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: BFO:0000050 UBERON:0002107
[Term]
id: CL:2000056
name: Meynert cell
def: "Any pyramidal cell that is part of a regional part of cerebral cortex." []
is_a: CL:2000049 ! primary motor cortex pyramidal cell
relationship: RO:0002100 UBERON:0001384
[Term]
id: CL:2000061
name: placental amniotic mesenchymal stromal cell
def: "Any mesenchymal stem cell that is part of a placenta." []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: BFO:0000050 UBERON:0001987
[Term]
id: CL:2000063
name: ovarian fibroblast
def: "Any fibroblast that is part of a female gonad." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0000992
[Term]
id: CL:2000064
name: ovarian surface epithelial cell
def: "Any epithelial cell that is part of a female gonad." []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000992
[Term]
id: CL:2000066
name: cardiac ventricle fibroblast
def: "Any fibroblast that is part of a cardiac ventricle." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002082
[Term]
id: CL:2000067
name: cardiac atrium fibroblast
def: "Any fibroblast that is part of a cardiac atrium." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002081
[Term]
id: CL:2000068
name: pericardium fibroblast
def: "Any fibroblast that is part of a pericardium." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002407
[Term]
id: CL:2000069
name: gallbladder fibroblast
def: "Any fibroblast that is part of a gallbladder." []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002110
[Term]
id: CL:2000073
name: migratory cardiac neural crest cell
def: "Any migratory neural crest cell that is part of a cardiac neural crest." []
synonym: "cardiac neural crest cell" EXACT []
is_a: CL:0000333 ! migratory neural crest cell
intersection_of: CL:0000333 ! migratory neural crest cell
intersection_of: BFO:0000050 UBERON:0000095
[Term]
id: CL:2000074
name: splenocyte
def: "Any leukocyte that is part of a spleen." []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: BFO:0000050 UBERON:0002106
[Term]
id: CL:2000075
name: anterior visceral endoderm cell
def: "Any endodermal cell that is part of a anterior visceral endoderm." []
is_a: CL:0000223 ! endodermal cell
intersection_of: CL:0000223 ! endodermal cell
intersection_of: BFO:0000050 UBERON:0004044
[Term]
id: CL:2000078
name: placental pericyte
def: "Any pericyte cell that is part of a placenta." []
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: BFO:0000050 UBERON:0001987
[Term]
id: CL:2000085
name: mononuclear cell of umbilical cord
def: "Any mononuclear cell that is part of a umbilical cord." []
is_a: CL:0000842 ! mononuclear cell
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: BFO:0000050 UBERON:0002331
[Term]
id: CL:2000089
name: dentate gyrus granule cell
def: "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." []
synonym: "dentate gyrus of hippocampal formation granule cell" EXACT []
is_a: CL:0001033 ! hippocampal granule cell
intersection_of: CL:0001033 ! hippocampal granule cell
intersection_of: RO:0002100 UBERON:0005381
[Term]
id: CL:2000090
name: dentate gyrus of hippocampal formation stellate cell
def: "Any stellate cell that is part of a dentate gyrus of hippocampal formation." []
is_a: CL:0000122 ! stellate neuron
is_a: CL:4023062 ! dentate gyrus neuron
intersection_of: CL:0000122 ! stellate neuron
intersection_of: RO:0002100 UBERON:0001885
[Term]
id: CL:2000092
name: hair follicular keratinocyte
def: "Any keratinocyte that is part of a hair follicle." []
is_a: CL:0000312 ! keratinocyte
is_a: CL:0002559 ! hair follicle cell
intersection_of: CL:0000312 ! keratinocyte
intersection_of: BFO:0000050 UBERON:0002073
[Term]
id: CL:2000093
name: bronchus fibroblast of lung
def: "Any fibroblast of lung that is part of a bronchus." []
is_a: CL:0002553 ! fibroblast of lung
intersection_of: CL:0002553 ! fibroblast of lung
intersection_of: BFO:0000050 UBERON:0002185
[Term]
id: CL:2000097
name: midbrain dopaminergic neuron
def: "Any dopaminergic neuron that is part of a midbrain." []
is_a: CL:0000700 ! dopaminergic neuron
intersection_of: CL:0000700 ! dopaminergic neuron
intersection_of: RO:0002100 UBERON:0001891
[Term]
id: CL:3000002
name: sympathetic noradrenergic neuron
def: "Sympathetic noradrenergic neuron." []
is_a: CL:0008025 ! noradrenergic neuron
is_a: CL:0011103 ! sympathetic neuron
intersection_of: CL:0011103 ! sympathetic neuron
intersection_of: RO:0002215 GO:0061533
[Term]
id: CL:3000003
name: sympathetic cholinergic neuron
def: "Sympathetic cholinergic neuron." []
is_a: CL:0000108 ! cholinergic neuron
is_a: CL:0011103 ! sympathetic neuron
intersection_of: CL:0011103 ! sympathetic neuron
intersection_of: RO:0002215 GO:0014055
[Term]
id: CL:3000004
name: peripheral sensory neuron
def: "Peripheral sensory neuron." []
is_a: CL:0000101 ! sensory neuron
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002215 GO:0050906
[Term]
id: CL:4023039
name: amygdala excitatory neuron
is_a: CL:0000679 ! glutamatergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001876
intersection_of: RO:0002215 GO:0061535
[Term]
id: CL:4023057
name: cerebellar inhibitory GABAergic interneuron
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: RO:0002100 UBERON:0002129
[Term]
id: CL:4023062
name: dentate gyrus neuron
def: "A neuron with its soma located in the dentate gyrus of the hippocampus." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001885
[Term]
id: CL:4023074
name: mammillary body neuron
def: "A neuron that has its soma located in the mammillary body." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002206
[Term]
id: CL:4023079
name: midbrain-derived inhibitory neuron
def: "A GABAergic inhibitory neuron that is derived from the midbrain." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002202 UBERON:0001891
[Term]
id: CL:4023110
name: amygdala pyramidal neuron
def: "A pyramidal neuron with soma located in the amygdala." []
is_a: CL:0000598 ! pyramidal neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0001876
[Term]
id: CL:4023111
name: cerebral cortex pyramidal neuron
def: "A pyramidal neuron with soma located in the cerebral cortex." []
is_a: CL:0000598 ! pyramidal neuron
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0000956
[Term]
id: CL:4023120
name: cochlea auditory hair cell
def: "An auditory hair cell found in the cochlea." []
synonym: "cochlear hair cell" EXACT []
is_a: CL:0000202 ! auditory hair cell
intersection_of: CL:0000202 ! auditory hair cell
intersection_of: BFO:0000050 UBERON:0002227
[Term]
id: CL:4023154
name: myelinating glial cell
def: "A glial cell that myelinates axonal processes." []
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000051 GO:0043209
[Term]
id: CL:4023168
name: somatosensory neuron
def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: BFO:0000050 UBERON:0003942
[Term]
id: CL:4029001
name: gamete-nursing cell
def: "A cell that supports the development of a gamete by providing it cytoplasmic material (including entire organelles) by direct cross-membrane channels (del Pino, 2021)." []
is_a: CL:0000000 ! cell
[Term]
id: CL:4029002
name: germline-derived nurse cell
def: "A gamete-nursing cell that derives from a germline cell (del Pino, 2021)." []
is_a: CL:0000039 ! germ line cell
is_a: CL:4029001 ! gamete-nursing cell
[Term]
id: CL:4030001
name: stromal cell of thymus
def: "A stromal cell that is part of the thymus." []
synonym: "thymic stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0002370
[Term]
id: CL:4030008
name: pronephric podocyte
def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros." []
synonym: "pronephric glomerular visceral epithelial cell" EXACT []
is_a: CL:0000653 ! podocyte
intersection_of: CL:0000653 ! podocyte
intersection_of: BFO:0000050 UBERON:0002120
[Term]
id: CL:4030012
name: kidney loop of Henle short descending thin limb epithelial cell
def: "Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2." []
synonym: "epithelial cell of the descending thin limb of the short loop of Henle" EXACT []
is_a: CL:1001111 ! kidney loop of Henle thin descending limb epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005099
[Term]
id: CL:4030016
name: epithelial cell of early distal convoluted tubule
def: "An epithelial cell located in the early distal convoluted tubule." []
synonym: "DCT1 cell" BROAD []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005101
[Term]
id: CL:4030017
name: epithelial cell of late distal convoluted tubule
def: "An epithelial cell located in the late distal convoluted tubule." []
synonym: "DCT2 cell" BROAD []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005102
[Term]
id: CL:4030027
name: GABAergic amacrine cell
def: "An amacrine cell that uses GABA as a neurotransmitter." []
synonym: "amacrine cell, GABAergic" EXACT []
is_a: CL:0000561 ! amacrine cell
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0000561 ! amacrine cell
intersection_of: RO:0002215 GO:0061534
[Term]
id: CL:4030028
name: glycinergic amacrine cell
def: "An amacrine cell that uses glycine as a neurotransmitter." []
synonym: "amacrine cell, glycinergic" EXACT []
is_a: CL:0000561 ! amacrine cell
is_a: CL:1001509 ! glycinergic neuron
intersection_of: CL:0000561 ! amacrine cell
intersection_of: RO:0002215 GO:0061537
[Term]
id: CL:4030033
name: valve endothelial cell
def: "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." []
synonym: "valvular endothelial cell" EXACT []
synonym: "VEC" EXACT []
is_a: CL:0000115 ! endothelial cell
is_a: CL:1000147 ! cardiac valve cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000946
[Term]
id: CL:4030034
name: respiratory ciliated cell
def: "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." []
synonym: "ciliated cell of the respiratory tract" EXACT []
is_a: CL:0000064 ! ciliated cell
intersection_of: CL:0000064 ! ciliated cell
intersection_of: BFO:0000050 UBERON:0004802
relationship: BFO:0000050 UBERON:0001004
[Term]
id: CL:4030035
name: dental pulp stem cell
def: "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." []
synonym: "DPSC" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:0002148 ! dental pulp cell
intersection_of: CL:0000034 ! stem cell
intersection_of: BFO:0000050 UBERON:0001754
[Term]
id: CL:4030058
name: TCR-positive macrophage
def: "A macrophage that expresses the T cell receptor complex at the cell surface." []
synonym: "T cell receptor positive macrophage" EXACT []
synonym: "TCR+ macrophage" EXACT []
synonym: "TCR.macs" RELATED []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: RO:0002104 GO:0042101
[Term]
id: CL:4030066
name: ureteric bud cell
def: "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." []
synonym: "UB cell" RELATED []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000084
relationship: RO:0000056 GO:2001013
[Term]
id: CL:4033008
name: vein endothelial cell of respiratory system
def: "A(n) vein endothelial cell that is part of a(n) respiratory system." []
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0002543 ! vein endothelial cell
intersection_of: BFO:0000050 UBERON:0001004
[Term]
id: CL:4033009
name: goblet cell of epithelium of lobar bronchus
def: "A(n) goblet cell that is part of a(n) epithelium of lobar bronchus." []
is_a: CL:0000160 ! goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: BFO:0000050 UBERON:0002339
[Term]
id: CL:4033010
name: neuroendocrine cell of epithelium of lobar bronchus
def: "A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus." []
is_a: CL:0000165 ! neuroendocrine cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: BFO:0000050 UBERON:0002339
[Term]
id: CL:4033015
name: retinal astrocyte
def: "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." []
synonym: "retinal astroglia" RELATED []
is_a: CL:0000127 ! astrocyte
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0000966
[Term]
id: CL:4033017
name: bronchiolar smooth muscle cell
def: "A smooth muscle cell that is part of a bronchiole." []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002186
relationship: BFO:0000050 UBERON:0004515
[Term]
id: CL:4033018
name: lung megakaryocyte
def: "A megakaryocyte that is resident in the lung connective tissue." []
synonym: "lung MKs" RELATED []
synonym: "lung resident megakaryocyte" EXACT []
synonym: "lung-resident megakaryocyte" EXACT []
synonym: "MKL" RELATED []
is_a: CL:0000556 ! megakaryocyte
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: BFO:0000050 UBERON:0000114
[Term]
id: CL:4033020
name: mucus secreting cell of trachea gland
def: "A mucus secreting cell that is part of a submucosal gland of the trachea." []
synonym: "tracheal submucosal gland mucous cell" EXACT []
is_a: CL:0000319 ! mucus secreting cell
intersection_of: CL:0000319 ! mucus secreting cell
intersection_of: BFO:0000050 UBERON:0005203
[Term]
id: CL:4033050
name: catecholaminergic neuron
def: "A neuron that releases catecholamine as a neurotransmitter." []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0160043
[Term]
id: CL:4033054
name: perivascular cell
def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." []
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002220 UBERON:0002049
[Term]
id: CL:4033057
name: luminal adaptive secretory precursor cell of mammary gland
def: "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8." []
synonym: "alveolar cell" BROAD []
synonym: "alveolar progenitor" BROAD []
synonym: "AP" RELATED []
synonym: "AV" RELATED []
synonym: "ER-negative luminal alveolar progenitor" EXACT []
synonym: "LASP" RELATED []
synonym: "LP" RELATED []
synonym: "luminal progenitor" BROAD []
synonym: "luminal progenitor cell" BROAD []
synonym: "luminal secretory cell" BROAD []
synonym: "LumSec" RELATED []
is_a: CL:0002326 ! luminal epithelial cell of mammary gland
is_a: CL:0011115 ! precursor cell
[Term]
id: CL:4033064
name: uterine resident macrophage
def: "A tissue-resident macrophage that is part of the uterus." []
synonym: "uterine macrophage" BROAD []
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: BFO:0000050 UBERON:0000995
[Term]
id: CL:4040002
name: enteroglial cell
def: "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." []
synonym: "enteric glia" RELATED []
synonym: "enteric glial cell" EXACT []
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0002005
relationship: RO:0002292 PR:000007939
[Term]
id: CL:4040003
name: fetal pre-type II pneumocyte
def: "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." []
synonym: "fetal alveolar pre-type II epithelial cell" EXACT []
synonym: "fetal pre-type 2 pneumocyte" EXACT []
synonym: "fetal pre-type II alveolar epithelial cell" EXACT []
is_a: CL:0000322 ! pneumocyte
[Typedef]
id: BFO:0000050
xref: BFO:0000050
[Typedef]
id: BFO:0000051
xref: BFO:0000051
[Typedef]
id: RO:0000053
xref: RO:0000053
[Typedef]
id: RO:0000056
xref: RO:0000056
[Typedef]
id: RO:0001025
xref: RO:0001025
[Typedef]
id: RO:0002100
xref: RO:0002100
[Typedef]
id: RO:0002102
xref: RO:0002102
[Typedef]
id: RO:0002103
xref: RO:0002103
[Typedef]
id: RO:0002104
xref: RO:0002104
[Typedef]
id: RO:0002120
xref: RO:0002120
[Typedef]
id: RO:0002160
xref: RO:0002160
[Typedef]
id: RO:0002162
xref: RO:0002162
[Typedef]
id: RO:0002202
xref: RO:0002202
[Typedef]
id: RO:0002203
xref: RO:0002203
[Typedef]
id: RO:0002207
xref: RO:0002207
[Typedef]
id: RO:0002215
xref: RO:0002215
[Typedef]
id: RO:0002216
xref: RO:0002216
[Typedef]
id: RO:0002220
xref: RO:0002220
[Typedef]
id: RO:0002292
xref: RO:0002292
[Typedef]
id: RO:0002339
xref: RO:0002339
[Typedef]
id: RO:0002353
xref: RO:0002353
[Typedef]
id: RO:0003000
xref: RO:0003000
[Typedef]
id: RO:0015015
xref: RO:0015015
[Typedef]
id: RO:0015016
xref: RO:0015016
[Typedef]
id: has_not_completed
name: has_not_completed
xref: CL:4030044
[Typedef]
id: lacks_part
name: lacks_part
xref: CL:4030045
[Typedef]
id: lacks_plasma_membrane_part
name: lacks_plasma_membrane_part
xref: CL:4030046